Michael Kilberg, Ph.D.
Research: Nutrient control of transcription; drug resistance in leukemia
Professor Michael S. Kilberg earned his Ph.D. in biochemistry and molecular biology. He did post-doctoral studies at the University of Michigan, before joining the faculty at UF. He has written numerous reviews, organized several symposia, and written multiple chapters for both the Annual Review of Nutrition and the Annual Review of Biochemistry. Dr. Kilberg has served three terms on the Editorial Board of the Journal of Biological Chemistry. Dr. Kilberg has received the University of Florida Doctoral Advisor/Mentoring Award, the College of Medicine Faculty Research Award, and a University of Florida Research Foundation Professorship.
We are investigating transcriptional and epigenetic regulation of several human genes in response to protein/amino acid stress, the Amino Acid Response (AAR), such as occurs during a protein-deficient diet and numerous disease states. Identification of amino acid responsive genomic elements (AARE) has led to a focus on the corresponding transcription factors to identify mechanisms for “regulation of the regulators.” Among these transcription factors are the bZIP proteins ATF4, ATF3,cJUN, cFOS, and C/EBPb. A principle goal of our work is to identify the novel amino acid-dependent signaling mechanisms for the induction of these and other transcription factors in tumors, a response that may allow them to grow despite poor nutrient supply.