Virus Journal Features Agbandje-McKenna Lab Article

Members of the Agbandje-McKenna lab group co-authored an article, Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy, which was published in the January 2018 issue of the Virus journal and featured on the journal cover.

The writing group includes Maria Ilyas, Mario Mietzsch, Viruses-CoverShweta Kailasan, Elina Väisänen, Mengxiao Luo, Paul Chipman, J. Kennon Smith, Justin Kurian, Duncan Sousa, Robert McKenna, Maria Söderlund-Venermo and Mavis Agbandje-McKenna.

The conclusions of this study report the first structures determined for human-infecting members of the Protoparvovirus genus, which until recently, contained only animal infecting members. Significantly, while the structure conserved the VP topology of other members of this genus, a deletion and conformational difference at one of the loops forming the 3-fold region results in capsid surface morphology that resembles the other human-infecting parvoviruses from other genera. This suggests a host-specific function for the separated arrangement of the protrusions surrounding the 3-fold region. These structures will aid future efforts at functional annotation.

The Department of Biochemistry and Molecular Biology congratulates the Agbandje-McKenna lab on this publication!

For more information on the Dr. Mavis Agbandje-McKenna’s lab, click here.