Robert J Cousins

Robert J Cousins,

Eminent Scholar, Boston Family Professor,  and Director Of The Center For Nutritional Studies

Department: Food Science & Human Nutrition
Business Phone: (352) 294-3700
Business Email: cousins@ufl.edu

Teaching Profile

Courses Taught
2006,2008-2010,2010-2014,2012-2020,2014-2020,2016-2020,2020
HUN6812C Analytical Techniques in Nutritional Biochemistry
2007,2009-2011,2011-2015,2013-2019,2015-2021,2017-2021,2019-2021,2021
HUN6356 Minerals in Nutrition

Research Profile

Dr. Cousins’ research has evolved from understanding the nutritional significance of zinc to elucidating how this micronutrient acts as a signaling molecule through regulated cellular transporters to produce influences on cellular function, host defense mechanisms and specific diseases. The laboratory members work as a team but on individual projects built around the central theme of zinc metabolism and function using the latest available technologies. The laboratory is unique in that this experimental theme is maintained from experiments at the molecular level, to those with isolated cells, with mutant mouse models, and to those with human subjects.

Publications

2020
Deletion of metal transporter Zip14 (Slc39a14) produces skeletal muscle wasting, endotoxemia, Mef2c activation and induction of miR-675 and Hspb7.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-61059-2. [PMID] 32132660.
2020
Intestine-specific deletion of metal transporter Zip14 (Slc39a14) causes brain manganese overload and locomotor defects of manganism.
American journal of physiology. Gastrointestinal and liver physiology. 318(4):G673-G681 [DOI] 10.1152/ajpgi.00301.2019. [PMID] 32003605.
2020
Mechanism of Manganese Dysregulation of Dopamine Neuronal Activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(30):5871-5891 [DOI] 10.1523/JNEUROSCI.2830-19.2020. [PMID] 32576620.
2018
Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis.
PLoS genetics. 14(4) [DOI] 10.1371/journal.pgen.1007321. [PMID] 29621230.
2018
The Multiple Faces of the Metal Transporter ZIP14 (SLC39A14).
The Journal of nutrition. 148(2):174-184 [DOI] 10.1093/jn/nxx041. [PMID] 29490098.
2017
Hepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress.
Proceedings of the National Academy of Sciences of the United States of America. 114(29):E5805-E5814 [DOI] 10.1073/pnas.1704012114. [PMID] 28673968.
2017
Metal Transporter Zip14 (Slc39a14) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(25):5996-6006 [DOI] 10.1523/JNEUROSCI.0285-17.2017. [PMID] 28536273.
2016
Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion.
Experimental gerontology. 85:88-94 [DOI] 10.1016/j.exger.2016.09.013. [PMID] 27647172.
2016
Dietary Zinc Regulates Apoptosis through the Phosphorylated Eukaryotic Initiation Factor 2α/Activating Transcription Factor-4/C/EBP-Homologous Protein Pathway during Pharmacologically Induced Endoplasmic Reticulum Stress in Livers of Mice.
The Journal of nutrition. 146(11):2180-2186 [PMID] 27605406.
2016
Driving Along the Zinc Road.
Annual review of nutrition. 36:1-15 [DOI] 10.1146/annurev-nutr-071715-050854. [PMID] 27090747.
2016
Effect of A One-Week Balanced Diet on Expression of Genes Related to Zinc Metabolism and Inflammation in Type 2 Diabetic Patients.
Clinical nutrition research. 5(1):26-32 [DOI] 10.7762/cnr.2016.5.1.26. [PMID] 26839874.
2016
Hepatic ZIP14-mediated Zinc Transport Contributes to Endosomal Insulin Receptor Trafficking and Glucose Metabolism.
The Journal of biological chemistry. 291(46):23939-23951 [PMID] 27703010.
2016
Zinc transporter Slc39a14 regulates inflammatory signaling associated with hypertrophic adiposity.
American journal of physiology. Endocrinology and metabolism. 310(4):E258-68 [DOI] 10.1152/ajpendo.00421.2015. [PMID] 26646099.
2015
Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function.
American journal of physiology. Gastrointestinal and liver physiology. 308(3):G171-8 [DOI] 10.1152/ajpgi.00021.2014. [PMID] 25428902.
2015
Zinc dyshomeostasis during polymicrobial sepsis in mice involves zinc transporter Zip14 and can be overcome by zinc supplementation.
American journal of physiology. Gastrointestinal and liver physiology. 309(9):G768-78 [DOI] 10.1152/ajpgi.00179.2015. [PMID] 26272258.
2013
Characterization and Distribution of the Zinc Transporter, Zip14, Along the Murine Gi Tract
The FASEB's Journal. 27
2013
Evidence for associated production of a single top quark and W boson in pp collisions at sqrt[s]=7  TeV.
Physical review letters. 110(2) [PMID] 23383893.
2013
Gastric and colonic zinc transporter ZIP11 (Slc39a11) in mice responds to dietary zinc and exhibits nuclear localization.
The Journal of nutrition. 143(12):1882-8 [DOI] 10.3945/jn.113.184457. [PMID] 24089422.
2013
Inclusive search for supersymmetry using razor variables in pp collisions at √s=7 TeV.
Physical review letters. 111(8) [PMID] 24010428.
2013
Measurement of associated production of vector bosons and top quark-antiquark pairs in pp collisions at sqrt[s]=7  TeV.
Physical review letters. 110(17) [PMID] 23679709.
2013
Measurement of the Υ1S, Υ2S, and Υ3S polarizations in pp collisions at sqrt[s] = 7 TeV.
Physical review letters. 110(8) [PMID] 23473130.
2013
Search for pair production of third-generation leptoquarks and top squarks in pp collisions at sqrt[s] = 7 TeV.
Physical review letters. 110(8) [PMID] 23473129.
2013
Searches for new physics using the tt¯ invariant mass distribution in pp collisions at √s=8 TeV.
Physical review letters. 111(21) [PMID] 24313480.
2013
Study of the mass and spin-parity of the Higgs boson candidate via its decays to Z boson pairs.
Physical review letters. 110(8) [PMID] 23473131.
2012
Azimuthal anisotropy of charged particles at high transverse momenta in Pb-Pb collisions at sqrt[s(NN)] = 2.76  TeV.
Physical review letters. 109(2) [PMID] 23030154.
2012
Characterization and Regulation of the Novel Zinc Transporter, Zip11, in the Murine Gastrointestinal Tract
The FASEB's Journal. 26
2012
Measurement of the electron charge asymmetry in inclusive W production in pp collisions at sqrt[s]=7  TeV.
Physical review letters. 109(11) [PMID] 23005617.
2012
Measurement of the pseudorapidity and centrality dependence of the transverse energy density in Pb-Pb collisions at √(s(NN))=2.76 TeV.
Physical review letters. 109(15) [PMID] 23102301.
2012
Observation of a new Ξb baryon.
Physical review letters. 108(25) [PMID] 23004588.
2012
Observation of sequential Υ suppression in PbPb collisions.
Physical review letters. 109(22) [PMID] 23368113.
2012
Proteomic analysis shows the upregulation of erythrocyte dematin in zinc-restricted human subjects.
The American journal of clinical nutrition. 95(5):1096-102 [DOI] 10.3945/ajcn.111.032862. [PMID] 22456662.
2012
Search for a light pseudoscalar Higgs boson in the dimuon decay channel in pp collisions at √s = 7 TeV.
Physical review letters. 109(12) [PMID] 23005937.
2012
Search for a W’ or techni-ρ decaying into WZ in pp Collisions at sqrt[s] = 7  TeV.
Physical review letters. 109(14) [PMID] 23083236.
2012
Search for dark matter and large extra dimensions in pp collisions yielding a photon and missing transverse energy.
Physical review letters. 108(26) [PMID] 23004964.
2012
Search for heavy neutrinos and W(R) bosons with right-handed couplings in a left-right symmetric model in pp collisions at sqrt[s]=7  TeV.
Physical review letters. 109(26) [PMID] 23368549.
2012
Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at √s = 7 TeV.
Physical review letters. 109(17) [PMID] 23215177.
2012
Search for new physics with same-sign isolated dilepton events with jets and missing transverse energy.
Physical review letters. 109(7) [PMID] 23006358.
2012
Search for signatures of extra dimensions in the diphoton mass spectrum at the large hadron collider.
Physical review letters. 108(11) [PMID] 22540461.
2012
Search for the standard model Higgs boson in the decay channel H→ZZ→4ℓ in pp collisions at √s=7 TeV.
Physical review letters. 108(11) [PMID] 22540464.
2012
Study of the Dijet mass spectrum in pp → W+jets events at sqrt[s] = 7 TeV.
Physical review letters. 109(25) [PMID] 23368450.
2012
The zinc transporter Zip14 influences c-Met phosphorylation and hepatocyte proliferation during liver regeneration in mice.
Gastroenterology. 142(7):1536-46.e5 [DOI] 10.1053/j.gastro.2012.02.046. [PMID] 22374166.
2012
Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia).
PloS one. 7(10) [DOI] 10.1371/journal.pone.0048679. [PMID] 23110240.
2012
Zip14 Regulates Tight Junction Protein Expression in Response To Lps
The FASEB's Journal. 26
2011
Dijet azimuthal decorrelations in pp collisions at √s=7 TeV.
Physical review letters. 106(12) [PMID] 21517306.
2011
Genomic analysis, cytokine expression, and microRNA profiling reveal biomarkers of human dietary zinc depletion and homeostasis.
Proceedings of the National Academy of Sciences of the United States of America. 108(52):20970-5 [DOI] 10.1073/pnas.1117207108. [PMID] 22171008.
2011
Indications of suppression of excited Υ states in Pb-Pb collisions at √(s(NN))=2.76 TeV.
Physical review letters. 107(5) [PMID] 21867063.
2011
Measurement of dijet angular distributions and search for quark compositeness in pp collisions at √s = 7 TeV.
Physical review letters. 106(20) [PMID] 21668222.
2011
Measurement of the B(+) production cross section in pp collisions at sqrt[s]=7  TeV.
Physical review letters. 106(11) [PMID] 21469857.
2011
Measurement of the B0 production cross section in pp collisions at sqrt[s] = 7 TeV.
Physical review letters. 106(25) [PMID] 21770632.
2011
Measurement of the inclusive jet cross section in pp collisions at √s = 7 TeV.
Physical review letters. 107(13) [PMID] 22026843.
2011
Measurement of the isolated prompt photon production cross section in pp collisions at √s=7  TeV.
Physical review letters. 106(8) [PMID] 21405566.
2011
Measurement of the polarization of W bosons with large transverse momenta in W + jets events at the LHC.
Physical review letters. 107(2) [PMID] 21797595.
2011
Measurement of the t-channel single top quark production cross section in pp collisions at √s=7  TeV.
Physical review letters. 107(9) [PMID] 21929225.
2011
MTF-1-mediated repression of the zinc transporter Zip10 is alleviated by zinc restriction.
PloS one. 6(6) [DOI] 10.1371/journal.pone.0021526. [PMID] 21738690.
2011
Search for a vectorlike quark with charge 2/3 in t+Z events from pp collisions at √s=7 TeV.
Physical review letters. 107(27) [PMID] 22243304.
2011
Search for B(s)(0) → μ+ μ- and B(0) → μ+ μ- decays in pp collisions at sqrt[s] = 7 TeV.
Physical review letters. 107(19) [PMID] 22181597.
2011
Search for neutral minimal supersymmetric standard model Higgs bosons decaying to tau pairs in pp collisions at √s=7 TeV.
Physical review letters. 106(23) [PMID] 21770497.
2011
Search for new physics with a monojet and missing transverse energy in pp collisions at √s = 7 TeV.
Physical review letters. 107(20) [PMID] 22181725.
2011
Search for pair production of first-generation scalar leptoquarks in pp collisions at √s = 7 TeV.
Physical review letters. 106(20) [PMID] 21668220.
2011
Search for pair production of second-generation scalar leptoquarks in pp collisions at √s = 7 TeV.
Physical review letters. 106(20) [PMID] 21668221.
2011
Search for stopped Gluinos in pp collisions at square root s=7 TeV.
Physical review letters. 106(1) [PMID] 21231732.
2011
Search for supersymmetry at the LHC in events with jets and missing transverse energy.
Physical review letters. 107(22) [PMID] 22182023.
2011
Search for supersymmetry in pp collisions at √7 TeV in events with two photons and missing transverse energy.
Physical review letters. 106(21) [PMID] 21699288.
2011
Search for three-jet resonances in pp collisions at square root(s)=7  TeV.
Physical review letters. 107(10) [PMID] 21981492.
2011
Study of Z Boson Production in PbPb Collisions at √S(NN)=2.76 TeV.
Physical review letters. 106(21) [PMID] 21699291.
2011
Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron.
American journal of physiology. Cell physiology. 301(4):C862-71 [DOI] 10.1152/ajpcell.00479.2010. [PMID] 21653899.
2010
First measurement of Bose-Einstein correlations in proton-proton collisions at √s=0.9 and 2.36 TeV at the LHC.
Physical review letters. 105(3) [PMID] 20867758.
2010
Gastrointestinal factors influencing zinc absorption and homeostasis.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 80(4-5):243-8 [DOI] 10.1024/0300-9831/a000030. [PMID] 21462106.
2010
Plenary Lecture 2: Transcription factors, regulatory elements and nutrient-gene communication.
The Proceedings of the Nutrition Society. 69(1):91-4 [DOI] 10.1017/S0029665109991790. [PMID] 19968906.
2010
Search for dijet resonances in 7 TeV pp collisions at CMS.
Physical review letters. 105(21) [PMID] 21231289.
2010
Search for quark compositeness with the dijet centrality ratio in pp collisions at √s=7 TeV.
Physical review letters. 105(26) [PMID] 21231646.
2010
STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells.
Proceedings of the National Academy of Sciences of the United States of America. 107(7):2818-23 [DOI] 10.1073/pnas.0914941107. [PMID] 20133611.
2010
Transverse-momentum and pseudorapidity distributions of charged hadrons in pp collisions at square root of s = 7 TeV.
Physical review letters. 105(2) [PMID] 20867699.
2009
Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes.
American journal of physiology. Gastrointestinal and liver physiology. 296(4):G860-7 [DOI] 10.1152/ajpgi.90676.2008. [PMID] 19179618.
2009
Krüppel-like factor 4 regulates adaptive expression of the zinc transporter Zip4 in mouse small intestine.
American journal of physiology. Gastrointestinal and liver physiology. 296(3):G517-23 [DOI] 10.1152/ajpgi.90568.2008. [PMID] 19147802.
2009
Mammalian zinc transporters: nutritional and physiologic regulation.
Annual review of nutrition. 29:153-76 [DOI] 10.1146/annurev-nutr-033009-083312. [PMID] 19400752.
2009
Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-gamma expression in activated human T cells.
Journal of leukocyte biology. 86(2):337-48 [DOI] 10.1189/jlb.1208759. [PMID] 19401385.
2008
Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency.
The Journal of nutrition. 138(11):2076-83 [DOI] 10.3945/jn.108.093575. [PMID] 18936201.
2007
Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression.
Proceedings of the National Academy of Sciences of the United States of America. 104(47):18636-41 [PMID] 18003899.
2006
Mammalian zinc transport, trafficking, and signals.
The Journal of biological chemistry. 281(34):24085-9 [PMID] 16793761.
2006
Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations.
Proceedings of the National Academy of Sciences of the United States of America. 103(6):1699-704 [PMID] 16434472.
2006
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.
Proceedings of the National Academy of Sciences of the United States of America. 103(37):13612-7 [PMID] 16950869.
2005
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response.
Proceedings of the National Academy of Sciences of the United States of America. 102(19):6843-8 [PMID] 15863613.
2004
Mammalian zinc transporters.
Annual review of nutrition. 24:151-72 [PMID] 15189117.
2004
Responsive transporter genes within the murine intestinal-pancreatic axis form a basis of zinc homeostasis.
Proceedings of the National Academy of Sciences of the United States of America. 101(40):14355-60 [PMID] 15381762.
2003
A global view of the selectivity of zinc deprivation and excess on genes expressed in human THP-1 mononuclear cells.
Proceedings of the National Academy of Sciences of the United States of America. 100(12):6952-7 [PMID] 12756304.
2003
Dietary zinc modulates gene expression in murine thymus: results from a comprehensive differential display screening.
Proceedings of the National Academy of Sciences of the United States of America. 100(7):3883-8 [PMID] 12646709.
2003
Regulation of zinc metabolism and genomic outcomes.
The Journal of nutrition. 133(5 Suppl 1):1521S-6S [DOI] 10.1093/jn/133.5.1521S. [PMID] 12730457.
2003
The permissive effect of zinc deficiency on uroguanylin and inducible nitric oxide synthase gene upregulation in rat intestine induced by interleukin 1alpha is rapidly reversed by zinc repletion.
The Journal of nutrition. 133(1):51-6 [PMID] 12514266.
2003
Zinc transporters 1, 2 and 4 are differentially expressed and localized in rats during pregnancy and lactation.
The Journal of nutrition. 133(2):342-51 [PMID] 12566465.
2002
Overexpression of CRIP in transgenic mice alters cytokine patterns and the immune response.
American journal of physiology. Endocrinology and metabolism. 282(6):E1197-203 [PMID] 12006348.
2001
cDNA array analysis identifies thymic LCK as upregulated in moderate murine zinc deficiency before T-lymphocyte population changes.
The Journal of nutrition. 131(12):3189-96 [PMID] 11739864.
2001
Dietary zinc deficiency increases uroguanylin accumulation in rat kidney.
Kidney international. 59(4):1424-31 [PMID] 11260404.
2001
Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats.
The Journal of nutrition. 131(1):46-52 [PMID] 11208937.
2001
Effects of intracellular zinc depletion on metallothionein and ZIP2 transporter expression and apoptosis.
Journal of leukocyte biology. 70(4):559-66 [PMID] 11590192.
2001
Metallothionein expression protects against carbon tetrachloride-induced hepatotoxicity, but overexpression and dietary zinc supplementation provide no further protection in metallothionein transgenic and knockout mice.
The Journal of nutrition. 131(2):215-22 [PMID] 11160536.
2001
Modulation of intestinal gene expression by dietary zinc status: effectiveness of cDNA arrays for expression profiling of a single nutrient deficiency.
Proceedings of the National Academy of Sciences of the United States of America. 98(24):13507-13 [PMID] 11717422.
2000
Integrative aspects of zinc transporters.
The Journal of nutrition. 130(5S Suppl):1384S-7S [DOI] 10.1093/jn/130.5.1384S. [PMID] 10801948.
2000
Introduction.
The Journal of nutrition. 130(5 Suppl):1341S-3S [DOI] 10.1093/jn/130.5.1341S. [PMID] 10801940.
2000
L-type Ca(2+) channel-mediated Zn(2+) toxicity and modulation by ZnT-1 in PC12 cells.
Brain research. 886(1-2):99-107 [PMID] 11119691.
2000
Metallothionein expression in animals: a physiological perspective on function.
The Journal of nutrition. 130(5):1085-8 [PMID] 10801901.
2000
Metallothionein mRNA in monocytes and peripheral blood mononuclear cells and in cells from dried blood spots increases after zinc supplementation of men.
The Journal of nutrition. 130(9):2180-7 [PMID] 10958810.
2000
Prouroguanylin overproduction and localization in the intestine of zinc-deficient rats.
The Journal of nutrition. 130(11):2726-32 [PMID] 11053513.
2000
Regulation of cysteine-rich intestinal protein, a zinc finger protein, by mediators of the immune response.
The Journal of infectious diseases. 182 Suppl 1:S81-4 [PMID] 10944488.
2000
Regulation of intestinal gene expression by dietary zinc: induction of uroguanylin mRNA by zinc deficiency.
The Journal of nutrition. 130(5S Suppl):1393S-8S [DOI] 10.1093/jn/130.5.1393S. [PMID] 10801950.
1999
Nutritional regulation of gene expression.
The American journal of medicine. 106(1A):20S-23S; discussion 50S [PMID] 10089110.
1998
A role of zinc in the regulation of gene expression.
The Proceedings of the Nutrition Society. 57(2):307-11 [PMID] 9656334.
1998
Mammalian zinc transporters.
The Journal of nutrition. 128(4):667-70 [PMID] 9521625.
1998
Metallothionein expression is increased in monocytes and erythrocytes of young men during zinc supplementation.
The Journal of nutrition. 128(4):707-13 [PMID] 9521632.
1998
Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression.
The Journal of nutrition. 128(5):825-31 [PMID] 9566988.
1998
Regulation of the zinc transporter ZnT-1 by dietary zinc.
Proceedings of the National Academy of Sciences of the United States of America. 95(9):4841-6 [PMID] 9560190.
1998
Structural characterization of the rat cysteine-rich intestinal protein gene and overexpression of this LIM-only protein in transgenic mice.
DNA and cell biology. 17(12):1057-64 [PMID] 9881673.
1998
The effects of serum from patients with acute liver failure on the growth and metabolism of Hep G2 cells.
Artificial organs. 22(12):1023-30 [PMID] 9876094.
1997
Competitive reverse transcriptase-polymerase chain reaction shows that dietary zinc supplementation in humans increases monocyte metallothionein mRNA levels.
The Journal of nutrition. 127(5):694-8 [PMID] 9164988.
1997
Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells.
Protein expression and purification. 9(3):379-87 [PMID] 9126610.
1997
Immunohistochemical localization of cysteine-rich intestinal protein in rat small intestine.
The American journal of physiology. 272(4 Pt 1):G751-9 [PMID] 9142905.
1997
Upregulation of rat intestinal uroguanylin mRNA by dietary zinc restriction.
The American journal of physiology. 272(5 Pt 1):G972-8 [PMID] 9176203.
1996
Apolipoprotein B mRNA editing is preserved in the intestine and liver of zinc-deficient rats.
The Journal of nutrition. 126(4):860-4 [PMID] 8613888.
1996
Differential display of intestinal mRNAs regulated by dietary zinc.
Proceedings of the National Academy of Sciences of the United States of America. 93(14):6863-8 [PMID] 8692909.
1996
Differential expression of cysteine-rich intestinal protein in liver and intestine in CCl4-induced inflammation.
The American journal of physiology. 270(4 Pt 1):G613-8 [PMID] 8928791.
1996
Interaction of different organic and inorganic zinc and copper sources fed to rats.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 10(3):139-44 [PMID] 8905556.
1996
James Smith Dinning (1922-1991).
The Journal of nutrition. 126(10):2461-5 [PMID] 8857505.
1996
Lipopolysaccharide regulates cysteine-rich intestinal protein, a zinc-finger protein, in immune cells and plasma.
Journal of leukocyte biology. 59(2):172-7 [PMID] 8603989.
1996
The effect of oxygen concentration on the function of human Hep G2 hepatoma cells and primary cultures of rat hepatocytes.
Biochemical Society transactions. 24(2) [PMID] 8736876.
1995
Relative bioavailability of two organic and two inorganic zinc sources fed to sheep.
Journal of animal science. 73(4):1202-7 [PMID] 7628965.
1995
Zinc status is not adversely affected by folic acid supplementation and zinc intake does not impair folate utilization in human subjects.
The Journal of nutrition. 125(1):66-72 [PMID] 7815178.
1994
Cloning and initial characterization of the promoter region of the rat cysteine-rich intestinal protein gene.
The Biochemical journal. 303 ( Pt 3)(Pt 3):731-6 [PMID] 7980439.
1994
Expression of cysteine-rich intestinal protein in rat intestine and transfected cells is not zinc dependent.
The Journal of nutrition. 124(1):13-7 [PMID] 8283289.
1994
Metal elements and gene expression.
Annual review of nutrition. 14:449-69 [PMID] 7946529.
1994
Purification and properties of rat cysteine-rich intestinal protein.
The Biochemical journal. 299 ( Pt 2)(Pt 2):445-50 [PMID] 8172605.
1993
Cloning of rat intestinal mRNAs affected by zinc deficiency.
The Journal of nutrition. 123(1):35-41 [PMID] 8421228.
1993
Malabsorption of zinc in rats with acetic acid-induced enteritis and colitis.
The Journal of nutrition. 123(8):1389-95 [PMID] 8336209.
1993
Metallothionein expression in rat bone marrow is dependent on dietary zinc but not dependent on interleukin-1 or interleukin-6.
The Journal of nutrition. 123(4):642-8 [PMID] 8463865.
1993
Regulation of cysteine-rich intestinal protein by dexamethasone in the neonatal rat.
Proceedings of the National Academy of Sciences of the United States of America. 90(2):712-5 [PMID] 8421709.
1993
Zinc metabolism and metallothionein expression in bone marrow during erythropoiesis.
The American journal of physiology. 264(5 Pt 1):E770-5 [PMID] 8498498.
1992
Altered zinc metabolism occurs in murine lethal milk syndrome.
The Journal of nutrition. 122(11):2233-8 [PMID] 1432264.
1992
Cysteine-rich intestinal protein and intestinal metallothionein: an inverse relationship as a conceptual model for zinc absorption in rats.
The Journal of nutrition. 122(1):89-95 [PMID] 1729476.
1992
Erythrocyte metallothionein response to dietary zinc in humans.
The Journal of nutrition. 122(12):2408-14 [PMID] 1453226.
1992
Mechanisms of caeruloplasmin biosynthesis in normal and copper-deficient rats.
The Biochemical journal. 282 ( Pt 3)(Pt 3):835-9 [PMID] 1554368.
1992
Nuclear zinc uptake and interactions and metallothionein gene expression are influenced by dietary zinc in rats.
The Journal of nutrition. 122(1):56-64 [PMID] 1370327.
1992
Treatment of Wilson’s disease with zinc: X. Intestinal metallothionein induction.
The Journal of laboratory and clinical medicine. 120(3):380-6 [PMID] 1517684.
1991
Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport.
Proceedings of the National Academy of Sciences of the United States of America. 88(21):9671-4 [PMID] 1946385.
1991
Intestinal metallothionein gene expression and zinc absorption in rats are zinc-responsive but refractory to dexamethasone and interleukin 1 alpha.
The Journal of nutrition. 121(9):1389-96 [PMID] 1880617.
1991
Maintenance of zinc-dependent hepatic functions in rat hepatocytes cultured in medium without added zinc.
The Journal of nutrition. 121(6):844-53 [PMID] 2033469.
1991
Measurement of human metallothionein by enzyme-linked immunosorbent assay.
Methods in enzymology. 205:131-40 [PMID] 1779776.
1991
Metallothionein and zinc metabolism in hepatocytes.
Methods in enzymology. 205:575-84 [PMID] 1779820.
1990
Erythrocyte metallothionein as an index of zinc status in humans.
Proceedings of the National Academy of Sciences of the United States of America. 87(4):1259-62 [PMID] 2304897.
1990
Interleukin 6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures.
Proceedings of the National Academy of Sciences of the United States of America. 87(8):3137-41 [PMID] 2326272.
1989
Effect of EDTA and zinc-methionine complex on zinc absorption by rat intestine.
The Journal of nutrition. 119(8):1179-87 [PMID] 2506318.
1989
Enzyme-linked immunosorbent assay for human metallothionein: correlation of induction with infection.
The Journal of laboratory and clinical medicine. 113(2):221-8 [PMID] 2915186.
1989
Kinetics of zinc metabolism in the rat: effect of dibutyryl cAMP.
The American journal of physiology. 256(3 Pt 1):E420-30 [PMID] 2538073.
1989
Theoretical and practical aspects of zinc uptake and absorption.
Advances in experimental medicine and biology. 249:3-12 [PMID] 2658491.
1989
Zinc uptake by basolateral membrane vesicles from rat small intestine.
The Journal of nutrition. 119(4):639-46 [PMID] 2539449.
1988
An enzyme-linked immunoadsorbent assay for rat ceruloplasmin.
Biological trace element research. 17:1-9 [PMID] 2484349.
1988
Interleukin-1–stimulated induction of ceruloplasmin synthesis in normal and copper-deficient rats.
The Journal of nutrition. 118(3):375-81 [PMID] 3258371.
1988
Maternal zinc deprivation and interleukin-1 influence metallothionein gene expression and zinc metabolism of rats.
The Journal of nutrition. 118(12):1570-6 [PMID] 3264852.
1988
Metallothionein gene expression in rats: tissue-specific regulation by dietary copper and zinc.
The Journal of nutrition. 118(2):222-8 [PMID] 3339479.
1988
Relationship of 65Zn absorption kinetics to intestinal metallothionein in rats: effects of zinc depletion and fasting.
The Journal of nutrition. 118(4):497-502 [PMID] 3357065.
1988
Tissue-specific regulation of zinc metabolism and metallothionein genes by interleukin 1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2(13):2884-90 [PMID] 2458983.
1988
Zinc suppression of free radicals induced in cultures of rat hepatocytes by iron, t-butyl hydroperoxide, and 3-methylindole.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 189(1):100-9 [PMID] 2847178.
1987
Induction of ceruloplasmin synthesis by retinoic acid in rats: influence of dietary copper and vitamin A status.
The Journal of nutrition. 117(9):1615-22 [PMID] 3655940.
1987
Kinetic analysis of zinc uptake and serosal transfer by vascularly perfused rat intestine.
The American journal of physiology. 252(6 Pt 1):G825-31 [PMID] 3591948.
1987
Metallothionein.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 185(2):107-19 [PMID] 3554258.
1987
Portal copper transport in rats by albumin.
The American journal of physiology. 252(3 Pt 1):E327-33 [PMID] 3826360.
1987
Regulation of liver zinc metabolism and metallothionein by cAMP, glucagon and glucocorticoids and suppression of free radicals by zinc.
Experientia. Supplementum. 52:545-53 [PMID] 2822465.
1986
Coordinate regulation of zinc metabolism and metallothionein gene expression in rats.
The American journal of physiology. 251(6 Pt 1):E688-94 [PMID] 3024499.
1986
Influence of dietary zinc deficiency and parenteral zinc on rat liver fructose 1,6-bisphosphatase activity.
Biochemical and biophysical research communications. 134(2):944-50 [PMID] 3004476.
1986
Kinetics of zinc uptake and exchange by primary cultures of rat hepatocytes.
The American journal of physiology. 250(6 Pt 1):E677-85 [PMID] 3087217.
1986
Toward a molecular understanding of zinc metabolism.
Clinical physiology and biochemistry. 4(1):20-30 [PMID] 2420502.
1986
Zinc uptake and metabolism by hepatocytes.
Federation proceedings. 45(12):2805-9 [PMID] 3533646.
1985
Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin.
Physiological reviews. 65(2):238-309 [PMID] 3885271.
1985
Ceruloplasmin and metallothionein induction by zinc and 13-cis-retinoic acid in rats with adjuvant inflammation.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 179(2):168-72 [PMID] 3857634.
1985
Copper and zinc absorption in the rat: mechanism of mutual antagonism.
The Journal of nutrition. 115(2):159-66 [PMID] 3968585.
1985
Effects of dietary zinc depletion and food restriction on intestinal transport of cadmium in the rat.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 180(2):296-302 [PMID] 4048167.
1985
Kinetics of zinc absorption by luminally and vascularly perfused rat intestine.
The American journal of physiology. 248(1 Pt 1):G46-53 [PMID] 3966560.
1984
Augmentation of dexamethasone induction of rat liver metallothionein by zinc.
The Biochemical journal. 219(3):959-63 [PMID] 6743254.
1984
Changes in rat liver metallothionein and metallothionein mRNA induced by isopropanol.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 175(4):522-9 [PMID] 6143322.
1984
Glucocorticoid independent mediation of interleukin-1 induced changes in serum zinc and liver metallothionein levels.
Life sciences. 35(21):2113-8 [PMID] 6333572.
1984
Mediation of endotoxin-induced changes in zinc metabolism in rats.
The American journal of physiology. 247(4 Pt 1):E436-41 [PMID] 6388345.
1983
Differential regulation of copper and zinc metabolism in rat liver parenchymal cells in primary cultures.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 173(4):486-94 [PMID] 6889313.
1983
Effect of citrate, glutathione and picolinate on zinc transport by brush border membrane vesicles from rat intestine.
The Journal of nutrition. 113(8):1653-6 [PMID] 6875697.
1983
Hyperglycemic action of zinc in rats.
The Journal of nutrition. 113(8):1657-63 [PMID] 6348223.
1983
Metallothionein–aspects related to copper and zinc metabolism.
Journal of inherited metabolic disease. 6 Suppl 1:15-21 [PMID] 6413769.
1983
Physiological ligands for copper and zinc.
Annual review of nutrition. 3:261-88 [PMID] 6357237.
1983
Zinc transport by brush border membrane vesicles from rat intestine.
The Journal of nutrition. 113(7):1434-42 [PMID] 6864341.
1982
Endotoxin-induced changes in copper and zinc metabolism in the Syrian hamster.
The Journal of nutrition. 112(12):2363-73 [PMID] 6128380.
1982
Hormonal regulation of zinc metabolism in a human prostatic carcinoma cell line (PC-3).
Cancer research. 42(1):2-7 [PMID] 7032690.
1982
Induction of kidney metallothionein and metallothionein messenger RNA by zinc and cadmium.
The Journal of nutrition. 112(4):801-9 [PMID] 7069515.
1982
Influence of intraluminal constituents on zinc absorption by isolated, vascularly perfused rat intestine.
The Journal of nutrition. 112(10):1978-82 [PMID] 7119900.
1982
Relationship of metallothionein synthesis and degradation to intracellular zinc metabolism.
Developments in toxicology and environmental science. 9:251-62 [PMID] 6172250.
1981
Hormonal regulation of liver metallothionein zinc: independent and synergistic action of glucagon and glucocorticoids.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 167(2):233-6 [PMID] 6165023.
1981
Induction of hepatic metallothionein by feeding zinc to rats of depleted zinc status.
The American journal of physiology. 240(4):E414-21 [PMID] 7223884.
1981
Metabolism of copper and zinc in isolated rat liver parenchymal cells.
Agents and actions. Supplements. 8:51-64 [PMID] 6937132.
1981
Regulation of intestinal metallothionein biosynthesis in rats by dietary zinc.
The Journal of nutrition. 111(8):1353-61 [PMID] 6115000.
1980
Copper accumulation and metabolism in primary monolayer cultures of rat liver parenchymal cells.
Biochimica et biophysica acta. 629(1):113-25 [PMID] 7370303.
1980
Induction of rat liver metallothionein mRNA and its distribution between free and membrane-bound polyribosomes.
The Biochemical journal. 190(3):755-64 [PMID] 7470077.
1980
Quantitative aspects of zinc absorption by isolated, vascularly perfused rat intestine.
The Journal of nutrition. 110(2):316-23 [PMID] 7354402.
1980
Zinc-binding properties of bovine and human milk in vitro: influence of changes in zinc content.
The American journal of clinical nutrition. 33(5):1083-7 [PMID] 7369157.
1979
Cadmium accumulation and metabolism by rat liver parenchymal cells in primary monolayer culture.
Biochimica et biophysica acta. 583(1):63-72 [PMID] 420870.
1979
Effect of parathyroid hormone on the uptake of orally administered cadmium.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 11(5) [PMID] 478434.
1979
Identification of albumin as the plasma carrier for zinc absorption by perfused rat intestine.
The Biochemical journal. 184(3):627-33 [PMID] 540055.
1979
Metallothionein synthesis and degradation: relationship to cadmium metabolism.
Environmental health perspectives. 28:131-6 [PMID] 488031.
1979
Regulation of liver metallothionein and plasma zinc by the glucocorticoid dexamethasone.
Biochemical and biophysical research communications. 89(4):1120-6 [PMID] 496942.
1979
Regulation of zinc absorption: role of intracellular ligands.
The American journal of clinical nutrition. 32(2):339-45 [PMID] 369351.
1979
Regulatory aspects of zinc metabolism in liver and intestine.
Nutrition reviews. 37(4):97-103 [PMID] 503370.
1979
Synthesis and degradation of liver metallothionein.
Experientia. Supplementum. 34:293-301 [PMID] 299372.
1978
Cell-free synthesis of metallothionein directed by rat liver polyadenylated messenger ribonucleic acid.
The Biochemical journal. 175(3):833-40 [PMID] 743236.
1978
Degradation of cadmium-thionein in rat liver and kidney.
Journal of toxicology and environmental health. 4(5-6):805-13 [PMID] 731729.
1978
Degradation of cadmium-thionein in rat liver and kidney.
Journal of environmental pathology and toxicology. 2(2):463-72 [PMID] 739225.
1978
Degradation of rat liver metallothioneins in vitro.
Biochimica et biophysica acta. 544(3):638-46 [PMID] 728475.
1978
Origin of low molecular weight zinc-binding complexes from rat intestine.
Life sciences. 23(17-18):1819-26 [PMID] 723451.
1978
Zinc absorption and metabolism by isolated, vascularly perfused rat intestine.
The Journal of nutrition. 108(11):1849-57 [PMID] 712429.
1978
Zinc accumulation and metabolism in primary cultures of adult rat liver cells. Regulation by glucocorticoids.
Biochimica et biophysica acta. 543(3):293-304 [PMID] 708788.
1978
Zinc uptake by isolated rat liver parenchymal cells.
Biochimica et biophysica acta. 538(3):435-44 [PMID] 75027.
1977
Biomedical responses of rats to chronic exposure to dietary cadmium fed in ad libitum and equalized regimes.
Journal of toxicology and environmental health. 2(4):929-43 [PMID] 857045.
1977
Control of zinc-thionein synthesis in rat liver.
The Biochemical journal. 164(1):223-8 [PMID] 301740.
1977
Influence of inhibitors of protein synthesis on zinc metabolism.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 156(3):505-8 [PMID] 304217.
1977
Isolation of an intestinal metallothionein induced by parenteral zinc.
Biochemical and biophysical research communications. 75(2):286-94 [PMID] 851439.
1977
Role of dietary calcium and calcium binding protein in cadmium toxicity in rats.
The Journal of nutrition. 107(5):920-8 [PMID] 192863.
1977
Synthesis of metallothionein in a polysomal cell-free system.
Biochemical and biophysical research communications. 75(3):806-12 [PMID] 16595.
1976
Degradation of hepatic zinc-thionein after parenteral zinc administration.
The Biochemical journal. 160(3):583-8 [PMID] 1016240.
1976
Liver and intestinal metallothionein: function in acute cadmium toxicity.
Experimental and molecular pathology. 25(2):163-71 [PMID] 186300.
1976
Metallothionein and its relationship to the metabolism of dietary zinc in rats.
The Journal of nutrition. 106(11):1591-9 [PMID] 978266.
1976
Relationship of mineral status and intake to periodontal disease.
The American journal of clinical nutrition. 29(7):745-9 [PMID] 937229.
1976
Zinc-binding protein: relationship to short term changes in zinc metabolism.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 153(1):52-6 [PMID] 995941.
1975
Double label counting of metal nuclides with 3H or 14C by liquid scintillation counting.
Analytical biochemistry. 65(1-2):412-7 [PMID] 1130686.
1975
Influence of parenteral zinc and actinomycin D on tissue zinc uptake and the synthesis of a zinc – binding protein.
Bioinorganic chemistry. 4(3):215-24 [PMID] 1125336.
1975
Inhibition of leukocyte candidacidal activity by serum from patients with disseminated candidiasis.
The Journal of laboratory and clinical medicine. 86(4):657-66 [PMID] 1100740.
1975
Mammalian zinc homeostasis: requirement for RNA and metallothionein synthesis.
Biochemical and biophysical research communications. 64(4):1215-23 [PMID] 1137597.
1974
Control of cadmium binding protein synthesis in rat liver.
Environmental physiology & biochemistry. 4(1):24-30 [PMID] 4459120.
1973
Cadmium toxicity in growing swine.
The Journal of nutrition. 103(7):964-72 [PMID] 4716195.
1970
Metaboism of 25-hydroxycholecalciferol in target and nontarget tissues.
Biochemistry. 9(19):3649-52 [PMID] 4323609.
1969
Biochemical constituents of the dura mater in vitamin A deficiency.
The Journal of nutrition. 97(3):409-18 [PMID] 4237584.

Grants

Sep 2021 ACTIVE
Function of Metal Transporter ZIP14 as Regulated by Proinflammatory Stimuli
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2017 – Sep 2021
Function of Metal Transporter ZIP14 as Regulated by Proinflammatory Stimuli
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Feb 2015 – Jan 2021
Function of metal transporter ZIP14 as regulated by proinflammatory stimuli (Trans)
Role: Principal Investigator
Funding: UF FOUNDATION
Sep 2011 – Jun 2017
Function of metal transporter ZIP14 as regulated by proinflammatory stimuli
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK

Education

Post Doctoral – Biochemistry
1968-1971 · University of Wisconsin, Madison
Ph.D. – Nutritional Biochemistry
1968 · University of Connecticut, Storrs
M.S. – Animal Sciences
1965 · University of Connecticut, Storrs
B.A. – Zoology-Chemistry
1963 · University of Vermont, Burlington

Contact Details

Phones:
Business:
(352) 294-3700
Emails:
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cousins@ufl.edu
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PO Box 110370
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