Suming Huang,
CO PROF
Teaching Profile
Courses Taught
2018
GMS7980 Research for Doctoral Dissertation
2014-2018
BCH6415 Advanced Molecular and Cell Biology
2013-2017
BCH7410 Advanced Gene Regulation
2015-2017
GMS6647 Transcriptional and Translational Control of Cell Growth and Proliferation
2009
IDH4917 Undergrad Research
Publications
2021
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.
Nature communications.
12(1)
[DOI] 10.1038/s41467-021-22095-2.
[PMID] 33782403.
2021
Mechanistic Basis for In Vivo Therapeutic Efficacy of CK2 Inhibitor CX-4945 in Acute Myeloid Leukemia.
Cancers.
13(5)
[DOI] 10.3390/cancers13051127.
[PMID] 33807974.
2020
Alteration of CTCF-associated chromatin neighborhood inhibits TAL1-driven oncogenic transcription program and leukemogenesis.
Nucleic acids research.
48(6):3119-3133
[DOI] 10.1093/nar/gkaa098.
[PMID] 32086528.
2020
IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia.
Blood.
136(13):1520-1534
[DOI] 10.1182/blood.2019002655.
[PMID] 32396934.
2019
Erratum for Shen et al., “Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression”.
Molecular and cellular biology.
39(11)
[DOI] 10.1128/MCB.00168-19.
[PMID] 31088916.
2019
Histone deacetylase inhibitor targets CD123/CD47-positive cells and reverse chemoresistance phenotype in acute myeloid leukemia.
Leukemia.
33(4):931-944
[DOI] 10.1038/s41375-018-0279-6.
[PMID] 30291336.
2019
Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity.
Leukemia.
33(11):2720-2731
[DOI] 10.1038/s41375-019-0474-0.
[PMID] 31073152.
2018
CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia.
Blood.
132(8):837-848
[DOI] 10.1182/blood-2017-11-814319.
[PMID] 29760161.
2018
Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression.
Molecular and cellular biology.
38(19)
[DOI] 10.1128/MCB.00197-18.
[PMID] 30012865.
2017
Catching global interactions in vivo.
Cell & bioscience.
7
[DOI] 10.1186/s13578-017-0177-z.
[PMID] 29021892.
2017
Histone deacetylase 1 activates PU.1 gene transcription through regulating TAF9 deacetylation and transcription factor IID assembly.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
31(9):4104-4116
[DOI] 10.1096/fj.201700022R.
[PMID] 28572446.
2017
Histone deacetylase 6 regulates cytokinesis and erythrocyte enucleation through deacetylation of formin protein mDia2.
Haematologica.
102(6):984-994
[DOI] 10.3324/haematol.2016.161513.
[PMID] 28255013.
2017
Splicing Factor Sf3B1(K700E) Mutant Dysregulates Erythroid Differentiation Via Aberrant Alternative Splicing of Transcription Factor Tal1
PLoS One.
12(5)
[DOI] 10.1371/journal.pone.0175523.
[PMID] 28545085.
2017
Tet2 Loss Leads to Hypermutagenicity in Haematopoietic Stem/Progenitor Cells
Nature Communications.
8
[DOI] 10.1038/ncomms15102.
[PMID] 28440315.
2016
High Fractional Occupancy of a Tandem Maf Recognition Element and Its Role in Long-Range β-Globin Gene Regulation.
Molecular and cellular biology.
36(2):238-50
[DOI] 10.1128/MCB.00723-15.
[PMID] 26503787.
2016
HoxBlinc RNA Recruits Set1/MLL Complexes to Activate Hox Gene Expression Patterns and Mesoderm Lineage Development.
Cell reports.
14(1):103-114
[DOI] 10.1016/j.celrep.2015.12.007.
[PMID] 26725110.
2016
Persistent Donor Derived V Delta 4 T Cell Clones May Improve Survival for Recurrent T Cell Acute Lymphoblastic Leukemia After Hsct and Dli
Oncotarget.
7(28):42943-42952
[DOI] 10.18632/oncotarget.10260.
[PMID] 27356746.
2016
Setd1a and Nurf Mediate Chromatin Dynamics and Gene Regulation During Erythroid Lineage Commitment and Differentiation
Nucleic acids research.
44(15):7173-7188
[DOI] 10.1093/nar/gkw327.
[PMID] 27141965.
2016
The Epigenetic Modifier Chd5 Functions As a Novel Tumor Suppressor for Renal Cell Carcinoma and Is Predominantly Inactivated By Promoter Cpg Methylation
Oncotarget.
7(16):21618-21630
[DOI] 10.18632/oncotarget.7822.
[PMID] 26943038.
2016
UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.
Genes & development.
30(5):508-21
[DOI] 10.1101/gad.276790.115.
[PMID] 26944678.
2015
Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer.
Molecular cancer research : MCR.
13(3):461-9
[DOI] 10.1158/1541-7786.MCR-14-0389.
[PMID] 25373480.
2015
Setd1a Regulates Progenitor B-Cell-To-Precursor B-Cell Development Through Histone H3 Lysine 4 Trimethylation and Ig Heavy-Chain Rearrangement
The FASEB's Journal.
29(4):1505-1515
[DOI] 10.1096/fj.14-263061.
[PMID] 25550471.
2014
Characteristics of A20 Gene Polymorphisms in T-Cell Acute Lymphocytic Leukemia
Hematology.
19(8):448-454
[DOI] 10.1179/1607845414Y.0000000160.
[PMID] 24611736.
2014
Dissecting the Function of the Adult Beta-Globin Downstream Promoter Region Using An Artificial Zinc Finger Dna-Binding Domain
Nucleic acids research.
42(7):4363-4374
[DOI] 10.1093/nar/gku107.
[PMID] 24497190.
2014
Histone deacetylase 1 and p300 can directly associate with chromatin and compete for binding in a mutually exclusive manner.
PloS one.
9(4)
[DOI] 10.1371/journal.pone.0094523.
[PMID] 24722339.
2014
hSETD1A regulates Wnt target genes and controls tumor growth of colorectal cancer cells.
Cancer research.
74(3):775-86
[DOI] 10.1158/0008-5472.CAN-13-1400.
[PMID] 24247718.
2014
Overexpression of histone deacetylases in cancer cells is controlled by interplay of transcription factors and epigenetic modulators.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
28(10):4265-79
[DOI] 10.1096/fj.14-250654.
[PMID] 24948597.
2014
The TCR γδ repertoire and relative gene expression characteristics of T-ALL cases with biclonal malignant Vδ1 and Vδ2 T cells.
DNA and cell biology.
33(1):49-56
[DOI] 10.1089/dna.2013.2199.
[PMID] 24329526.
2013
Histone Lysine-Specific Demethylase 1 (Lsd1) Protein Is Involved in Sal-Like Protein 4 (Sall4)-Mediated Transcriptional Repression in Hematopoietic Stem Cells
Journal of Biological Chemistry.
288(48):34719-34728
[DOI] 10.1074/jbc.M113.506568.
[PMID] 24163373.
2013
Usf1 and Hset1a Mediated Epigenetic Modifications Regulate Lineage Differentiation and Hoxb4 Transcription
Plos Genetics.
9(6)
[DOI] 10.1371/journal.pgen.1003524.
[PMID] 23754954.
2012
A T-Cell Specific Element Activates the Tal1 Oncogene Via An Interchromosomal Interaction During Leukemogenesis
Blood.
120
2012
Acetylation of Histone Deacetylase 1 Regulates Nurd Corepressor Complex Activity
Journal of Biological Chemistry.
287(48):40279-40291
[DOI] 10.1074/jbc.M112.349704.
[PMID] 23014989.
2012
Ctcf Mediated Enhancer and Promoter Interaction Regulates Differential Expression of Tal1 Oncogene in Normal and Malignant Hematopoiesis
Blood.
120
2012
Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis.
Oncogene.
31(48):5007-18
[DOI] 10.1038/onc.2012.8.
[PMID] 22310283.
2012
Gata-Binding Protein 4 (Gata-4) and T-Cell Acute Leukemia 1 (Tal1) Regulate Myogenic Differentiation and Erythropoietin Response Via Cross-Talk With Sirtuin1 (Sirt1)
Journal of Biological Chemistry.
287(36):30157-30169
[DOI] 10.1074/jbc.M112.376640.
[PMID] 22773876.
2012
Modulation of histone deacetylase 6 (HDAC6) nuclear import and tubulin deacetylase activity through acetylation.
The Journal of biological chemistry.
287(34):29168-74
[DOI] 10.1074/jbc.M112.371120.
[PMID] 22778253.
2012
T-Cell Acute Leukemia 1 (Tal1) Regulation of Erythropoietin Receptor and Association With Excessive Erythrocytosis
Journal of Biological Chemistry.
287(44):36720-36731
[DOI] 10.1074/jbc.M112.378398.
[PMID] 22982397.
2011
A Barrier-Only Boundary Element Delimits the Formation of Facultative Heterochromatin in Drosophila Melanogaster and Vertebrates
Molecular And Cellular Biology.
31(13):2729-2741
[DOI] 10.1128/MCB.05165-11.
[PMID] 21518956.
2011
Regulation of nucleosome landscape and transcription factor targeting at tissue-specific enhancers by BRG1.
Genome research.
21(10):1650-8
[DOI] 10.1101/gr.121145.111.
[PMID] 21795385.
2011
Role of Helix-Loop-Helix Proteins During Differentiation of Erythroid Cells
Molecular And Cellular Biology.
31(7):1332-1343
[DOI] 10.1128/MCB.01186-10.
[PMID] 21282467.
2010
Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.
Blood.
116:283-94
2010
Essential Role for the Maml1 Co-Activator in T-All.
Blood.
116
2010
H4R3 Methylation Facilitates Beta-Globin Transcription By Regulating Histone Acetyltransferase Binding and H3 Acetylation
Blood.
115(10):2028-2037
[DOI] 10.1182/blood-2009-07-236059.
[PMID] 20068219.
2010
Pka Mediated Phosphorylation of Tal1 Regulates Its Interaction With Lsd1 During Hematopoiesis
Blood.
116
2010
Regulation of Hdac1 Histone Deacetylase Activity During Hematopoesis
Blood.
116:1581-1582
2010
Usf and Nf-E2 Cooperate To Regulate the Recruitment and Activity of Rna Polymerase II in the Beta-Globin Gene Locus
Journal of Biological Chemistry.
285(21):15894-15905
[DOI] 10.1074/jbc.M109.098376.
[PMID] 20236933.
2009
Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells.
The Journal of biological chemistry.
284(30):20130-5
[DOI] 10.1074/jbc.M109.001461.
[PMID] 19491096.
2009
Defective Erythropoiesis in Transgenic Mice Expressing Dominant-Negative Upstream Stimulatory Factor
Molecular And Cellular Biology.
29(21):5900-5910
[DOI] 10.1128/MCB.00419-09.
[PMID] 19704006.
2009
Histone Arginine Methylations: Their Roles in Chromatin Dynamics and Transcriptional Regulation
Bioscience Reports.
29(2):131-141
[DOI] 10.1042/BSR20080176.
[PMID] 19220199.
2009
Lsd1-Mediated Epigenetic Modification Is Required for Tal1 Function and Hematopoiesis
Proceedings of the National Academy of Sciences.
106(25):10141-10146
[DOI] 10.1073/pnas.0900437106.
[PMID] 19497860.
2009
Serine Phosphorylation On Tal1 Regulates Its Interaction With Histone Demethylase Lsd1.
Blood.
114
2009
The Role of Hdac1 Acetylation in Hematopoiesis and Gata-1 Function.
Blood.
114
2009
Trans-Regulation of Histone Deacetylase Activities Through Acetylation
Journal of Biological Chemistry.
284(50):34901-34910
[DOI] 10.1074/jbc.M109.038356.
[PMID] 19822520.
2009
Transcriptional Regulation By Tal1 a Link Between Epigenetic Modifications and Erythropoiesis
Epigenetics.
4:257-261
2008
Mast Cell Transcriptional Networks
Blood Cells, Molecules & Diseases.
41(1):82-90
[DOI] 10.1016/j.bcmd.2008.02.005.
[PMID] 18406636.
2008
Regulation of Chromatin Looping and Transcription By Prmt1 Mediated H4R3 Methylation
Blood.
112
2007
Recruitment of coregulator complexes to the beta-globin gene locus by TFII-I and upstream stimulatory factor.
The FEBS journal.
274(23):6065-73
[PMID] 17970752.
2007
USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.
Molecular and cellular biology.
27(22):7991-8002
[PMID] 17846119.
2006
HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription.
Molecular cell.
22(5):669-79
[PMID] 16762839.
2005
Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications.
Genes & development.
19(16):1885-93
[PMID] 16103216.
2005
SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression.
Blood.
105(8):3330-9
[PMID] 15618465.
2004
Recruitment of histone modifications by USF proteins at a vertebrate barrier element.
Molecular cell.
16(3):453-63
[PMID] 15525517.
2003
Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation.
Molecular and cellular biology.
23(21):7585-99
[PMID] 14560005.
2002
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47.
Molecular and cellular biology.
22(2):412-20
[PMID] 11756538.
Grants
Sep 2015
– Aug 2016
The role of a lincRNA in chromatin structure and hematopoiesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2015
ACTIVE
Florida Academic Cancer Center Alliance Seed Grants
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2015
ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Jan 2014
– Mar 2019
Rapid Induction of apoptosis against viral infection
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Jul 2010
– Jul 2015
the role of HDAC1 acetylation on corepressor complex activity and hematopoiesis
Role: Project Manager
Funding: NATL INST OF HLTH
Contact Details
Phones:
- Business:
- (352) 226-6668
Emails:
- Business:
- sumingh@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100245
GAINESVILLE FL 32610