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Department of Biochemistry and Molecular Biology

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Presentation History
Biochemistry and Molecular Biology Journal Club

Spring 2021 Presentations

BMB Journal Club Spring 2021

Spring 2019 Presentations

Spring 2018 Presentations

Fall 2017 Presentations

Spring 2017 Presentations

Fall 2016 Presentations

Spring 2013 Presentations

Topic: TBA

Fall 2012 Presentations

Topic: Gene Therapy

  • 11/27/12 – Melissa Pinard presented Wu, C.et al. (2012) Intra-amnionic transient transfection of the periderm with a viral vector encoding TGFβ3 prevents cleft palate in Tgfβ3-/- mouse embryos. Molecular Therapy 20, Oct. 23 Advanced online publication.
  • 11/13/12 – Lin-Ya Huang presented Wather, W. et al. (2012) Novel Clostridium perfringens enterotoxin suicide gene therapy for selective treatment of claudin-3- and -4-overexpressing tumors. Gene Therapy 19, 494-503.
  • 11/6/12 – Elizabeth Butterworth presented Ildefonso, C.J. et al. (2012) The liberation of CD44 intracellular domain modulates adenoviral vector transgene expression. J. Biol. Chem 287, 32697-32707.
  • 10/30/12 – Stephanie Morton presented Hicks, M.J. et al. (2012) AAV-directed persistent expression of a gene encoding anti-nicotine antibody for smoking cessation. Science Translational Medicine 4 1 – 12.
  • 10/24/12 – Pamela Chamales presented Akil, O. et al. (2012) Restoration of hearing in the VGLUT3 knockout mouse using virally mediated gene therapy. Neuron 75, 283-293.
  • 10/9/12 – Justin Runac presented Voigt et al. (2012) Retargeting Sleeping Beauty transposon insertions by engineered zing finger DNA-binding domains. Molecular Therapy 20, 1852-1862.
  • 10/2/12 – Shweta Kailasan presented Touchard, E.et al. (2012) Suprachoroidal electrotransfer: A nonviral gene delivery method to transfect the choroid and the retina without detaching the retina. Molecular Therapy 20, 1559-1570.
  • 9/25/12 – Mayank Talwar presented Li, H.et al. (2011) In vivo genome editing restores haemostasis in a mouse model of haemophilia. Nature 475, 217-221.
  • 9/18/12 – Jacob Richards presented Agudo, J.et al. (2012) A TLR and Non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade. Molecular Therapy, Aug. 7, advanced online publication.
  • 9/11/12 – Fran Tondnevis presented Spencer, B.et al. (2009) Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD. Molecular Therapy, advanced online publication .
  • 9/4/12 – Chris Boone presented Mancuso, K.et al. (2009) Gene therapy for red-green colour blindness in adult primates. Nature 461, 784-787.

Spring 2012 Presentations

Topic: Intrinsically Disordered Proteins, and Misfolded Proteins and Disease

  • 4/10/12 – Stephanie Morton presented Majumdar, A.et al. (2012) Critical role of amyloid-like oligomers of Drosphophila Orb2 in the persistence of memory. Cell 148, 515-529.
  • 3/27/12 – Mayank Talwar presented Koch, P.et al. (2011) Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature 480, 543-546.
  • 3/20/12 – Chris Boone presented Krueger, S.et al. (2011) Atomistic ensemble modeling and small-angle neutron scattering of intrinsically disordered protein complexes: Applied to minichromosome maintenance protein. Biophys. J. 101, 2999-3007.
  • 3/13/12 – Pamela Chamales presented Reichmann, D.et al. (2012) Order out of disorder: Working cycleo of an intrinsically unfolded chaperone. Cell 148, 947-957.
  • 2/14/12 – Jacob Richards presented Johannsson, B.B.et al. (2011) Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): A protein misfolding disease. J. Biol. Chem. 286, 34593-34605.
  • 2/7/12 – Natalia Torres presented Baldo, B.et al. (2012) A screen for enhancers of clearance identifies Huntingtin as a heat shock protein 90 (Hsp90) client protein. J. Biol. Chem. 287, 1406-1414.
  • 1/31/12 – Fran Tondnevis presented Stöhr, J.et al. (2011) Spontaneous generation of anchorless prions in transgenic mice. PNAS 108, 21223-21228.
  • 1/24/12 – Shweta Kailasan presented Kovac, A.et al. (2011) Misfolded truncated protein τ induces innate immune response via MAPK pathway. J. Immunology 187, 2732-2739.
  • 1/17/12 – Dayne West presented Halfmann, R.et al. (2011) Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Molecular Cell 43, 72-84.

Fall 2011 Presentations

Topic: Extremophiles

  • 11/8/11 – Joeva Barrow presented Grohmann, D.et al. (2011) The initiation factor TFE and the elongation factor Spt4/5 compete for the RNAP clamp during transcription initiation and elongation. Molecular Cell 43, 263-274.
  • 11/1/11 – Tal Salz presented Desai, S.S.et al. (2011) Characterization of the role of the RadS/RadR two-component system in the radiation resistance of Deinococcus radiodurans. Microbiology 157, 2974-2982.
  • 10/25/11 – Kyle Heim presented Slade, D.et al. (2009) Recombination and replication in DNA repair of heavily irradiated Deinococcus radiodurans. Cell 136, 1044-1055.
  • 10/11/11 – Bridget Lins presented Duplantis, B.N.et al. (2010) Essential genes from Artic bacteria used to construct stable, temperature-sensitive bacterial vaccines. PNAS 107, 13456-13460.
  • 10/4/11 – Yu-shan Tsen presented Koto, S.et al. (2010) Characterization of an ATP-regulated DNA-processing enzyme and thermotolerant phosphodiesterase in the radioresistant bacterium Deinococcus radiodurans. Bichemical J. 431, 149-157.
  • 9/27/11 – Gregory Stupp presented Chakrabortee, S. et al. (2010) Catalytic and chaperone-like functions in an intrinsically disorderd protein associated with desiccation tolerance. PNAS 107, 16084-16089.
  • 9/20/11 – Mayank Aggarwal presented Zambare, V.P. et al. (2011) Bioprocessing of agricultural residues to ethanol utilizing a celluolytic extremophile. Extremophiles 15, 611-618.
  • 9/13/11 – Harald Messer presented Scheele, U. et al. (2011) Chaperone role for proteins p618 and p892 in the extracellular tail development of Acidianus Two-tailed virus. J. Virol. 85, 4812-4821.
  • 9/6/11 – Chaevien Clendinen presented Henzler-Wildman, K.A. et al. (2007) A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature 450, 913-916.

Spring 2011 Presentations

Topic: Cancer

  • 4/19/11 – Yushan Tseng presented Parsa, H. et al. (2011) Uncovering the behaviors of individual cells within a multicellular microvascular community. PNAS 108, 5133-5138.
  • 4/12/11 – Harald Messer presented Nazarian, R. et al. (2010) Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature 468, 973-977.
  • 4/5/11 – Bridget Lins presented Duda, D.G. et al. (2010) Malignant cells facilitate lung metastasis by bringing their own soil. PNAS 107, 21677-21682.
  • 3/29/11 – Mayank Aggarwal presented Wang, Q. et al. (2011) Mutant proteins as cancer-specific biomarkers. PNAS 108, 2444-2449.
  • 3/22/11 – Joeva Barrow presented Kim, J. et al. (2010) A Myc network accounts for similiarities between embryonic stem and cancer cell transcription programs. Cell 143, 313-324.
  • 3/01/11 – Kyle Heim presented Bandyopadhyay, K. and Gjerset, R.A. (2011) Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothectin sensitivity in cancer cell lines. Biochemistry 50, 704-714.
  • 2/08/11 – Bhavita Patel presented Gilbert, L.A. and Hemann, M.T. (2010) DNA damage-mediated induction of a chemoresistant niche. Cell 143, 355-366.
  • 2/01/11 – Greg Stupp presented Suzuki, S. et al. (2010) Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. PNAS 107, 7461-7466.
  • 1/25/11 – Tal Salz presented Selivanova, G. et al. (2010) Rescue of p53 function by small-molecule RITA in cervical carcinoma by blocking E6-mediated degradation. Cancer Res. 70, 3372-3381.
  • 1/18/11 – Dayne West presented Takahashi, H. et al. (2010) Tobacco smoke promotes lung tumorigenesis by triggering IKKβ- and JNK1-dependent inflamation. Cancer Cell 17, 89-97.

Fall 2010 Presentations

Topic: DNA mismatch repair

  • 12/07/10 – Mollie Martin presented Xu, X. et al. (2010) TAp63 suppresses metastasis through coordinate regulation of dicer and miRNAs. Nature 467, 986-990.
  • 11/30/10 – Chaevien Clendinen presented Yew, J.Y. et al. (2009) A new male sex pheromone and novel cuticular cues for chemical communication in Drosophila. Current Biology 19, 1245-1254
  • 11/16/10 – Larry Tartaglia presented Shrimali, R.K. et al. (2010) Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Research 70, 6171-6180.
  • 11/09/10 – Sarah Barilovits presented Lee, B.-H. et al. (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467, 179-184.
  • 11/2/10 – Ryan Skehan presented Andersson Φrom, U. et al. (2010) Long noncoding RNAs with enhancer-like function in human cells. Cell 143, 46-58.
  • 10/19/10 – Lauren Drouin presented Spangler, J.B. et al. (2010) Combination antibody treatment down-regulates epidermal growth factor receptor by inhibitin endosomal recycling. PNAS 107, 13252-13257.
  • 10/14/10 – Dr. Paul Modrich, James B. Duke Professor of Biochemistry and Howard Hughes Medical Institute Investigatorat Duke University presented his research “Human DNA Mismatch Repair: What We’ve Learned About How it Works.”
  • 10/12/10 – Kavitha Gnanasambandan presented Carneiro, T. et al. (2010) Telomeres avoid end detection by severing the checkpoint signal transduction pathway. Nature 467, 228-232
  • 10/5/10 – Jaclyn Hayner presented Panigrahi, G.B. et al. (2010) Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSβ, but clusterd slip-outs are poorly repaired. PNAS 107, 12593-12598.
  • 9/28/10 – River Ybarra presented Pluciennik, A. et al. (2010) PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair. PNAS 107, 16066-13071.
  • 9/21/10 – Mukundh Balasubramanian presented Javaid, S. et al. (2009) Nucleosome Remodeling by hMSH2-hMSH6. Mol. Cell 36, 1086-1094.
  • 9/14/10 – Robert Ng presented Yang, J-L. et al. (2010) Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1. J. Biol. Chem. 285, 28191-28199.
  • 9/7/10 – Bala Venkatakrishnan presented Gorman, J. et al. (2010) Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice. Nature Struct. & Mol. Biol. 17, 932-938.

Spring 2010 Presentations

Topic: Structural Biology/Biological Nanomachines

  • 5/4/10 – Larry Tartaglia presented Ren, Y. et al. (2009) A structure-based mechanism for vesicle capture by the multisubunit tethering complex Dsl1. Cell 139, 1119-1129.
  • 4/27/10 – Suzanne Farver presented Kirkegaard, T. et al. (2010) HSP70 stabilizes lysosomes and reverts Niemann-Pick disease associated lysosomal pathology. Nature 463, 549-553
  • 4/13/10 – Lauren Drouin presented Di Pietro, S.M. et al. (2010) Regulation of clathrin adapter function in endocytosis: novel role for the SAM domain. EMBO Journal 29, 1033-1044.
  • 4/6/10 – Jaclyn Hayner presented Kocik, E. et al. (2009) Interactions between subunits in heterodimeric Ncd molecules. J. Biol. Chem. 284, 35735-35745.
  • 3/23/10 – Dayne West presented Zhang, Y. et al. (2009) The Paf1 complex is required for efficient transcription elongation by RNA polymerase I. PNAS 106, 2153-2158.
  • 3/16/10 – Sarah Barilovits presented Kowentz-Leutz, E. et al. (2010) Crosstalk between C/EBPβ phosphorylation, arginine methylation, and SWI/SNF/mediator implies an indexing of transcription factor code. EMBO Journal
  • 3/2/10 – Bhavita Patel presented Furuyama, T. and Henikoff, S. (2009) Centromeric nucleosomes induce positive DNA supercoils. Cell 138, 104-113.
  • 2/23/10 – Joeva Barrow presented Kwon, H.J. et al. (2009) Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol. Cell 137, 1213-1224.
  • 2/09/10 – Justin Runac presented Liu, B. et al. (2010) The polarisome is required for segregation and retrograde transport of protein aggregates. Cell 140, 257-267.
  • 2/02/10 – Tolunay Beker presented Ulbrich, C. et al. (2009) Mechanochemical removal of ribosome biogenesis factors from nascent 60S ribosomal subunits. Cell 138, 911-922.
  • 1/26/10 – Robert Ng presented Franz, H. et al. (2009) Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association. J. Biol. Chem. 284, 35049-35059.
  • 1/19/10 – Sushama Kamarajugadda presented Roux, J. et al. (2009) TGF-β1 inhibits CFTR-dependent cAMP-stimulated alveolar epithelial fluid transport via a PI3K-dependent mechanism. J. Biol. Chem. Papers in Press
  • 1/12/10 – Suzanne Farver presented Lo, K.-Y. et al. (2010) Ribosome stalk assembly required the dual-specificity phosphotase Yvh1 for the exchange of Mrt4 with P0. J. Cell Biol. 186, 849-862.

Fall 2009 Presentations

Topic: Enzyme Mechanisms

  • 12/7/09 – Mollie Martin presented Jang, G.-Y. et al. (2009) Transglutaminase 2 suppresses apoptosis by modulating caspase 3 and NF-ΚB activity in hypoxic tumor cells. Oncogene advance online publication
  • 12/1/09 – Jennifer Thompson presented Kolandaivelu, S. et al. (2009) AIPL1, a protein associated with childhood blindness, interacts with α-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly. J. Biol. Chem. 284, 30853-30861
  • 11/24/09 – River Ybarra presented Grassinger, J. et al. (2009) Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with α9β1 and α4β1 integrins. Blood 114, 49-59
  • 11/17/09 – Mukundh Balasubramanian presented Yang, X-c. et al. (2009) FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3’end processing of histone pre-mRNA’s. Molecular Cell 36, 267-278
  • 11/10/09 – Balu Avvaru his research in the McKenna Lab “Insights into the catalytic mechanism of human carbonic anhydrase II.”
  • 10/27/09 – Ryan Skehan presented Kraft, C. et al. (2008) Mature ribosomes are selectively degraded upon staration by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease. Nature Cell Biol. 10, 602-610
  • 10/20/09 – Ankita Chiraniya presented Gafni, J. et al. (2009) Calpain-1 cleaves and activates caspase-7. J. Biol. Chem. 284, 25441-25449
  • 10/13/09 – Kavitha Gnanasambandan presented Mukherjee, K. et al. (2008) CASK functions as a Mg2+-independent neurexin kinase. Cell 133, 328-339.
  • 10/6/09 – Bala Venkatakrishnan Wu, Y.I. et al. (2009) A genetically encoded photoactivatable Rac controls the motility of living cells. Nature 461, 104-108
  • 9/29/09 – Danel Gibson presented his work in the Schultz Lab “The Molecular Biology of Corneal Fibrosis”
  • 9/22/09 – Tina Halder presented Sapparapu, G. et al. (2009) Antigen-specific proteolysis by hybrid antibodies containing promiscuous proteolytic light chains paired with an antigen-binding heavy chain. J. Biol. Chem. 284, 24622-24633
  • 9/15/09 – Lisa Dyer presented Nakatani, J. et al. (2009) Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell 137, 1235-1246.
  • 9/8/09 – Katherine Sippel her research in the McKenna Lab “Mycoplasma p37: The tale of a protein in search of an identity.”
  • 9/1/08 – Dr. Ben Dunn presented his research “The ABCs of HIV-1 Protease”.

Spring 2009 Presentations

Topic: Epigenetics – Nature vs. Nurture

  • 4/28/09 – Tolunay Beker presented Xiao, A. et al. (2009) WSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity. Nature 457, 57-62.
  • 4/21/09 – Mukundh Balasubramanian presented McGowan, P.O.et al. (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience 12, 342-348.
  • 4/14/09 – Randy Jirtle, Ph.D., Professor, Duke University School of Medicine, presented his research “Epigenetics: the Inextricable Link Between Nature and Nurture”.
  • 4/7/09 – Jennifer Thompson presented Xie, W. et al. (2009) Histone H3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Mol. Cell 33, 417-427.
  • 3/31/09 – River Ybarra presented Colmone, A. et al. (2008) Leukemic cells create bone marrow niches that disrupt the behavior of normal hematopoetic progenitor cells. Science 322, 1861-1865.
  • 3/24/09 – Ryan Skehan presented Lubin, F.D. et al. (2008) Epigenetic regulation of bdnf gene transcription in the consolidation of fear memory. J. Neuroscience 28, 10576-10586.
  • 3/17/09 – Jeanne Quirit presented Mammoto, A. et al. (2009) A mechanoselective transcriptional mechanism that controls angiogenesis. Nature 457, 1103-1109.
  • 3/10/09 – Lauren Drouin presented Silva, L. et al. (2008) Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation. PLOS Pathogens 4(5), e1000071.
  • 3/3/09 – Lawrence Tartaglia presented Mikkelsen, T.S. et al. (2008) Dissecting direct reprogramming through integrative genomic analysis. Nature 454, 49-55.
  • 2/24/09 – Mollie Martin presented Lujambio, A. (2008) A microRNA DNA methylation signature for human cancer metastasis. PNAS 105, 13556-13561.
  • 2/17/09 – Sayak Mitter presented Varambally, S. et al. (2008) Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer. Science 322, 1695-1699.
  • 2/10/09 – Ying Li presented Han, X. et al. (2008) Tethering by lamin A stabilizes and targets the ING1 tumor suppressor. Nature Cell Biology 10, 1333-1340.
  • 2/3/09 – Daniel Gibson presented Weaver, I.C.G. et al. (2008) Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: Altering epigenetic marking later in life. J. Neuroscience 25, 11045-11054.
  • 1/27/09 – Kavitha Gnanasambandan presented Hansen, K.H. et al. (2008) A model for transmission of the H3K27me3 epigenetic mark. Nature Cell Biology 10, 1291-1300.
  • 1/20/09 – Ankita Chiraniya presented Alenghat, T. et al. (2008) Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature 456, 997-1000.
  • 1/13/09 – Robert Ng presented Vincenz, C. and Kerppola, T.K. (2008) Different polycomb group CBX family proteins associate with distinct regions of chromatin using nonhomologous protein sequences. PNAS 105, 16572-16577.
  • 1/6/09 – Bala Venkatakrishnan presented Meissner, A. et al. (2008) Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454, 766-770.

Fall 2008 Presentations

Topic: HIV and Viral Assembly

  • 12/9/08 – Balendu Avvaru presented Kaganovich, D., Kopito, R. and Frydman, J. (2008) Misfolded proteins partition between two distinct quality control compartments. Nature 454, 1089-1096.
  • 12/2/08 – Sujata (Tina) Halder presented Choi, E.Y. et al. (2008) Del-1, an Endogenous Leukocyte-Endothelial Adhesion Inhibitor, Limits Inflammatory Cell Recruitment. Science 322, 1101-1104.
  • 11/25/08 – Ada Ao presented Mercer J. and Helenius, H. (2008) Vaccinia Virus Uses Macropinocytosis and Apoptotic Mimicry to Enter Host Cells. Science 320, 531-535.
  • 11/18/08 – Lisa Dyer presented Wen, L. et al. (2008) Innate immunity and intestinal microbiata in the development of Type 1 diabetes. Nature 455, 1109-1113.
  • 11/13/08 – Wesley Sundquist, Ph.D., Professor, University of Utah, presented his research “Structural Biology and Biochemistry of HIV Assembly and Budding”.
  • 11/4/08 – Suzanne Farver presented Bartonova, V. et al. (2008) Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly competent quarternary structure of the capsid protein. J. Biol. Chem. Article in Press
  • 10/28/08 – Bing Yao presented Rauch, S. et al. (2008) Human Immunodeficiency Virus Type 1 Nef Recruits the Guanine Exchange Factor Vav1 via an Unexpected Interface into Plasma Membrane Microdomains for Association with p21-Activated Kinase 2 Activity. Journal of Virology 82, 2918-2929.
  • 10/21/08 – Katherine Sippel presented Wang, J.-H. et al. (2008) Macropinocytosis and cytoskeleton contribute to dendritic cell-mediated HIV-1 transmission to CD4+ cells. Virology Article in Press
  • 10/14/08 – Brittney Gurda presented Trajkovic, K. et al. (2008) Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes. Science 319, 1244-1247.
  • 10/7/08 – Carolina Pardo presented Carlton, J.G. et al. (2008) Differential Requirements for Alix and ESCRT-III in Cytokinesis and HIV-1 release. PNAS 105, 10541-10545
  • 9/30/08 – Sushama Kamarajugadda presented Strasner, A.B. et al. (2008) The Src Kinase Lck Facilitates Assembly of HIV-1 at the Plasma Membrane. J. Immuno. 181, 3706 -3713.
  • 9/23/08 – Dr. Ben Dunn presented his research “Global Infectious Diseases: HIV Protease Sequence Variability and Drug Resistance”.
  • 9/9/08 – Amanda Welch presented Dantas, G. et al. (2008) Bacteria subsisting on antibiotics. Science 320, 100 – 103.
  • 9/2/08 – John Domsic presented Ushioda, R. et al. (2008) ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER. Science 321, 569 – 572.

Spring 2008 Presentations

Topic: Antimicrobial Peptides

  • 4/22/08 – Ying Li presented Corbin, B.D. et al. (2008) Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses. Science 319, 962 – 965.
  • 4/15/08 – Guest speaker Dr. Michael Zasloff presented his research “So why don’t I get an infection when I bite my tongue: The silent role of innate immunity in human health”.
  • 4/1/08 – Bing Yao presented Greten, F.R. et al. (2007) NF-κB is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ. Cell 130, 918-931.
  • 3/25/08 – Sujata Halder presented Nakatsukasa, K. et al. (2008) Dissecting the ER-associated Degradation of a Misfolded Polytopic Membrane Protein. Cell 132, 102-112.
  • 3/18/08 – Dan Gibson presented Karnik, S.K. et al. (2007) Menin Controls Growth of Pancreatic β-Cells in Pregnant Mice and Promotes Gestational Diabetes Mellitus. Science 318, 806 – 809.
  • 3/4/08 – Judy Hwang presented Ryu, J.-H. et al. (2008) Innate Immune Homeostasis by the Homeobox Gene Caudal and Commensal-Gut Mutualism in Drosophila. Science 319, 777 – 782.
  • 2/26/08 – Tolunay Beker presented Foster, S.L. et al. (2007) Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 447, 972-978.
  • 2/19/08 – Suzanne Farver presented Pistolesi, S. et al. (2007) Membrane Insertion and Bilayer Perturbation by Antimicrobial Peptide CM15. Biophys. J. 93, 1651-1660.
  • 2/12/08 – Lisa Dyer presented Overholtzer, M. et al. (2007) A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion. Cell 131, 966-979.
  • 2/05/08 – Carolina Pardo presented Lande, R. et al. (2007) Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449, 564-569.
  • 1/29/08 – Balu Avvaru presented Pajerowski, J.D. et al. (2007) Physical plasticity of the nucleus in stem cell differentiation. Proc. Natl. Acad. Sci. USA 104, 15619-15624
  • 1/22/08 – Katherine Sippel presented Nishida, N. et al. (2007) Interaction of Magainin-PGLa Peptide with Membranes: Insight into the Mechanism of Synergism. Biochemistry 46, 14284-14290.
  • 1/15/08 – Justin Bickford presented Gupta, M. and Copeland, P.R. (2007) Functional Analysis of the Interplay between Translation Termination, Selenocytein Codon Context, and Slenocystein Insertion Sequence-binding Protein 2. J. Biol. Chem. 282, 36797-36807.
  • 1/08/08 – Santhi Pondugula presented Takahashi, K. et al. (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell 131, 861-872.

Fall 2007 Presentations

  • 12/4/07 – Brian Fuller presented Pentcheva-Hong, T. et al. (2007) Programmed Death-1 Concentration at the Immunological Synapse is Determined by Ligand Affinity and Availability. Proc. Natl. Acad. Sci. USA 104, 17,765-17,770
  • 11/27/07 – Nan Su presented Dong, J. et al. (2007) Elucidation of a Universal Size-control Mechanism in Drosophila and Mammals. Cell 130, 1120-1133
  • 11/20/07 – Ada Ao presented Arockia Jeyaprakash, A. et al. (2007) Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together. Cell 131, 271-285
  • 11/13/07 – John Domsic presented Kang, B.H. et al. (2007) Regulation of Tumor Cell Mitochondrial Homeostasis by an Organelle-Specific Hsp90 Chaperone Network. Cell 131, 257-270
  • 11/6/07 – Altin Gjymishka presented a talk on his research in the Kilberg Lab entitled “Distinct Transcriptional Regulation of Human Neutral Amino Acid Transporter SNAT2 by Endoplasmic Reticulum Stress and Amino Acid Limitation”.
  • 10/29/07 – Brittney Gurda presented Luke, C.J. et al. (2007) An Intracellular Serpin Regulates Necrosis by Inhibiting the Induction and Sequelae of Lysosomal Injury Cell 130, 1108-1119
  • 10/23/07 – Zhuo Zhou presented Cheah, M.T. et al. (2007) Control of Alternative RNA Splicing and Gene Expression by Eukaryotic Riboswitches. Nature 447, 497-500.
  • 10/16/07 – Melissa Marzahn presented her research in the Dunn Lab entitled “Characterization of Plasmepsins from the Malaria Parasite Plasmodium falciparum”.
  • 10/9/07 – Suhashni Gopalakrishnan presented Denchi, E.L. and de Lange, T. (2007) Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1 Nature 448, 1068-1071.
  • 10/2/07 – Amanda Welch presented Ortlund, E.A. et al. (2007) Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis. Science 317, 1544-1548.
  • 9/25/07 – Nicolette Case presented Kovtun, I.V. et al. (2007) OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature 447, 447-45.
  • 9/18/07 – Marsha Bush presented Nakamura ,T. et al. (2007) Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts. Cell 130, 811-823.
  • 9/11/07 – Jesse Kay presented Schug, T.T. et al. (2007) Opposing Effects of Retinoic Acid on Cell Growth Result from Alternate Activation of Two Different Nuclear Receptors. Cell 129, 723-733.