Matthew E Merritt

Matthew E Merritt,

Associate Professor

Department: MD-BIOCHEM / MOLECULAR BIOL
Business Phone: (352) 294-8397
Business Email: matthewmerritt@ufl.edu

About Matthew E Merritt

Teaching Profile

Courses Taught
2020-2021
BCH6209 Advanced Metabolism: Regulation of Key Reactions in Amino Acid and Nucleotide Metabolism
2020-2023
BCH6208 Advanced Metabolism: Regulation of Key Reactions in Carbohydrate and Lipid Metabolism
2019-2020
BCH6936 Biochemistry Seminar
2016-2018,2020-2023
BCH6207 Advanced Metabolism: Role of Membranes in Signal Transduction and Metabolic Control
2016-2018,2020-2023
BCH6206 Advanced Metabolism
2017,2020-2023
BCH4905 Biochemistry Senior Research
2019-2020
BCH6876 Recent Advances in Membrane Biology
2016-2019,2021
BCH6747 Structural Biology/Advanced Physical Biochemistry: Spectroscopy and Hydrodynamics
2016-2019,2021-2022
BCH6740 Physical Biochemistry/Structural Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
CHM7979 Advanced Research
2018
CHM7980 Research for Doctoral Dissertation
2017,2021
BCH6745 Molecular Structure and Dynamics of NMR Spectroscopy
2017,2021
BCH6745L Molecular Structure and Dynamics by NMR Spectroscopy Laboratory

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-4617-9651

Publications

2022
Application of Counter-wound Multi-arm Spirals in HTS Resonator Design.
IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee. 32(4) [DOI] 10.1109/tasc.2022.3146109. [PMID] 35449718.
2022
Detecting de novo Hepatic Ketogenesis Using Hyperpolarized [2-13C] Pyruvate.
Frontiers in physiology. 13 [DOI] 10.3389/fphys.2022.832403. [PMID] 35197867.
2022
Editorial for “ Whole‐Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [ 1‐ 13 C ]pyruvate MRI”
Journal of Magnetic Resonance Imaging. 56(6):1807-1808 [DOI] 10.1002/jmri.28202.
2022
Enrichment of hepatic glycogen and plasma glucose from H₂ 18 O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice
NMR in Biomedicine. [DOI] 10.1002/nbm.4837.
2022
Ex Vivo Hepatic Perfusion Through the Portal Vein in Mouse.
Journal of visualized experiments : JoVE. (181) [DOI] 10.3791/63154. [PMID] 35343950.
2022
INCA 2.0: A tool for integrated, dynamic modeling of NMR- and MS-based isotopomer measurements and rigorous metabolic flux analysis
Metabolic Engineering. 69:275-285 [DOI] 10.1016/j.ymben.2021.12.009. [PMID] 34965470.
2022
Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy.
Cell reports. 39(6) [DOI] 10.1016/j.celrep.2022.110796. [PMID] 35545051.
2022
Metabolic signatures associated with oncolytic myxoma viral infections.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-15562-3. [PMID] 35871072.
2022
Regulation of Metabolism by Mitochondrial MUL1 E3 Ubiquitin Ligase.
Frontiers in cell and developmental biology. 10 [DOI] 10.3389/fcell.2022.904728. [PMID] 35846359.
2022
Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer
Nutrients. 14(15) [DOI] 10.3390/nu14153020. [PMID] 35893874.
2021
15 N-carnitine, a novel endogenous hyperpolarized MRI probe with long signal lifetime.
Magnetic resonance in medicine. 85(4):1814-1820 [DOI] 10.1002/mrm.28578. [PMID] 33179825.
2021
Application of Carbon-13 Isotopomer Analysis to Assess Perinatal Myocardial Glucose Metabolism in Sheep
Metabolites. 11(1) [DOI] 10.3390/metabo11010033. [PMID] 33466367.
2021
Comparison of selective excitation and multi-echo chemical shift encoding for imaging of hyperpolarized [1-13C]pyruvate.
Journal of magnetic resonance (San Diego, Calif. : 1997). 325 [DOI] 10.1016/j.jmr.2021.106927. [PMID] 33607386.
2021
Deuterated water imaging of the rat brain following metabolism of [ 2 H 7 ]glucose
Magnetic Resonance in Medicine. 85(6):3049-3059 [DOI] 10.1002/mrm.28700. [PMID] 33576535.
2021
Hyperpolarized Dihydroxyacetone Is a Sensitive Probe of Hepatic Gluconeogenic State
Metabolites. 11(7) [DOI] 10.3390/metabo11070441. [PMID] 34357335.
2021
Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease
Molecular Metabolism. 45 [DOI] 10.1016/j.molmet.2020.101154. [PMID] 33359401.
2021
Intraspecific variation in polar and nonpolar metabolite profiles of a threatened Caribbean coral
Metabolomics. 17(7) [DOI] 10.1007/s11306-021-01808-0.
2021
Measuring NQO1 Bioactivation Using [2H7]Glucose
Cancers. 13(16) [DOI] 10.3390/cancers13164165. [PMID] 34439319.
2021
ROS and hypoxia signaling regulate periodic metabolic arousal during insect dormancy to coordinate glucose, amino acid, and lipid metabolism
Proceedings of the National Academy of Sciences. 118(1) [DOI] 10.1073/pnas.2017603118. [PMID] 33372159.
2020
A noninvasive method to study the evolution of extracellular fluid volume in mice using time-domain nuclear magnetic resonance.
American journal of physiology. Renal physiology. 319(1):F115-F124 [DOI] 10.1152/ajprenal.00377.2019. [PMID] 32475134.
2020
Aqueous humor metabolite profile of pseudoexfoliation glaucoma is distinctive
Molecular Omics. 16(5):425-435 [DOI] 10.1039/c9mo00192a.
2020
Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(11):14832-14849 [DOI] 10.1096/fj.202001495R. [PMID] 32918763.
2020
HDO production from [2H7]glucose Quantitatively Identifies Warburg Metabolism.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-65839-8. [PMID] 32483190.
2019
Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon‐13 MRI technology
NMR in Biomedicine. 32(10) [DOI] 10.1002/nbm.3937. [PMID] 29870085.
2019
Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology
Neoplasia. 21(1):1-16 [DOI] 10.1016/j.neo.2018.09.006. [PMID] 30472500.
2019
Kinetic Analysis of Hepatic Metabolism Using Hyperpolarized Dihydroxyacetone
Journal of Chemical Information and Modeling. 59(1):605-614 [DOI] 10.1021/acs.jcim.8b00745. [PMID] 30602117.
2019
Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Cancer Discovery. 9(9):1228-1247 [DOI] 10.1158/2159-8290.cd-19-0152.
2019
Metabolomic profiles differ among unique genotypes of a threatened Caribbean coral.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-42434-0. [PMID] 30988456.
2019
Nuclear Magnetic Resonance Measurement of Metabolic Flux Using 13C and 1H Signals.
Methods in molecular biology (Clifton, N.J.). 1996:29-40 [DOI] 10.1007/978-1-4939-9488-5_3. [PMID] 31127544.
2019
Regulation of renal NaDC1 expression and citrate excretion by NBCe1-A.
American journal of physiology. Renal physiology. 317(2):F489-F501 [DOI] 10.1152/ajprenal.00015.2019. [PMID] 31188034.
2019
Remodeling of substrate consumption in the murine sTAC model of heart failure.
Journal of molecular and cellular cardiology. 134:144-153 [DOI] 10.1016/j.yjmcc.2019.07.007. [PMID] 31340162.
2019
Single-walled carbon nanotubes repress viral-induced defense pathways through oxidative stress.
Nanotoxicology. 13(9):1176-1196 [DOI] 10.1080/17435390.2019.1645903. [PMID] 31328592.
2019
The influence of Ho3+ doping on 13C DNP in the presence of BDPA
Physical Chemistry Chemical Physics. 21(34):18629-18635 [DOI] 10.1039/c9cp03717a. [PMID] 31414686.
2018
A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity
Journal of Biological Chemistry. 293(25):9604-9613 [DOI] 10.1074/jbc.ra118.002838.
2018
In vivo hyperpolarization transfer in a clinical MRI scanner
Magnetic Resonance in Medicine. 80(2):480-487 [DOI] 10.1002/mrm.27154. [PMID] 29488244.
2018
Probing cardiac metabolism by hyperpolarized 13 C MR using an exclusively endogenous substrate mixture and photo‐induced nonpersistent radicals
Magnetic Resonance in Medicine. 79(5):2451-2459 [DOI] 10.1002/mrm.27122. [PMID] 29411415.
2018
Sensitivity enhancement for detection of hyperpolarized 13 C MRI probes with 1 H spin coupling introduced by enzymatic transformation in vivo.
Magnetic resonance in medicine. 80(1):36-41 [DOI] 10.1002/mrm.27000. [PMID] 29193287.
2018
The effect of Ho3+ doping on 13C dynamic nuclear polarization at 5 T
Physical Chemistry Chemical Physics. 20(2):728-731 [DOI] 10.1039/c7cp07198a. [PMID] 29242884.
2017
A comprehensive analysis of myocardial substrate preference emphasizes the need for a synchronized fluxomic/metabolomic research design.
American journal of physiology. Heart and circulatory physiology. 312(6):H1215-H1223 [DOI] 10.1152/ajpheart.00016.2017. [PMID] 28411229.
2017
Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone.
Magnetic resonance in medicine. 77(1):65-73 [DOI] 10.1002/mrm.26525. [PMID] 27859575.
2017
Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies.
Magnetic resonance in medicine. 77(4):1419-1428 [DOI] 10.1002/mrm.26226. [PMID] 27017966.
2017
The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
The Journal of biological chemistry. 292(44):18203-18216 [DOI] 10.1074/jbc.M117.813923. [PMID] 28916726.
2017
Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.
Journal of surgical oncology. 116(1):83-88 [DOI] 10.1002/jso.24624. [PMID] 28346693.
2016
A general chemical shift decomposition method for hyperpolarized (13) C metabolite magnetic resonance imaging.
Magnetic resonance in chemistry : MRC. 54(8):665-73 [DOI] 10.1002/mrc.4435. [PMID] 27060361.
2016
Accelerated chemical shift imaging of hyperpolarized (13) C metabolites.
Magnetic resonance in medicine. 76(4):1033-8 [DOI] 10.1002/mrm.26286. [PMID] 27373705.
2016
Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate.
Scientific reports. 6 [DOI] 10.1038/srep25573. [PMID] 27150735.
2016
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
The Journal of clinical investigation. 126(4) [DOI] 10.1172/JCI86695. [PMID] 27035816.
2015
Development and performance of a 129-GHz dynamic nuclear polarizer in an ultra-wide bore superconducting magnet.
Magma (New York, N.Y.). 28(2):195-205 [DOI] 10.1007/s10334-014-0455-2. [PMID] 25120071.
2015
Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs.
Methods in enzymology. 561:73-106 [DOI] 10.1016/bs.mie.2015.04.006. [PMID] 26358902.
2015
Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism.
Magnetic resonance in medicine. 74(2):312-9 [DOI] 10.1002/mrm.25419. [PMID] 25168480.
2015
Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.
Cancer research. 75(22):4708-17 [DOI] 10.1158/0008-5472.CAN-15-0171. [PMID] 26420214.
2015
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
The Journal of clinical investigation. 125(12):4447-62 [DOI] 10.1172/JCI82204. [PMID] 26571396.
2015
Production of hyperpolarized 13CO2 from [1-13C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production.
Metabolomics : Official journal of the Metabolomic Society. 11(5):1144-1156 [PMID] 26543443.
2014
Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.
Molecular cell. 56(3):414-424 [DOI] 10.1016/j.molcel.2014.09.025. [PMID] 25458842.
2014
Hyperpolarized magnetic resonance as a sensitive detector of metabolic function.
Biochemistry. 53(47):7333-57 [DOI] 10.1021/bi501225t. [PMID] 25369537.
2014
Metabolic characteristics of human hearts preserved for 12 hours by static storage, antegrade perfusion, or retrograde coronary sinus perfusion.
The Journal of thoracic and cardiovascular surgery. 148(5):2310-2315.e1 [DOI] 10.1016/j.jtcvs.2014.02.023. [PMID] 24642559.
2014
Propionate stimulates pyruvate oxidation in the presence of acetate.
American journal of physiology. Heart and circulatory physiology. 307(8):H1134-41 [DOI] 10.1152/ajpheart.00407.2014. [PMID] 25320331.
2014
Real-time detection of hepatic gluconeogenic and glycogenolytic states using hyperpolarized [2-13C]dihydroxyacetone.
The Journal of biological chemistry. 289(52):35859-67 [DOI] 10.1074/jbc.M114.613265. [PMID] 25352600.
2014
Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells.
The Journal of biological chemistry. 289(9):6212-24 [DOI] 10.1074/jbc.M113.543637. [PMID] 24415759.
2013
Dissolution DNP-NMR spectroscopy using galvinoxyl as a polarizing agent.
Journal of magnetic resonance (San Diego, Calif. : 1997). 227:14-9 [DOI] 10.1016/j.jmr.2012.11.006. [PMID] 23246650.
2013
Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP.
Physical chemistry chemical physics : PCCP. 15(24):9800-7 [DOI] 10.1039/c3cp50186h. [PMID] 23676994.
2013
Influence of deuteration in the glassing matrix on 13C dynamic nuclear polarization.
Physical chemistry chemical physics : PCCP. 15(19):7032-5 [DOI] 10.1039/c3cp50750e. [PMID] 23552448.
2012
Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13 C NMR.
NMR in biomedicine. 25(11):1286-94 [DOI] 10.1002/nbm.2801. [PMID] 22451442.
2012
Glucose is an ineffective substrate for preservation of machine perfused donor hearts.
The Journal of surgical research. 173(2):198-205 [DOI] 10.1016/j.jss.2011.05.028. [PMID] 21816432.
2012
Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO.
The journal of physical chemistry. A. 116(21):5129-38 [DOI] 10.1021/jp302399f. [PMID] 22571288.
2012
Nanoparticle-based PARACEST agents: the quenching effect of silica nanoparticles on the CEST signal from surface-conjugated chelates.
Contrast media & molecular imaging. 7(1):19-25 [DOI] 10.1002/cmmi.459. [PMID] 22344876.
2012
Production and NMR characterization of hyperpolarized (107,109)Ag complexes.
Angewandte Chemie (International ed. in English). 51(2):525-7 [DOI] 10.1002/anie.201106073. [PMID] 21998014.
2012
The efficiency of DPPH as a polarising agent for DNP-NMR spectroscopy.
RSC advances. 2(33):12812-12817 [PMID] 23205273.
2011
1H magic angle spinning magnetic resonance spectroscopy for monitoring machine-perfused canine donor heart preservation prior to transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 30(6):730-1 [DOI] 10.1016/j.healun.2011.01.722. [PMID] 21429765.
2011
BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy.
Chemistry (Weinheim an der Bergstrasse, Germany). 17(39):10825-7 [DOI] 10.1002/chem.201102037. [PMID] 21919088.
2011
Could 13C MRI assist clinical decision-making for patients with heart disease?
NMR in biomedicine. 24(8):973-9 [DOI] 10.1002/nbm.1718. [PMID] 21608058.
2011
Differences in regional myocardial perfusion, metabolism, MVO2, and edema after coronary sinus machine perfusion preservation of canine hearts.
ASAIO journal (American Society for Artificial Internal Organs : 1992). 57(6):481-6 [DOI] 10.1097/MAT.0b013e31823769d5. [PMID] 22036719.
2011
DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal.
Journal of the American Chemical Society. 133(22):8673-80 [DOI] 10.1021/ja201880y. [PMID] 21539398.
2011
Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance.
Proceedings of the National Academy of Sciences of the United States of America. 108(47):19084-9 [DOI] 10.1073/pnas.1111247108. [PMID] 22065779.
2011
T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation.
Magnetic resonance in medicine. 66(6):1697-703 [DOI] 10.1002/mrm.22938. [PMID] 21608031.
2011
The effect of 13C enrichment in the glassing matrix on dynamic nuclear polarization of [1-13C]pyruvate.
Physics in medicine and biology. 56(5):N85-92 [DOI] 10.1088/0031-9155/56/5/N01. [PMID] 21285486.
2011
Transfer of hyperpolarization from long T1 storage nuclei to short T1 neighbors using FLOPSY-8.
Journal of magnetic resonance (San Diego, Calif. : 1997). 213(1):187-91 [DOI] 10.1016/j.jmr.2011.09.012. [PMID] 21974998.
2010
Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate.
American journal of physiology. Heart and circulatory physiology. 298(5):H1556-64 [DOI] 10.1152/ajpheart.00656.2009. [PMID] 20207817.
2010
Hyperpolarized 89Y complexes as pH sensitive NMR probes.
Journal of the American Chemical Society. 132(6):1784-5 [DOI] 10.1021/ja910278e. [PMID] 20102196.
2008
Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction.
Hepatology (Baltimore, Md.). 48(5):1487-96 [DOI] 10.1002/hep.22504. [PMID] 18925642.
2008
Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-.
Magnetic resonance in medicine. 60(5):1029-36 [DOI] 10.1002/mrm.21760. [PMID] 18956454.
2008
Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
Diabetes. 57(8):2012-21 [DOI] 10.2337/db08-0226. [PMID] 18469201.
2008
Perfusion preservation versus static preservation for cardiac transplantation: effects on myocardial function and metabolism.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 27(1):93-9 [DOI] 10.1016/j.healun.2007.10.006. [PMID] 18187093.
2008
Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis of 2H glucuronide enrichment.
Magnetic resonance in medicine. 60(3):517-23 [DOI] 10.1002/mrm.21681. [PMID] 18727053.
2007
Benefits of perfusion preservation in canine hearts stored for short intervals.
The Journal of surgical research. 140(2):243-9 [PMID] 17509270.
2007
Dipolar cross-relaxation modulates signal amplitudes in the (1)H NMR spectrum of hyperpolarized [(13)C]formate.
Journal of magnetic resonance (San Diego, Calif. : 1997). 189(2):280-5 [PMID] 17945520.
2007
Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance.
Journal of the American Chemical Society. 129(43):12942-3 [PMID] 17927188.
2007
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR.
Proceedings of the National Academy of Sciences of the United States of America. 104(50):19773-7 [PMID] 18056642.
2006
Adiabatic JHSQC for 13C isotopomer analysis.
Magnetic resonance in chemistry : MRC. 44(4):463-6 [PMID] 16408316.
2006
Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR.
The Biochemical journal. 394(Pt 2):465-73 [PMID] 16288601.
2006
Hepatic UDP-glucose 13C isotopomers from [U-13C]glucose: a simple analysis by 13C NMR of urinary menthol glucuronide.
Magnetic resonance in medicine. 56(5):1121-5 [PMID] 17036288.
2006
Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers.
Proceedings of the National Academy of Sciences of the United States of America. 103(33):12505-10 [PMID] 16895983.
2006
Novel 1H NMR approach to quantitative tissue oximetry using hexamethyldisiloxane.
Magnetic resonance in medicine. 55(4):743-8 [PMID] 16506157.
2006
Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy.
FEBS letters. 580(17):4282-7 [PMID] 16831433.
2005
A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications.
Journal of the American Chemical Society. 127(46):16178-88 [PMID] 16287307.
2005
Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance.
Magnetic resonance in medicine. 53(6):1479-83 [PMID] 15906303.
2005
Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose.
American journal of physiology. Endocrinology and metabolism. 288(4):E654-62 [PMID] 15562253.
2005
Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting.
American journal of physiology. Endocrinology and metabolism. 289(1):E53-61 [PMID] 15797985.
2005
Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI.
Magnetic resonance in medicine. 53(4):790-9 [PMID] 15799055.
2004
Connexin expression and cell coupling fail to reverse the v-src transformed growth characteristics of a Cx43-/- cell line.
Cell communication & adhesion. 11(2-4):103-19 [PMID] 16194879.
2004
Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy.
Magnetic resonance in medicine. 51(4):649-54 [PMID] 15065235.
2004
Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative.
Analytical biochemistry. 327(2):149-55 [PMID] 15051530.
2004
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase.
The Journal of biological chemistry. 279(47):48941-9 [PMID] 15347677.
2003
Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine.
Analytical biochemistry. 312(2):228-34 [PMID] 12531210.
2003
PARACEST agents: modulating MRI contrast via water proton exchange.
Accounts of chemical research. 36(10):783-90 [PMID] 14567712.
2003
Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite binding.
Investigative radiology. 38(12):750-60 [PMID] 14627892.
2003
Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra.
Magnetic resonance in medicine. 50(4):659-63 [PMID] 14523948.
2001
13C isotopomer analysis of glutamate by J-resolved heteronuclear single quantum coherence spectroscopy.
Analytical biochemistry. 289(2):187-95 [PMID] 11161312.
2001
Quantifying tracer levels of (2)H(2)O enrichment from microliter amounts of plasma and urine by (2)H NMR.
Magnetic resonance in medicine. 45(1):156-8 [PMID] 11146497.
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples
. [DOI] 10.1101/2022.07.31.502208.
In-vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma
. [DOI] 10.1101/2022.10.31.514397.

Grants

Sep 2022 ACTIVE
HDO Imaging is a Quantitative Marker of Cerebral Glucose Oxidation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB
Apr 2022 ACTIVE
Imaging Hepatic Energy Metabolism in NAFLD/NASH
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2021 ACTIVE
National Resource for Advanced NMR Technology
Role: Co-Project Director/Principal Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Jan 2021 ACTIVE
National High Magnetic Field Laboratory Renewal 2018-2022
Role: Co-Investigator
Funding: FL STATE UNIV NAT HGH MAGNETIC FIELD LAB via NATL SCIENCE FOU
Jul 2020 ACTIVE
Esterase-Sensitive Hyperpolarized 13C Probes for Simultaneous Imaging of pH and Energy Metabolism
Role: Co-Investigator
Funding: NATL INST OF HLTH NIBIB
Jul 2020 – Jun 2021
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Jun 2020 – Jun 2022
NMR console upgrade for structural biology and metabolomics
Role: Faculty
Funding: NATL INST OF HLTH OD
Mar 2020 ACTIVE
Asparagine Synthetase Deficiency
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2019 – Jun 2020
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Aug 2018 ACTIVE
Metabolomics Consortium Coordinating Center (M3C)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2018 ACTIVE
National High Magnetic Field Laboratory Renewal 2018-2022
Role: Co-Investigator
Funding: FL STATE UNIV via NATL SCIENCE FOU
Aug 2017 – Jun 2019
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Apr 2017 ACTIVE
Metabolic Origins of Nonalcoholic Steatohepatitis
Role: Co-Investigator
Funding: UNIV OF MARYLAND COLLEGE PARK via NATL INST OF HLTH NIDDK
Jan 2017 – Dec 2018
National High Magnetic Field Laboratory (NHMFL) PostDoc Salary Support
Role: Principal Investigator
Funding: FL STATE UNIV NAT HGH MAGNETIC FIELD LAB via FL LEGISLATURE
Dec 2016 – Nov 2022
Effects of maternal cortisol on perinatal cardiac metabolism and function
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2016 – Jun 2022
Imaging Hepatic Gluconeogenesis with Hyperpolarized Dihydroxyacetone
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Mar 2016 – Apr 2017
Hyperpolarized 13C imaging for studying beta-oxidative
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB
Sep 2013 – Aug 2019
Southeast Resource Center for Integrated Metabolomics (SECIM)
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jan 2013 – Dec 2018
National High Magnetic Field Laboratory
Role: Co-Investigator
Funding: FL STATE UNIV via NATL SCIENCE FOU

Contact Details

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Business:
(352) 294-8397
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PO Box 100245
GAINESVILLE FL 32610