Mitchell C Gulkis,
GRADUATE AST-R
Department:
MD-BIOCHEMISTRY-GENERAL
Business Phone:
(352) 294-8391
Business Email:
mitchell.gulkis@ufl.edu
Publications
Academic Articles
2024
Biochemical, structural, and single-molecule characterization of LIG1 active site mutants demonstrate role of F635 and F872 residues for faithful ligation.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.11.07.622578.
[PMID] 39574773.
2024
Impact of DNA ligase inhibition on the nick sealing of polβ nucleotide insertion products at the downstream steps of base excision repair pathway.
Mutagenesis.
39(6):263-279
[DOI] 10.1093/mutage/geae013.
[PMID] 38736258.
2024
Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway.
Journal of molecular biology.
436(4)
[DOI] 10.1016/j.jmb.2023.168410.
[PMID] 38135179.
2024
Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents.
RSC medicinal chemistry.
15(3):937-962
[DOI] 10.1039/d3md00648d.
[PMID] 38516586.
2024
Probing the mechanism of nick searching by LIG1 at the single-molecule level.
Nucleic acids research.
52(20):12604-12615
[DOI] 10.1093/nar/gkae865.
[PMID] 39404052.
2024
Structural Characterization of Human Bufavirus 1: Receptor Binding and Endosomal pH-Induced Changes.
Viruses.
16(8)
[DOI] 10.3390/v16081258.
[PMID] 39205232.
2024
Structures of LIG1 provide a mechanistic basis for understanding a lack of sugar discrimination against a ribonucleotide at the 3′-end of nick DNA.
The Journal of biological chemistry.
300(5)
[DOI] 10.1016/j.jbc.2024.107216.
[PMID] 38522520.
2024
Uncovering nick DNA binding by LIG1 at the single-molecule level.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.03.28.587287.
[PMID] 38586032.
2024
Unfilled gaps by polβ lead to aberrant ligation by LIG1 at the downstream steps of base excision repair pathway.
Nucleic acids research.
52(7):3810-3822
[DOI] 10.1093/nar/gkae104.
[PMID] 38366780.
2023
Structures of LIG1 active site mutants reveal the importance of DNA end rigidity for mismatch discrimination.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.03.21.533718.
[PMID] 36993234.
2023
Structures of LIG1 active site mutants reveal the importance of DNA end rigidity for mismatch discrimination.
Research square.
[DOI] 10.21203/rs.3.rs-2720903/v1.
[PMID] 37090517.
2022
Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair.
Nature communications.
13(1)
[DOI] 10.1038/s41467-022-31585-w.
[PMID] 35790757.
Contact Details
Phones:
- Business:
- (352) 294-8391
Emails:
- Business:
- mitchell.gulkis@ufl.edu
Addresses:
- Business Mailing:
-
P O Box 100245
Biochemistry & Molecular Biology
GAINESVILLE FL 32610 - Business Street:
-
1200 NEWELL DR
GAINESVILLE FL 32610