James B Flanegan,
Professor Emeritus – Biochemistry and Molecular Biology
On This Page
About James B Flanegan
Professor and Chair Bert Flanegan earned his Ph.D. degree in Biochemistry at the University of Michigan in 1975. He joined Dr. David Baltimore’s lab at MIT as an NIH postdoctoral fellow, where he began his research on RNA virus replication. He joined the faculty at the University of Florida in 1978 and rose to the rank of Professor in 1987. He was a Visiting Professor in Dr. Thomas Cech’s lab at the University of Colorado from 1987-88. In 1998, he was named Chair of the Department of Biochemistry and Molecular Biology. Dr. Flanegan served as a member of the NIH Virology Study Section, the Editorial Boards of Virology and Journal of Virology and as the President of the UF College of Medicine Faculty Council. He has received the Sigma Xi Faculty Research Award, UF Research Achievement Award, College of Medicine Faculty Research Prize in Basic Science, UF Research Foundation Professorship and Professorial Excellence Program Award.
Teaching Profile
Courses Taught
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GMS6034 – Advanced Virology I: Genetics and RNA
College of Medicine
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GMS6035 – Advanced Virology II: RNA Viruses
College of Medicine
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BCH6415 – Advanced Molecular and Cell Biology
College of Medicine
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GMS7980 – Research for Doctoral Dissertation
College of Medicine
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GMS7979 – Advanced Research
College of Medicine
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BCH4905 – Biochemistry Senior Research
College of Medicine
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BCH5413 – Mammalian Molecular Biology and Genetics
College of Medicine
Research Profile
RNA viruses cause a wide variety of diseases including poliomyelitis, encephalitis, meningitis, gastroenteritis, hepatitis, myocarditis and respiratory infections. The objective of our research is the characterization of the mechanisms that regulate picornavirus replication. We use both cell-culture and cell-free systems to investigate both poliovirus and coxsackievirus RNA translation, replication and virus assembly. The synthesis of viral RNA and virus in these reactions provides us with efficient systems for biochemical and genetic studies. We are investigating how specific viral and cellular proteins interact with each other and with cis-active sequences in the viral genome to regulate each step in the replication cycle. Overall, these studies will advance the develop-ment of new antiviral therapies and vaccines and will provide new insights into the mechanisms regulating picornavirus RNA replication.
Publications
Academic Articles
Grants
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Improving the activity of diamidines for potential therapeutic use for patients with myotonic dystrophy types 1 and 2
- Role:
- Other
- Funding:
- MYOTONIC DYSTROPHY FOU
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Improving the activity of diamidines for potential therapeutic use for patients with myotonic dystrophy types 1 and 2
- Role:
- Other
- Funding:
- MYOTONIC DYSTROPHY FOU
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Generation of Virus-Free Polio Vaccine Project: Phase IV, To progress Recombinant Poliovirus Virus-Like Particles (VLPs) into Commercially Viable Candidates
- Role:
- Principal Investigator
- Funding:
- UNIVERSITY OF LEEDS via WORLD HLTH ORGANIZATION
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Characterization of Poliovirus VLPs Using a Mammalian Cell-Free System
- Role:
- Principal Investigator
- Funding:
- WORLD HLTH ORGANIZATION
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Characterization of Poliovirus VLPs Using a Mammalian Cell-Free System
- Role:
- Principal Investigator
- Funding:
- WORLD HLTH ORGANIZATION
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IPA AGREEMENT
- Role:
- Principal Investigator
- Funding:
- US DEPT OF VET AFF GAINESVILLE MED CTR
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IPA AGREEMENT
- Role:
- Principal Investigator
- Funding:
- US DEPT OF VET AFF GAINESVILLE MED CTR
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IPA for Brian Cain
- Role:
- Principal Investigator
- Funding:
- US DEPT OF VETERANS AFFAIRS
Contact Details
- Business:
- (352) 294-8396
- Business:
- flanegan@ufl.edu
- Business Mailing:
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PO Box 100245
GAINESVILLE FL 32610 - Business Street:
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CAMPUS BOX 100245
1600 SW ARCHER RD
R3-234A ARB
GAINESVILLE FL 326103003