Jorg Bungert, Ph.D.
Professor; Coordinator BMB MS Program
Department:
MD-BIOCHEM / MOLECULAR BIOL
Business Phone:
(352) 273-8098
Business Email:
jbungert@ufl.edu
Teaching Profile
Courses Taught
2007-2017,2019-2021
BCH7410 Advanced Gene Regulation
2020-2024
BCH6910 Supervised Research
2020-2024
BCH6971 Research for Master’s Thesis
2013-2014,2016-2024
GMS6001 Fundamentals of Biomedical Sciences I
2015-2024
MDU4010 Cell Biology Seminar
2020-2024
BCH6905 Independent Studies in Biochemistry and Molecular Biology
2020-2024
GMS5905 Special Topics in Biomedical Sciences
2019,2021-2024
BCH6415 Advanced Molecular and Cell Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2013,2015-2017,2017-2024,2023-2024
GMS6061 Nuclear Structure and Dynamics
2014-2017
GMS6647 Transcriptional and Translational Control of Cell Growth and Proliferation
2006-2017
GMS6195 Epigenetics Journal Club
2013-2016
GMS6290 Genetics/Genomics Program Graduate Seminar
2007
MEL4003 Cell Biology Seminar
2022-2024
BCH7412 Epigenetics of Human Disease and Development
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-1801-9706
Publications
2021
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response
Nucleic Acids Research.
49(10):5779-5797
[DOI] 10.1093/nar/gkab415.
[PMID] 34048572.
2021
Super-enhancer mediated regulation of adult β-globin gene expression: the role of eRNA and Integrator
Nucleic Acids Research.
49(3):1383-1396
[DOI] 10.1093/nar/gkab002.
[PMID] 33476375.
2020
LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding.
Science advances.
6(8)
[DOI] 10.1126/sciadv.aaw4651.
[PMID] 32128389.
2019
Phase Separation and Transcription Regulation: Are Super-Enhancers and Locus Control Regions Primary Sites of Transcription Complex Assembly?
BioEssays : news and reviews in molecular, cellular and developmental biology.
41(1)
[DOI] 10.1002/bies.201800164.
[PMID] 30500078.
2018
Computational design and experimental characterization of a novel β-common receptor inhibitory peptide.
Peptides.
104:1-6
[DOI] 10.1016/j.peptides.2018.04.001.
[PMID] 29635062.
2018
Functional interrelationship between TFII‐I and E2F transcription factors at specific cell cycle gene loci
Journal of Cellular Biochemistry.
119(1):712-722
[DOI] 10.1002/jcb.26235.
[PMID] 28657656.
2018
Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression.
Molecular and cellular biology.
38(19)
[DOI] 10.1128/MCB.00197-18.
[PMID] 30012865.
2017
Engineered Zinc Finger DNA-Binding Domains: Synthesis, Assessment of DNA-Binding Affinity, and Direct Protein Delivery to Mammalian Cells.
Methods in molecular biology (Clifton, N.J.).
1654:361-375
[DOI] 10.1007/978-1-4939-7231-9_27.
[PMID] 28986805.
2016
Distinct and Overlapping Dnmti Interactions With Multiple Transcription Factors in Erythroid Cells: Evidence for Co-Repressor Functions
Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms.
1859(12):1515-1526
[DOI] 10.1016/j.bbagrm.2016.09.007.
2016
Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.
Nucleic acids research.
44(15):7173-88
[DOI] 10.1093/nar/gkw327.
[PMID] 27141965.
2013
GATA-1 genome-wide occupancy associates with distinct epigenetic profiles in mouse fetal liver erythropoiesis.
Nucleic acids research.
41(9):4938-48
[DOI] 10.1093/nar/gkt167.
[PMID] 23519611.
2012
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.
The Journal of biological chemistry.
287(48):40279-91
[DOI] 10.1074/jbc.M112.349704.
[PMID] 23014989.
2012
Identification of Protein-Interacting Partners of Usf2 in Erythroid Cells
The FASEB's Journal.
26
2012
Neutralizing the function of a β-globin-associated cis-regulatory DNA element using an artificial zinc finger DNA-binding domain.
Proceedings of the National Academy of Sciences of the United States of America.
109(44):17948-53
[DOI] 10.1073/pnas.1207677109.
[PMID] 23074246.
2011
Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.
Blood.
118(5):1386-94
[DOI] 10.1182/blood-2010-11-319111.
[PMID] 21653943.
2011
Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart.
Molecular and cellular biology.
31(22):4633-45
[DOI] 10.1128/MCB.05940-11.
[PMID] 21930795.
2011
Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes.
Journal of cellular and molecular medicine.
15(9):1963-72
[DOI] 10.1111/j.1582-4934.2010.01193.x.
[PMID] 21029371.
2011
Role of helix-loop-helix proteins during differentiation of erythroid cells.
Molecular and cellular biology.
31(7):1332-43
[DOI] 10.1128/MCB.01186-10.
[PMID] 21282467.
2010
Dot(1L) on the spot.
Blood.
116(22):4385-6
[DOI] 10.1182/blood-2010-09-305326.
[PMID] 21109620.
2010
H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation.
Blood.
115(10):2028-37
[DOI] 10.1182/blood-2009-07-236059.
[PMID] 20068219.
2010
Induction of nitric oxide by erythropoietin is mediated by the {beta} common receptor and requires interaction with VEGF receptor 2.
Blood.
115(4):896-905
[DOI] 10.1182/blood-2009-04-216432.
[PMID] 19965681.
2010
Intrinsic and extrinsic effects of mafG deficiency on hematopoietic recovery following bone marrow transplant.
Experimental hematology.
38(12):1251-60
[DOI] 10.1016/j.exphem.2010.08.005.
[PMID] 20813153.
2010
Regulation of Hdac1 Histone Deacetylase Activity During Hematopoesis
Blood.
116:1581-1582
2010
USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus.
The Journal of biological chemistry.
285(21):15894-905
[DOI] 10.1074/jbc.M109.098376.
[PMID] 20236933.
2009
Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells.
The Journal of biological chemistry.
284(30):20130-5
[DOI] 10.1074/jbc.M109.001461.
[PMID] 19491096.
2009
Defective erythropoiesis in transgenic mice expressing dominant-negative upstream stimulatory factor.
Molecular and cellular biology.
29(21):5900-10
[DOI] 10.1128/MCB.00419-09.
[PMID] 19704006.
2009
Gata4 Regulates Expression of the Erythropoietin Receptor in Cardiomyocytes.
Blood.
114
2009
Maneuver At the Transcription Start Site
Epigenetics.
4:1-4
2009
Nkx2-5-Dependent Transcriptional Regulation of Anf and Bnp Through a Common Distal Enhancer
Circulation.
120
2009
The Role of Hdac1 Acetylation in Hematopoiesis and Gata-1 Function.
Blood.
114
2009
Trans-regulation of histone deacetylase activities through acetylation.
The Journal of biological chemistry.
284(50):34901-10
[DOI] 10.1074/jbc.M109.038356.
[PMID] 19822520.
2009
Transcriptional Regulation By Tal1 a Link Between Epigenetic Modifications and Erythropoiesis
Epigenetics.
4:257-261
2009
Transgenic mice expressing small interfering RNA against Gata4 point to a crucial role of Gata4 in the heart and gonads.
Journal of molecular endocrinology.
43(4):157-69
[DOI] 10.1677/JME-09-0030.
[PMID] 19491195.
2008
Assembly and structural analysis of a covalently closed nano-scale DNA cage.
Nucleic acids research.
36(4):1113-9
[PMID] 18096620.
2008
Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.
Molecular and cellular biology.
28(5):1584-95
[PMID] 18086895.
2008
Locus control region mediated regulation of adult beta-globin gene expression.
Journal of cellular biochemistry.
105(1):9-16
[DOI] 10.1002/jcb.21820.
[PMID] 18500726.
2008
Regulation of Chromatin Looping and Transcription By Prmt1 Mediated H4R3 Methylation
Blood.
112
2002
Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis.
British journal of haematology.
119(2):510-5
[PMID] 12406094.
1999
Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.
Molecular and cellular biology.
19(4):3062-72
[PMID] 10082573.
Grants
Jan 2024
ACTIVE
The molecular basis of 7SK RNA methylation in non-small cell lung cancer
Role: Co-Investigator
Funding: NATL INST OF HLTH NCI
Mar 2020
– Aug 2022
Structure and Function of the human beta globin locus control region
Role: Principal Investigator
Funding: AMER SOC OF HEMATOLOGY
Jan 2019
– Feb 2020
Epigenetic regulation of hematopoiesis
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2018
– Jun 2020
Functional proteomic and genomic analysis of transcription factor TFII-I in erythroid cells
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jun 2018
– May 2020
The Role of Long Noncoding RNA in Hematopoiesis
Role: Principal Investigator
Funding: PENNSYLVANIA STATE UNIV
via NATL INST OF HLTH NIDDK
Jun 2018
– May 2022
OR-DRPD-ROF2018: Development of in vivo targeted delivery and detection methods for potentially therapeutic synthetic DNA-binding proteins
Role: Principal Investigator
Funding: UF RESEARCH
Jan 2015
ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Sep 2014
– Aug 2019
Structure and function of the human beta-globin locus control region
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2010
– Apr 2016
Functional Protemomics in differentiating erythroid cell
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Contact Details
Phones:
- Business:
- (352) 273-8098
Emails:
- Business:
- jbungert@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100245
GAINESVILLE FL 32610 - Business Street:
-
392A CANCER GENETICS RESEARCH COMPLEX
GAINESVILLE FL 326110001