Mavis Agbandje-Mckenna

Mavis Agbandje-Mckenna,

PROFESSOR

Department: MD-BIOCHEMISTRY-GENERAL
Business Phone: (352) 294-8393
Business Email: mckenna@ufl.edu

Teaching Profile

Courses Taught
2018-2019,2021
BCH6877 Recent Advances in Structural Biology
2007-2020
BCH6744L Molecular Structure Determination by X-Ray Crystallography Laboratory
2013-2014,2016-2019
GMS6001 Fundamentals of Biomedical Sciences I
2018
GMS7980 Research for Doctoral Dissertation
2018
CHM7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2016
GMS6251 Molecular Therapy I ? Vectors and Molecular Mechanisms
2008,2011-2016
BCH6875 Crystallography and Cryo-Electron Microscopy
2015
BCH4905 Biochemistry Senior Research
2009-2010
IDH4917 Undergrad Research

Publications

2022
Age-stratified adeno-associated virus serotype 3 neutralizing and total antibody prevalence in hemophilia A patients from India.
Journal of medical virology. 94(9):4542-4547 [DOI] 10.1002/jmv.27859. [PMID] 35577570.
2022
Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity.
Journal of virology. 96(11) [DOI] 10.1128/jvi.00335-22. [PMID] 35532224.
2022
Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants.
Journal of virology. 96(3) [DOI] 10.1128/JVI.01251-21. [PMID] 34757842.
2021
Adeno-associated Virus (AAV) Capsid Chimeras with Enhanced Infectivity Reveal a Core Element in the AAV Genome Critical for both Cell Transduction and Capsid Assembly.
Journal of virology. 95(7) [DOI] 10.1128/JVI.02023-20. [PMID] 33441336.
2021
Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment.
Journal of virology. 95(19) [DOI] 10.1128/JVI.00843-21. [PMID] 34260280.
2021
Adeno-associated virus capsid assembly is divergent and stochastic.
Nature communications. 12(1) [DOI] 10.1038/s41467-021-21935-5. [PMID] 33712599.
2021
Characterization of the GBoV1 Capsid and Its Antibody Interactions.
Viruses. 13(2) [DOI] 10.3390/v13020330. [PMID] 33672786.
2021
Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2.
Journal of structural biology. 213(4) [DOI] 10.1016/j.jsb.2021.107795. [PMID] 34509611.
2021
Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features.
Viruses. 13(1) [DOI] 10.3390/v13010101. [PMID] 33450892.
2021
I Am Here: It Took a Global Village.
Annual review of virology. 8(1):1-21 [DOI] 10.1146/annurev-virology-091919-104940. [PMID] 34586869.
2021
Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids.
Journal of virology. 95(19) [DOI] 10.1128/JVI.00773-21. [PMID] 34287038.
2021
Parvovirus Capsid-Antibody Complex Structures Reveal Conservation of Antigenic Epitopes Across the Family.
Viral immunology. 34(1):3-17 [DOI] 10.1089/vim.2020.0022. [PMID] 32315582.
2021
pH-Induced Conformational Changes of Human Bocavirus Capsids.
Journal of virology. 95(8) [DOI] 10.1128/JVI.02329-20. [PMID] 33472934.
2021
Prevalence of Adeno-Associated Virus 3 Capsid Binding and Neutralizing Antibodies in Healthy and Hemophilia B Individuals from India.
Human gene therapy. 32(9-10):451-457 [DOI] 10.1089/hum.2020.258. [PMID] 33207962.
2021
Receptor Switching in Newly Evolved Adeno-associated Viruses.
Journal of virology. 95(19) [DOI] 10.1128/JVI.00587-21. [PMID] 34232726.
2021
Structural Study of Aavrh.10 Receptor and Antibody Interactions.
Journal of virology. 95(23) [DOI] 10.1128/JVI.01249-21. [PMID] 34549984.
2020
Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking.
Viruses. 12(6) [DOI] 10.3390/v12060668. [PMID] 32575696.
2020
Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2.
Molecular therapy. Methods & clinical development. 17:1139-1154 [DOI] 10.1016/j.omtm.2020.05.004. [PMID] 32490035.
2020
Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies.
Molecular therapy. Methods & clinical development. 19:362-373 [DOI] 10.1016/j.omtm.2020.10.001. [PMID] 33145372.
2020
Characterization of an intermolecular quaternary interaction between discrete segments of the Streptococcus mutans adhesin P1 by NMR spectroscopy.
The FEBS journal. 287(12):2597-2611 [DOI] 10.1111/febs.15158. [PMID] 31782893.
2020
Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach.
Journal of virology. 94(19) [DOI] 10.1128/JVI.00976-20. [PMID] 32669336.
2020
Comparative Analysis of the Capsid Structures of AAVrh.10, AAVrh.39, and AAV8.
Journal of virology. 94(6) [DOI] 10.1128/JVI.01769-19. [PMID] 31826994.
2020
Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing.
Molecular therapy. Nucleic acids. 20:451-458 [DOI] 10.1016/j.omtn.2020.03.009. [PMID] 32276210.
2020
Evolution of dependoparvoviruses across geological timescales-implications for design of AAV-based gene therapy vectors.
Virus evolution. 6(2) [DOI] 10.1093/ve/veaa043. [PMID] 32913662.
2020
Geminivirus structure and assembly.
Advances in virus research. 108:1-32 [DOI] 10.1016/bs.aivir.2020.09.005. [PMID] 33837714.
2020
Impact of Natural or Synthetic Singletons in the Capsid of Human Bocavirus 1 on Particle Infectivity and Immunoreactivity.
Journal of virology. 94(11) [DOI] 10.1128/JVI.00170-20. [PMID] 32213611.
2020
Molecular biology and structure of a novel penaeid shrimp densovirus elucidate convergent parvoviral host capsid evolution.
Proceedings of the National Academy of Sciences of the United States of America. 117(33):20211-20222 [DOI] 10.1073/pnas.2008191117. [PMID] 32747554.
2020
Pre-arrayed Pan-AAV Peptide Display Libraries for Rapid Single-Round Screening.
Molecular therapy : the journal of the American Society of Gene Therapy. 28(4):1016-1032 [DOI] 10.1016/j.ymthe.2020.02.009. [PMID] 32105604.
2020
Resolving heterogeneous macromolecular assemblies by Orbitrap-based single-particle charge detection mass spectrometry.
Nature methods. 17(4):395-398 [DOI] 10.1038/s41592-020-0770-7. [PMID] 32152501.
2020
Restoring the natural tropism of AAV2 vectors for human liver.
Science translational medicine. 12(560) [DOI] 10.1126/scitranslmed.aba3312. [PMID] 32908003.
2020
Site-Directed Mutagenesis Improves the Transduction Efficiency of Capsid Library-Derived Recombinant AAV Vectors.
Molecular therapy. Methods & clinical development. 17:545-555 [DOI] 10.1016/j.omtm.2020.03.007. [PMID] 32258217.
2020
Structural characterization of a bat Adeno-associated virus capsid.
Journal of structural biology. 211(2) [DOI] 10.1016/j.jsb.2020.107547. [PMID] 32522552.
2020
Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology.
Viruses. 12(6) [DOI] 10.3390/v12060653. [PMID] 32560452.
2020
Structure comparison of the chimeric AAV2.7m8 vector with parental AAV2.
Journal of structural biology. 209(2) [DOI] 10.1016/j.jsb.2019.107433. [PMID] 31859208.
2019
Adeno-Associated Virus VP1u Exhibits Protease Activity.
Viruses. 11(5) [DOI] 10.3390/v11050399. [PMID] 31035643.
2019
An Ancient Lineage of Highly Divergent Parvoviruses Infects both Vertebrate and Invertebrate Hosts.
Viruses. 11(6) [DOI] 10.3390/v11060525. [PMID] 31174309.
2019
High-Resolution Structural Characterization of a New Adeno-associated Virus Serotype 5 Antibody Epitope toward Engineering Antibody-Resistant Recombinant Gene Delivery Vectors.
Journal of virology. 93(1) [DOI] 10.1128/JVI.01394-18. [PMID] 30333169.
2019
ICTV Virus Taxonomy Profile: Parvoviridae.
The Journal of general virology. 100(3):367-368 [DOI] 10.1099/jgv.0.001212. [PMID] 30672729.
2019
Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue.
Molecular therapy : the journal of the American Society of Gene Therapy. 27(3):611-622 [DOI] 10.1016/j.ymthe.2019.01.015. [PMID] 30772143.
2019
Twenty-Five Years of Structural Parvovirology.
Viruses. 11(4) [DOI] 10.3390/v11040362. [PMID] 31010002.
2019
XVIIth International Parvovirus Workshop.
Human gene therapy. 30(3):252-256 [DOI] 10.1089/hum.2019.29084.mam. [PMID] 30807259.
2018
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.
Brain : a journal of neurology. 141(7):2014-2031 [DOI] 10.1093/brain/awy126. [PMID] 29788236.
2018
A Rationally Engineered Capsid Variant of AAV9 for Systemic CNS-Directed and Peripheral Tissue-Detargeted Gene Delivery in Neonates.
Molecular therapy. Methods & clinical development. 9:234-246 [DOI] 10.1016/j.omtm.2018.03.004. [PMID] 29766031.
2018
AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognition.
Virology. 518:369-376 [DOI] 10.1016/j.virol.2018.03.007. [PMID] 29604478.
2018
Assembly and disassembly intermediates of maize streak geminivirus.
Virology. 525:224-236 [DOI] 10.1016/j.virol.2018.09.011. [PMID] 30300759.
2018
Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses. 10(1) [DOI] 10.3390/v10010022. [PMID] 29300333.
2018
Atomic structure of a rationally engineered gene delivery vector, AAV2.5.
Journal of structural biology. 203(3):236-241 [DOI] 10.1016/j.jsb.2018.05.004. [PMID] 29775653.
2018
Creating an arsenal of Adeno-associated virus (AAV) gene delivery stealth vehicles.
PLoS pathogens. 14(5) [DOI] 10.1371/journal.ppat.1006929. [PMID] 29723270.
2018
Endogenous amdoparvovirus-related elements reveal insights into the biology and evolution of vertebrate parvoviruses.
Virus evolution. 4(2) [DOI] 10.1093/ve/vey026. [PMID] 30443409.
2018
Optimizing the Targeting of Mouse Parvovirus 1 to Murine Melanoma Selects for Recombinant Genomes and Novel Mutations in the Viral Capsid Gene.
Viruses. 10(2) [DOI] 10.3390/v10020054. [PMID] 29385689.
2018
Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-06076-6. [PMID] 30194371.
2017
Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction.
Viruses. 9(11) [DOI] 10.3390/v9110321. [PMID] 29084163.
2017
Direct Head-to-Head Evaluation of Recombinant Adeno-associated Viral Vectors Manufactured in Human versus Insect Cells.
Molecular therapy : the journal of the American Society of Gene Therapy. 25(12):2661-2675 [DOI] 10.1016/j.ymthe.2017.08.003. [PMID] 28890324.
2017
OneBac 2.0: Sf9 Cell Lines for Production of AAV1, AAV2, and AAV8 Vectors with Minimal Encapsidation of Foreign DNA.
Human gene therapy methods. 28(1):15-22 [DOI] 10.1089/hgtb.2016.164. [PMID] 28125901.
2017
Parvovirus Capsid Structures Required for Infection: Mutations Controlling Receptor Recognition and Protease Cleavages.
Journal of virology. 91(2) [DOI] 10.1128/JVI.01871-16. [PMID] 27847360.
2017
Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS.
Molecular therapy. Nucleic acids. 8:184-197 [DOI] 10.1016/j.omtn.2017.06.011. [PMID] 28918020.
2017
Structural Insights into Human Bocaparvoviruses.
Journal of virology. 91(11) [DOI] 10.1128/JVI.00261-17. [PMID] 28331084.
2017
Structure-guided evolution of antigenically distinct adeno-associated virus variants for immune evasion.
Proceedings of the National Academy of Sciences of the United States of America. 114(24):E4812-E4821 [DOI] 10.1073/pnas.1704766114. [PMID] 28559317.
2017
The Good That Viruses Do.
Annual review of virology. 4(1):iii-v [DOI] 10.1146/annurev-vi-04-071217-100011. [PMID] 28961414.
2017
Thermal Stability as a Determinant of AAV Serotype Identity.
Molecular therapy. Methods & clinical development. 6:171-182 [DOI] 10.1016/j.omtm.2017.07.003. [PMID] 28828392.
2016
Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site.
Journal of virology. 90(11):5219-5230 [DOI] 10.1128/JVI.00161-16. [PMID] 26962225.
2016
Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
Journal of virology. 90(19):8542-51 [DOI] 10.1128/JVI.00575-16. [PMID] 27440903.
2016
Cryoannealing-induced space-group transition of crystals of the carbonic anhydrase psCA3.
Acta crystallographica. Section F, Structural biology communications. 72(Pt 7):573-7 [DOI] 10.1107/S2053230X16009286. [PMID] 27380376.
2016
Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer.
Molecular therapy : the journal of the American Society of Gene Therapy. 24(1):53-65 [DOI] 10.1038/mt.2015.134. [PMID] 26220272.
2016
Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies.
Journal of virological methods. 236:105-110 [DOI] 10.1016/j.jviromet.2016.07.009. [PMID] 27424005.
2016
Germline viral “fossils” guide in silico reconstruction of a mid-Cenozoic era marsupial adeno-associated virus.
Scientific reports. 6 [DOI] 10.1038/srep28965. [PMID] 27377618.
2016
Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors.
Journal of virology. 90(8):4215-4231 [DOI] 10.1128/JVI.00200-16. [PMID] 26865709.
2016
Mapping Antigenic Epitopes on the Human Bocavirus Capsid.
Journal of virology. 90(9):4670-4680 [DOI] 10.1128/JVI.02998-15. [PMID] 26912619.
2016
Mutants at the 2-Fold Interface of Adeno-associated Virus Type 2 (AAV2) Structural Proteins Suggest a Role in Viral Transcription for AAV Capsids.
Journal of virology. 90(16):7196-7204 [DOI] 10.1128/JVI.00493-16. [PMID] 27252527.
2016
The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis.
Biochemistry. 55(33):4642-53 [DOI] 10.1021/acs.biochem.6b00243. [PMID] 27439028.
2015
Adeno-associated virus serotype 1 (AAV1)- and AAV5-antibody complex structures reveal evolutionary commonalities in parvovirus antigenic reactivity.
Journal of virology. 89(3):1794-808 [DOI] 10.1128/JVI.02710-14. [PMID] 25410874.
2015
Identification and mutagenesis of the adeno-associated virus 5 sialic acid binding region.
Journal of virology. 89(3):1660-72 [DOI] 10.1128/JVI.02503-14. [PMID] 25410855.
2015
Parvovirus Family Conundrum: What Makes a Killer?
Annual review of virology. 2(1):425-50 [DOI] 10.1146/annurev-virology-100114-055150. [PMID] 26958923.
2015
Site-Directed Mutagenesis of Surface-Exposed Lysine Residues Leads to Improved Transduction by AAV2, But Not AAV8, Vectors in Murine Hepatocytes In Vivo.
Human gene therapy methods. 26(6):211-20 [DOI] 10.1089/hgtb.2015.115. [PMID] 26421998.
2015
Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration.
Acta crystallographica. Section D, Biological crystallography. 71(Pt 8):1745-56 [DOI] 10.1107/S1399004715012183. [PMID] 26249355.
2015
Structure of an enteric pathogen, bovine parvovirus.
Journal of virology. 89(5):2603-14 [DOI] 10.1128/JVI.03157-14. [PMID] 25520501.
2015
Structure of neurotropic adeno-associated virus AAVrh.8.
Journal of structural biology. 192(1):21-36 [DOI] 10.1016/j.jsb.2015.08.017. [PMID] 26334681.
2014
A simplified purification protocol for recombinant adeno-associated virus vectors.
Molecular therapy. Methods & clinical development. 1 [DOI] 10.1038/mtm.2014.34. [PMID] 26015974.
2014
Adeno-associated virus capsid proteins may play a role in transcription and second-strand synthesis of recombinant genomes.
Journal of virology. 88(2):1071-9 [DOI] 10.1128/JVI.02093-13. [PMID] 24198419.
2014
Defining the stoichiometry and cargo load of viral and bacterial nanoparticles by Orbitrap mass spectrometry.
Journal of the American Chemical Society. 136(20):7295-9 [DOI] 10.1021/ja502616y. [PMID] 24787140.
2014
Diversity of environmental single-stranded DNA phages revealed by PCR amplification of the partial major capsid protein.
The ISME journal. 8(10):2093-103 [DOI] 10.1038/ismej.2014.43. [PMID] 24694711.
2014
Gene transfer properties and structural modeling of human stem cell-derived AAV.
Molecular therapy : the journal of the American Society of Gene Therapy. 22(9):1625-34 [DOI] 10.1038/mt.2014.107. [PMID] 24925207.
2014
Mapping the AAV Capsid Host Antibody Response toward the Development of Second Generation Gene Delivery Vectors.
Frontiers in immunology. 5 [DOI] 10.3389/fimmu.2014.00009. [PMID] 24523720.
2014
OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy.
Human gene therapy. 25(3):212-22 [DOI] 10.1089/hum.2013.184. [PMID] 24299301.
2014
Parvovirus glycan interactions.
Current opinion in virology. 7:108-18 [DOI] 10.1016/j.coviro.2014.05.007. [PMID] 25047752.
2014
Profiling of glycan receptors for minute virus of mice in permissive cell lines towards understanding the mechanism of cell recognition.
PloS one. 9(1) [DOI] 10.1371/journal.pone.0086909. [PMID] 24475195.
2014
The family Parvoviridae.
Archives of virology. 159(5):1239-47 [DOI] 10.1007/s00705-013-1914-1. [PMID] 24212889.
2014
The ins and outs of viral infection: keystone meeting review.
Viruses. 6(9):3652-62 [DOI] 10.3390/v6093652. [PMID] 25256395.
2014
The structure of AAVrh32.33, a novel gene delivery vector.
Journal of structural biology. 186(2):308-17 [DOI] 10.1016/j.jsb.2014.03.020. [PMID] 24704217.
2014
Tunable protease-activatable virus nanonodes.
ACS nano. 8(5):4740-6 [DOI] 10.1021/nn500550q. [PMID] 24796495.
2014
Vector design Tour de Force: integrating combinatorial and rational approaches to derive novel adeno-associated virus variants.
Molecular therapy : the journal of the American Society of Gene Therapy. 22(11):1900-9 [DOI] 10.1038/mt.2014.139. [PMID] 25048217.
2013
Adeno-associated virus structural biology as a tool in vector development.
Future virology. 8(12):1183-1199 [PMID] 24533032.
2013
Capsid antibodies to different adeno-associated virus serotypes bind common regions.
Journal of virology. 87(16):9111-24 [DOI] 10.1128/JVI.00622-13. [PMID] 23760240.
2013
Characterization of naturally-occurring humoral immunity to AAV in sheep.
PloS one. 8(9) [DOI] 10.1371/journal.pone.0075142. [PMID] 24086458.
2013
Comparative analysis of adeno-associated virus capsid stability and dynamics.
Journal of virology. 87(24):13150-60 [DOI] 10.1128/JVI.01415-13. [PMID] 24067976.
2013
Construction, expression, and purification of recombinant αVβ5 integrin.
Protein expression and purification. 89(2):225-31 [DOI] 10.1016/j.pep.2013.04.002. [PMID] 23583935.
2013
Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency.
The Journal of biological chemistry. 288(40):28814-23 [DOI] 10.1074/jbc.M113.482380. [PMID] 23940044.
2013
Mapping the structural determinants responsible for enhanced T cell activation to the immunogenic adeno-associated virus capsid from isolate rhesus 32.33.
Journal of virology. 87(17):9473-85 [DOI] 10.1128/JVI.00596-13. [PMID] 23720715.
2013
Molecular cloning, overexpression, and an efficient one-step purification of α5β1 integrin.
Protein expression and purification. 92(1):21-8 [DOI] 10.1016/j.pep.2013.08.013. [PMID] 23993979.
2013
Optimization of the capsid of recombinant adeno-associated virus 2 (AAV2) vectors: the final threshold?
PloS one. 8(3) [DOI] 10.1371/journal.pone.0059142. [PMID] 23527116.
2013
Structural characterization of H-1 parvovirus: comparison of infectious virions to empty capsids.
Journal of virology. 87(9):5128-40 [DOI] 10.1128/JVI.03416-12. [PMID] 23449783.
2013
Structural insights into adeno-associated virus serotype 5.
Journal of virology. 87(20):11187-99 [DOI] 10.1128/JVI.00867-13. [PMID] 23926356.
2013
Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking.
Journal of virology. 87(9):4974-84 [DOI] 10.1128/JVI.02524-12. [PMID] 23427155.
2013
Targeting photoreceptors via intravitreal delivery using novel, capsid-mutated AAV vectors.
PloS one. 8(4) [DOI] 10.1371/journal.pone.0062097. [PMID] 23637972.
2012
Evidence for pH-dependent protease activity in the adeno-associated virus capsid.
Journal of virology. 86(21):11877-85 [DOI] 10.1128/JVI.01717-12. [PMID] 22915820.
2012
Examining the cross-reactivity and neutralization mechanisms of a panel of mAbs against adeno-associated virus serotypes 1 and 5.
The Journal of general virology. 93(Pt 2):347-355 [DOI] 10.1099/vir.0.035113-0. [PMID] 22071509.
2012
Functional glycomic analysis of human milk glycans reveals the presence of virus receptors and embryonic stem cell biomarkers.
The Journal of biological chemistry. 287(53):44784-99 [DOI] 10.1074/jbc.M112.425819. [PMID] 23115247.
2012
High-efficiency transduction of human monocyte-derived dendritic cells by capsid-modified recombinant AAV2 vectors.
Vaccine. 30(26):3908-17 [DOI] 10.1016/j.vaccine.2012.03.079. [PMID] 22497875.
2012
Identification of the galactose binding domain of the adeno-associated virus serotype 9 capsid.
Journal of virology. 86(13):7326-33 [DOI] 10.1128/JVI.00448-12. [PMID] 22514350.
2012
Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.
Protein engineering, design & selection : PEDS. 25(7):347-55 [DOI] 10.1093/protein/gzs027. [PMID] 22691706.
2012
Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8.
Journal of virology. 86(15):7739-51 [DOI] 10.1128/JVI.00218-12. [PMID] 22593150.
2012
Mining the protein data bank to differentiate error from structural variation in clustered static structures: an examination of HIV protease.
Viruses. 4(3):348-62 [DOI] 10.3390/v4030348. [PMID] 22590675.
2012
Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector.
Molecular therapy : the journal of the American Society of Gene Therapy. 20(2):443-55 [DOI] 10.1038/mt.2011.237. [PMID] 22068425.
2012
Production, purification, crystallization and structure determination of H-1 Parvovirus.
Acta crystallographica. Section F, Structural biology and crystallization communications. 68(Pt 12):1571-6 [DOI] 10.1107/S1744309112045563. [PMID] 23192051.
2012
Random Insertion of mCherry Into VP3 Domain of Adeno-associated Virus Yields Fluorescent Capsids With no Loss of Infectivity.
Molecular therapy. Nucleic acids. 1(11) [DOI] 10.1038/mtna.2012.46. [PMID] 23629029.
2012
Single amino acid modification of adeno-associated virus capsid changes transduction and humoral immune profiles.
Journal of virology. 86(15):7752-9 [DOI] 10.1128/JVI.00675-12. [PMID] 22593151.
2012
Structural insight into the unique properties of adeno-associated virus serotype 9.
Journal of virology. 86(12):6947-58 [DOI] 10.1128/JVI.07232-11. [PMID] 22496238.
2012
The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing.
Journal of virology. 86(17):9396-408 [DOI] 10.1128/JVI.00209-12. [PMID] 22718833.
2011
AAV capsid structure and cell interactions.
Methods in molecular biology (Clifton, N.J.). 807:47-92 [DOI] 10.1007/978-1-61779-370-7_3. [PMID] 22034026.
2011
Current opinion in virology: structural virology.
Current opinion in virology. 1(2):81-3 [DOI] 10.1016/j.coviro.2011.07.001. [PMID] 22440620.
2011
Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer.
Molecular therapy : the journal of the American Society of Gene Therapy. 19(6):1070-8 [DOI] 10.1038/mt.2011.22. [PMID] 21364538.
2011
Insights into Mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein.
Proteins. 79(2):528-36 [DOI] 10.1002/prot.22900. [PMID] 21117240.
2011
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina.
Molecular therapy : the journal of the American Society of Gene Therapy. 19(2):293-301 [DOI] 10.1038/mt.2010.234. [PMID] 21045809.
2011
Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.
Journal of virology. 85(22):11791-9 [DOI] 10.1128/JVI.05305-11. [PMID] 21900159.
2011
The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice.
The Journal of clinical investigation. 121(6):2427-35 [DOI] 10.1172/JCI57367. [PMID] 21576824.
2010
A short, strong hydrogen bond in the active site of human carbonic anhydrase II.
Biochemistry. 49(2):249-51 [DOI] 10.1021/bi902007b. [PMID] 20000378.
2010
BAAV transcytosis requires an interaction with beta-1-4 linked- glucosamine and gp96.
PloS one. 5(3) [DOI] 10.1371/journal.pone.0009336. [PMID] 20231878.
2010
Emerging from pseudo-symmetry: the redetermination of human carbonic anhydrase II in monoclinic P2(1) with a doubled a axis.
Acta crystallographica. Section D, Biological crystallography. 66(Pt 8):950-2 [DOI] 10.1107/S0907444910023723. [PMID] 20693695.
2010
Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae.
Journal of virology. 84(12):5880-9 [DOI] 10.1128/JVI.02719-09. [PMID] 20375175.
2010
Human hepatocyte growth factor receptor is a cellular coreceptor for adeno-associated virus serotype 3.
Human gene therapy. 21(12):1741-7 [DOI] 10.1089/hum.2010.075. [PMID] 20545554.
2010
Little vector, big gene transduction: fragmented genome reassembly of adeno-associated virus.
Molecular therapy : the journal of the American Society of Gene Therapy. 18(1):6-8 [DOI] 10.1038/mt.2009.280. [PMID] 20048740.
2010
Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle.
Nature biotechnology. 28(1):79-82 [DOI] 10.1038/nbt.1599. [PMID] 20037580.
2010
Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
Biochemistry. 49(30):6394-9 [DOI] 10.1021/bi1007645. [PMID] 20578724.
2010
Structural characterization of the dual glycan binding adeno-associated virus serotype 6.
Journal of virology. 84(24):12945-57 [DOI] 10.1128/JVI.01235-10. [PMID] 20861247.
2010
Structure of a monoclinic polymorph of human carbonic anhydrase II with a doubled a axis.
Acta crystallographica. Section D, Biological crystallography. 66(Pt 5):628-34 [DOI] 10.1107/S0907444910006797. [PMID] 20445238.
2010
Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes.
Acta crystallographica. Section D, Biological crystallography. 66(Pt 3):233-42 [DOI] 10.1107/S0907444909054298. [PMID] 20179334.
2010
Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core.
The Journal of biological chemistry. 285(41):31399-407 [DOI] 10.1074/jbc.M110.168211. [PMID] 20667821.
2010
Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II.
The journal of physical chemistry letters. 1(19):2898-2902 [PMID] 20976122.
2009
A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection.
Proceedings of the National Academy of Sciences of the United States of America. 106(10):3946-51 [DOI] 10.1073/pnas.0813207106. [PMID] 19234115.
2009
Adeno-associated virus capsid serotype identification: Analytical methods development and application.
Journal of virological methods. 159(2):167-77 [DOI] 10.1016/j.jviromet.2009.03.020. [PMID] 19447508.
2009
Adeno-associated virus capsid structure drives CD4-dependent CD8+ T cell response to vector encoded proteins.
Journal of immunology (Baltimore, Md. : 1950). 182(10):6051-60 [DOI] 10.4049/jimmunol.0803965. [PMID] 19414756.
2009
Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network.
Biochemistry. 48(31):7365-72 [DOI] 10.1021/bi9007512. [PMID] 19583303.
2009
Cloning, expression, purification, crystallization and preliminary X-ray analysis of Mycoplasma genitalium protein MG289.
Acta crystallographica. Section F, Structural biology and crystallization communications. 65(Pt 9):910-2 [DOI] 10.1107/S1744309109030565. [PMID] 19724130.
2009
Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank.
Acta crystallographica. Section D, Biological crystallography. 65(Pt 3):294-6 [DOI] 10.1107/S0907444908041632. [PMID] 19237752.
2009
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.
Biochemistry. 48(6):1322-31 [DOI] 10.1021/bi802035f. [PMID] 19170619.
2009
Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium.
Molecular therapy : the journal of the American Society of Gene Therapy. 17(12):2067-77 [DOI] 10.1038/mt.2009.155. [PMID] 19603002.
2009
Heparin binding induces conformational changes in Adeno-associated virus serotype 2.
Journal of structural biology. 165(3):146-56 [DOI] 10.1016/j.jsb.2008.12.002. [PMID] 19121398.
2009
High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design.
Acta crystallographica. Section F, Structural biology and crystallization communications. 65(Pt 10):992-5 [DOI] 10.1107/S1744309109036665. [PMID] 19851004.
2009
Naturally occurring singleton residues in AAV capsid impact vector performance and illustrate structural constraints.
Gene therapy. 16(12):1416-28 [DOI] 10.1038/gt.2009.101. [PMID] 19727141.
2009
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9.
Acta crystallographica. Section F, Structural biology and crystallization communications. 65(Pt 7):715-8 [DOI] 10.1107/S1744309109021460. [PMID] 19574648.
2009
Structural insights into the extracytoplasmic thiamine-binding lipoprotein p37 of Mycoplasma hyorhinis.
Journal of bacteriology. 191(8):2585-92 [DOI] 10.1128/JB.01680-08. [PMID] 19233924.
2008
An extension of the Minute Virus of Mice tissue tropism.
Virology. 379(2):245-55 [DOI] 10.1016/j.virol.2008.06.042. [PMID] 18684479.
2008
Assembly and structural analysis of a covalently closed nano-scale DNA cage.
Nucleic acids research. 36(4):1113-9 [PMID] 18096620.
2008
Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation.
Journal of medicinal chemistry. 51(4):852-60 [DOI] 10.1021/jm701170f. [PMID] 18215016.
2008
Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles.
Molecular therapy : the journal of the American Society of Gene Therapy. 16(7):1252-1260 [DOI] 10.1038/mt.2008.100. [PMID] 28178482.
2008
Entrapment of carbon dioxide in the active site of carbonic anhydrase II.
The Journal of biological chemistry. 283(45):30766-71 [DOI] 10.1074/jbc.M805353200. [PMID] 18768466.
2008
Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.
Biochemistry. 47(10):3174-84 [DOI] 10.1021/bi702385k. [PMID] 18266323.
2008
Molecular characterization of the heparin-dependent transduction domain on the capsid of a novel adeno-associated virus isolate, AAV(VR-942).
Journal of virology. 82(17):8911-6 [DOI] 10.1128/JVI.00672-08. [PMID] 18524816.
2008
Neurovirulence of polytropic murine retrovirus is influenced by two separate regions on opposite sides of the envelope protein receptor binding domain.
Journal of virology. 82(17):8906-10 [DOI] 10.1128/JVI.02134-07. [PMID] 18579597.
2008
Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.
Proceedings of the National Academy of Sciences of the United States of America. 105(22):7827-32 [DOI] 10.1073/pnas.0802866105. [PMID] 18511559.
2008
Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37.
Acta crystallographica. Section D, Biological crystallography. 64(Pt 11):1172-8 [DOI] 10.1107/S0907444908030175. [PMID] 19020356.
2008
Surface loop dynamics in adeno-associated virus capsid assembly.
Journal of virology. 82(11):5178-89 [DOI] 10.1128/JVI.02721-07. [PMID] 18367523.
2008
The role of the adeno-associated virus capsid in gene transfer.
Methods in molecular biology (Clifton, N.J.). 437:51-91 [DOI] 10.1007/978-1-59745-210-6_2. [PMID] 18369962.
2008
Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression.
Virology. 381(2):194-202 [DOI] 10.1016/j.virol.2008.08.027. [PMID] 18834608.
2007
A dual role of EGFR protein tyrosine kinase signaling in ubiquitination of AAV2 capsids and viral second-strand DNA synthesis.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(7):1323-30 [PMID] 17440440.
2007
Analysis of binding interactions of pepsin inhibitor-3 to mammalian and malarial aspartic proteases.
Biochemistry. 46(49):14198-205 [PMID] 18004881.
2007
Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism.
Biochemistry. 46(11):2930-7 [PMID] 17319692.
2007
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7.
Acta crystallographica. Section F, Structural biology and crystallization communications. 63(Pt 12):1073-6 [PMID] 18084098.
2007
Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II.
Biochemistry. 46(12):3803-13 [PMID] 17330962.
2007
Structure of adeno-associated virus serotype 8, a gene therapy vector.
Journal of virology. 81(22):12260-71 [PMID] 17728238.
2007
Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions.
Journal of virology. 81(15):7833-43 [PMID] 17507473.
2006
Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry.
Journal of virology. 80(18):8961-9 [PMID] 16940508.
2006
Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6.
Journal of virology. 80(18):9093-103 [PMID] 16940521.
2006
Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.
Biochemistry. 45(17):5468-77 [PMID] 16634628.
2006
Host-selected amino acid changes at the sialic acid binding pocket of the parvovirus capsid modulate cell binding affinity and determine virulence.
Journal of virology. 80(3):1563-73 [PMID] 16415031.
2006
Identification of the sialic acid structures recognized by minute virus of mice and the role of binding affinity in virulence adaptation.
The Journal of biological chemistry. 281(35):25670-7 [PMID] 16822863.
2006
Modeling virus self-assembly pathways: avoiding dynamics using geometric constraint decomposition.
Journal of computational biology : a journal of computational molecular cell biology. 13(6):1232-65 [PMID] 16901239.
2006
Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 1):6-9 [PMID] 16511248.
2006
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 1.
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 12):1271-4 [PMID] 17142915.
2006
Proteolytic mapping of the adeno-associated virus capsid.
Molecular therapy : the journal of the American Society of Gene Therapy. 14(6):809-21 [PMID] 17010669.
2006
Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes.
Journal of virology. 80(22):11393-7 [PMID] 16943302.
2006
Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.
Journal of virology. 80(23):11556-70 [PMID] 16971437.
2006
Structure of human salivary alpha-amylase crystallized in a C-centered monoclinic space group.
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 2):88-93 [PMID] 16511271.
2006
Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.
Acta crystallographica. Section D, Biological crystallography. 62(Pt 3):246-52 [PMID] 16510971.
2006
X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 7):618-22 [PMID] 16820676.
2005
Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries.
Biochemistry. 44(6):1768-79 [PMID] 15697202.
2005
Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae.
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 2):228-31 [PMID] 16511002.
2005
Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer.
Biochemistry. 44(30):10046-53 [PMID] 16042381.
2005
p37 Induces tumor invasiveness.
Molecular cancer therapeutics. 4(7):1031-8 [PMID] 16020660.
2005
Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8.
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 6):558-61 [PMID] 16511095.
2005
Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5.
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 10):917-21 [PMID] 16511195.
2005
Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice.
Journal of virology. 79(17):10931-43 [PMID] 16103145.
2005
Structure of adeno-associated virus type 4.
Journal of virology. 79(8):5047-58 [PMID] 15795290.
2004
Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer.
Journal of structural biology. 146(3):291-301 [PMID] 15099571.
2004
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.
Biochemistry. 43(38):12141-51 [PMID] 15379553.
2004
Crystallization and preliminary X-ray crystallographic studies on recombinant rat choline acetyltransferase.
Acta crystallographica. Section D, Biological crystallography. 60(Pt 2):374-5 [PMID] 14747730.
2004
Isolation and characterization of subgenomic DNAs encapsidated in “single” T = 1 isometric particles of Maize streak virus.
Virology. 323(1):164-71 [PMID] 15165828.
2004
Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase.
Journal of structural biology. 146(3):416-24 [PMID] 15099582.
2004
Structural determination of a partially hemihedrally twinned actin crystal.
Acta crystallographica. Section D, Biological crystallography. 60(Pt 6):1040-7 [PMID] 15159563.
2004
Structural insights and functional implications of choline acetyltransferase.
Journal of structural biology. 148(2):226-35 [PMID] 15477102.
2004
Structure of adeno-associated virus serotype 5.
Journal of virology. 78(7):3361-71 [PMID] 15016858.
2003
Combinations of two capsid regions controlling canine host range determine canine transferrin receptor binding by canine and feline parvoviruses.
Journal of virology. 77(18):10099-105 [PMID] 12941920.
2003
Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding.
Journal of virology. 77(12):6995-7006 [PMID] 12768018.
2003
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 4.
Virology. 306(1):1-6 [PMID] 12620791.
2003
Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer.
The Journal of biological chemistry. 278(15):13159-65 [PMID] 12562770.
2003
Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants.
Journal of virology. 77(22):12211-21 [PMID] 14581558.
2003
The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer.
Acta crystallographica. Section D, Biological crystallography. 59(Pt 1):93-104 [PMID] 12499545.
2002
Crystallization and preliminary X-ray analysis of the tumor metastasis factor p37.
Acta crystallographica. Section D, Biological crystallography. 58(Pt 12):2141-4 [PMID] 12454480.
2002
Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase.
Acta crystallographica. Section D, Biological crystallography. 58(Pt 7):1193-4 [PMID] 12077440.
2002
Microviridae, a family divided: isolation, characterization, and genome sequence of phiMH2K, a bacteriophage of the obligate intracellular parasitic bacterium Bdellovibrio bacteriovorus.
Journal of bacteriology. 184(4):1089-94 [PMID] 11807069.
2002
Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution.
The Journal of biological chemistry. 277(23):20999-1006 [PMID] 11932258.
2001
Identification of aleutian mink disease parvovirus capsid sequences mediating antibody-dependent enhancement of infection, virus neutralization, and immune complex formation.
Journal of virology. 75(22):11116-27 [PMID] 11602751.
2001
Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II.
Biochemistry. 40(6):1741-8 [PMID] 11327835.
2001
Structure of the Maize streak virus geminate particle.
Virology. 279(2):471-7 [PMID] 11162803.
2000
A beta-stranded motif drives capsid protein oligomers of the parvovirus minute virus of mice into the nucleus for viral assembly.
Journal of virology. 74(8):3804-14 [PMID] 10729155.
2000
Biochemical and physical characterization of parvovirus minute virus of mice virus-like particles.
Virology. 267(2):299-309 [PMID] 10662625.
2000
Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism.
Journal of virology. 74(18):8635-47 [PMID] 10954565.
1999
Three-dimensional structure of Aleutian mink disease parvovirus: implications for disease pathogenicity.
Journal of virology. 73(8):6882-91 [PMID] 10400786.
1998
Functional implications of the structure of the murine parvovirus, minute virus of mice.
Structure (London, England : 1993). 6(11):1369-81 [PMID] 9817841.
1998
Structural analysis of the Spiroplasma virus, SpV4: implications for evolutionary variation to obtain host diversity among the Microviridae.
Structure (London, England : 1993). 6(2):135-45 [PMID] 9519405.
1997
Expression of Aleutian mink disease parvovirus capsid proteins in defined segments: localization of immunoreactive sites and neutralizing epitopes to specific regions.
Journal of virology. 71(1):705-14 [PMID] 8985402.
1997
Structure determination of minute virus of mice.
Acta crystallographica. Section D, Biological crystallography. 53(Pt 1):93-102 [PMID] 15299974.
1996
Cryo-electron microscopy studies of empty capsids of human parvovirus B19 complexed with its cellular receptor.
Proceedings of the National Academy of Sciences of the United States of America. 93(15):7502-6 [PMID] 8755503.
1996
Structural analysis of a mutation in canine parvovirus which controls antigenicity and host range.
Virology. 225(1):65-71 [PMID] 8918534.

Grants

Jun 2019 – May 2020
3D characterization of AAV variants and their ligand complexes
Role: Principal Investigator
Funding: STRIDEBIO
Jun 2017 – May 2019
OR-DRPD-ROF2017: Elucidate the Underlying Mechanism by which Commensal Bacteria Stimulate Human Norovirus Infection of B cells
Role: Faculty
Funding: UF DSR OPPORTUNITY FUND
May 2017 – Apr 2022
Therapy development for open-angle glaucoma
Role: Project Manager
Funding: MICHIGAN STATE UNIV via NATL INST OF HLTH NEI
Jun 2016 – May 2020
Structure and dynamics of the VP1u infectivity domain of the Parvoviridae
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Jul 2015 – May 2017
3D characterization of AAV variants
Role: Principal Investigator
Funding: ADVERUM BIOTECHNOLOGIES INC
May 2015 – Apr 2020
NEXT GENERATION OF RECOMBINANT AAV SEROTYPE VECTORS FOR GENE THERAPY
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Dec 2014 – Aug 2018
Characterizing the role of AAV VP1u as a determinant of efficient cellular transduction
Role: Principal Investigator
Funding: APPLIED GENETICS TECH CORP
Sep 2014 – Aug 2019
The role of pH and protease activity in AAV viral transduction
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2014 – May 2019
Developing efficient AAV vectors for photoreceptor targeting via the vitreous
Role: Project Manager
Funding: NATL INST OF HLTH NEI
Jan 2014 – Dec 2017
Determinants of AAV tropism
Role: Principal Investigator
Funding: UNIV OF NORTH CAROLINA CHAPEL HILL via NATL INST OF HLTH NHLBI
Aug 2011 – Aug 2017
MPS: BIO: Theory, Algorithms, Software for Predicting Geometric Entropy-driven Virus Assembly using Multiscale Configuration Space Atlasing and Combinatorial Enumeration
Role: Project Manager
Funding: NATL SCIENCE FOU

Contact Details

Phones:
Business:
(352) 294-8393
Emails:
Business:
mckenna@ufl.edu
Addresses:
Business Mailing:
PO Box 100245
GAINESVILLE FL 32610
Business Street:
LG-181 UFBI
GAINESVILLE FL 32611