Mitchell C Gulkis

Mitchell C Gulkis,

GRADUATE AST-R

Department: MD-BIOCHEMISTRY-GENERAL
Business Phone: (352) 294-8391
Business Email: mitchell.gulkis@ufl.edu

Publications

2024
Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway.
Journal of molecular biology. 436(4) [DOI] 10.1016/j.jmb.2023.168410. [PMID] 38135179.
2024
Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents.
RSC medicinal chemistry. 15(3):937-962 [DOI] 10.1039/d3md00648d. [PMID] 38516586.
2024
Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3′-end of nick DNA.
The Journal of biological chemistry. [DOI] 10.1016/j.jbc.2024.107216. [PMID] 38522520.
2024
Unfilled gaps by polβ lead to aberrant ligation by LIG1 at the downstream steps of base excision repair pathway.
Nucleic acids research. [DOI] 10.1093/nar/gkae104. [PMID] 38366780.
2023
Structures of LIG1 active site mutants reveal the importance of DNA end rigidity for mismatch discrimination.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.03.21.533718. [PMID] 36993234.
2023
Structures of LIG1 active site mutants reveal the importance of DNA end rigidity for mismatch discrimination.
Research square. [DOI] 10.21203/rs.3.rs-2720903/v1. [PMID] 37090517.
2022
Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair.
Nature communications. 13(1) [DOI] 10.1038/s41467-022-31585-w. [PMID] 35790757.

Contact Details

Phones:
Business:
(352) 294-8391
Emails:
Addresses:
Business Mailing:
P O Box 100245
Biochemistry & Molecular Biology
GAINESVILLE FL 32610
Business Street:
1200 NEWELL DR
GAINESVILLE FL 32610