Matthew E Merritt, Ph.D.
Professor; Coordinator BMS/BMB PhD Program
Department:
MD-BIOCHEM / MOLECULAR BIOL
Business Phone:
(352) 294-8397
Business Email:
matthewmerritt@ufl.edu
About Matthew E Merritt
Related Links:
Teaching Profile
Courses Taught
2020-2021,2024
BCH6209 Advanced Metabolism: Regulation of Key Reactions in Amino Acid and Nucleotide Metabolism
2020-2024
BCH6208 Advanced Metabolism: Regulation of Key Reactions in Carbohydrate and Lipid Metabolism
2019-2020
BCH6936 Biochemistry Seminar
2016-2018,2020-2023
BCH6207 Advanced Metabolism: Role of Membranes in Signal Transduction and Metabolic Control
2016-2018,2020-2024
BCH6206 Advanced Metabolism
2017,2020-2024
BCH4905 Biochemistry Senior Research
2019-2020
BCH6876 Recent Advances in Membrane Biology
2016-2019,2021
BCH6747 Structural Biology/Advanced Physical Biochemistry: Spectroscopy and Hydrodynamics
2016-2019,2021-2022
BCH6740 Physical Biochemistry/Structural Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
CHM7979 Advanced Research
2018
CHM7980 Research for Doctoral Dissertation
2017,2021-2023,2023-2024
BCH6745 Molecular Structure and Dynamics of NMR Spectroscopy
2017,2021
BCH6745L Molecular Structure and Dynamics by NMR Spectroscopy Laboratory
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-4617-9651
Publications
2024
A global view of T cell metabolism in systemic lupus erythematosus.
Frontiers in immunology.
15
[DOI] 10.3389/fimmu.2024.1371708.
[PMID] 38756769.
2024
Age-Related Differences in Affective Behaviors in Mice: Possible Role of Prefrontal Cortical-Hippocampal Functional Connectivity and Metabolomic Profiles.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.11.13.566691.
[PMID] 38014219.
2024
Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolomic profiles.
Frontiers in aging neuroscience.
16
[DOI] 10.3389/fnagi.2024.1356086.
[PMID] 38524115.
2024
Detecting altered hepatic lipid oxidation by MRI in an animal model of MASLD
Cell Reports Medicine.
[DOI] 10.1016/j.xcrm.2024.101714.
2024
Inactivation of mitochondrial MUL1 E3 ubiquitin ligase deregulates mitophagy and prevents diet-induced obesity in mice.
Frontiers in molecular biosciences.
11
[DOI] 10.3389/fmolb.2024.1397565.
[PMID] 38725872.
2023
A method for measurement of human asparagine synthetase (ASNS) activity and application to ASNS protein variants associated with ASNS deficiency
Biology Methods and Protocols.
8(1)
[DOI] 10.1093/biomethods/bpad026.
[PMID] 37965492.
2023
Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines.
JIMD reports.
64(2):167-179
[DOI] 10.1002/jmd2.12356.
[PMID] 36873094.
2023
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples.
Cell metabolism.
35(10):1830-1843.e5
[DOI] 10.1016/j.cmet.2023.07.013.
[PMID] 37611583.
2023
Effects of β-caryophyllene and oxygen availability on cholesterol and fatty acids in breast cancer cells.
PloS one.
18(3)
[DOI] 10.1371/journal.pone.0281396.
[PMID] 36893152.
2023
Enrichment of hepatic glycogen and plasma glucose from H₂18O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice
NMR in Biomedicine.
36(2)
[DOI] 10.1002/nbm.4837.
[PMID] 36151589.
2023
Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells
Nutrients.
15(8)
[DOI] 10.3390/nu15081938.
[PMID] 37111157.
2023
MetaVision3D: Automated Framework for the Generation of Spatial Metabolome Atlas in 3D.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.11.27.568931.
[PMID] 38077043.
2023
Observing exocrine pancreas metabolism using a novel pancreas perfusion technique in combination with hyperpolarized [1-13 C]pyruvate.
Magnetic resonance in chemistry : MRC.
61(12):748-758
[DOI] 10.1002/mrc.5382.
[PMID] 37482899.
2023
Segmented Flow Strategies for Integrating Liquid Chromatography–Mass Spectrometry with Nuclear Magnetic Resonance for Lipidomics
Analytical Chemistry.
95(3):1908-1915
[DOI] 10.1021/acs.analchem.2c03974.
[PMID] 36630396.
2023
Spatial Metabolome Lipidome and Glycome from a Single brain Section.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.07.22.550155.
[PMID] 37546843.
2022
Application of Counter-wound Multi-arm Spirals in HTS Resonator Design.
IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee.
32(4)
[DOI] 10.1109/tasc.2022.3146109.
[PMID] 35449718.
2022
Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency.
The Journal of biological chemistry.
298(9)
[DOI] 10.1016/j.jbc.2022.102385.
[PMID] 35985424.
2022
Detecting de novo Hepatic Ketogenesis Using Hyperpolarized [2-13C] Pyruvate.
Frontiers in physiology.
13
[DOI] 10.3389/fphys.2022.832403.
[PMID] 35197867.
2022
Editorial for “Whole‐Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1‐13C]pyruvate MRI”
Journal of Magnetic Resonance Imaging.
56(6):1807-1808
[DOI] 10.1002/jmri.28202.
2022
Ex Vivo Hepatic Perfusion Through the Portal Vein in Mouse.
Journal of visualized experiments : JoVE.
(181)
[DOI] 10.3791/63154.
[PMID] 35343950.
2022
Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in 13C NMR Spectroscopy.
Journal of physics. Conference series.
2323(1)
[DOI] 10.1088/1742-6596/2323/1/012030.
[PMID] 36187328.
2022
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma
Science Advances.
8(50)
[DOI] 10.1126/sciadv.abp8293.
[PMID] 36525494.
2022
INCA 2.0: A tool for integrated, dynamic modeling of NMR- and MS-based isotopomer measurements and rigorous metabolic flux analysis
Metabolic Engineering.
69:275-285
[DOI] 10.1016/j.ymben.2021.12.009.
[PMID] 34965470.
2022
Isolated murine skeletal muscles utilize pyruvate over glucose for oxidation.
Metabolomics : Official journal of the Metabolomic Society.
18(12)
[DOI] 10.1007/s11306-022-01948-x.
[PMID] 36480060.
2022
Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy.
Cell reports.
39(6)
[DOI] 10.1016/j.celrep.2022.110796.
[PMID] 35545051.
2022
Metabolic signatures associated with oncolytic myxoma viral infections.
Scientific reports.
12(1)
[DOI] 10.1038/s41598-022-15562-3.
[PMID] 35871072.
2022
Regulation of Metabolism by Mitochondrial MUL1 E3 Ubiquitin Ligase.
Frontiers in cell and developmental biology.
10
[DOI] 10.3389/fcell.2022.904728.
[PMID] 35846359.
2022
Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer
Nutrients.
14(15)
[DOI] 10.3390/nu14153020.
[PMID] 35893874.
2021
15 N-carnitine, a novel endogenous hyperpolarized MRI probe with long signal lifetime.
Magnetic resonance in medicine.
85(4):1814-1820
[DOI] 10.1002/mrm.28578.
[PMID] 33179825.
2021
Application of Carbon-13 Isotopomer Analysis to Assess Perinatal Myocardial Glucose Metabolism in Sheep
Metabolites.
11(1)
[DOI] 10.3390/metabo11010033.
[PMID] 33466367.
2021
Comparison of selective excitation and multi-echo chemical shift encoding for imaging of hyperpolarized [1-13C]pyruvate.
Journal of magnetic resonance (San Diego, Calif. : 1997).
325
[DOI] 10.1016/j.jmr.2021.106927.
[PMID] 33607386.
2021
Deuterated water imaging of the rat brain following metabolism of [2H7]glucose
Magnetic Resonance in Medicine.
85(6):3049-3059
[DOI] 10.1002/mrm.28700.
[PMID] 33576535.
2021
Hyperpolarized Dihydroxyacetone Is a Sensitive Probe of Hepatic Gluconeogenic State
Metabolites.
11(7)
[DOI] 10.3390/metabo11070441.
[PMID] 34357335.
2021
Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease
Molecular Metabolism.
45
[DOI] 10.1016/j.molmet.2020.101154.
[PMID] 33359401.
2021
Intraspecific variation in polar and nonpolar metabolite profiles of a threatened Caribbean coral
Metabolomics.
17(7)
[DOI] 10.1007/s11306-021-01808-0.
2021
Measuring NQO1 Bioactivation Using [2H7]Glucose
Cancers.
13(16)
[DOI] 10.3390/cancers13164165.
[PMID] 34439319.
2021
ROS and hypoxia signaling regulate periodic metabolic arousal during insect dormancy to coordinate glucose, amino acid, and lipid metabolism
Proceedings of the National Academy of Sciences.
118(1)
[DOI] 10.1073/pnas.2017603118.
[PMID] 33372159.
2020
A noninvasive method to study the evolution of extracellular fluid volume in mice using time-domain nuclear magnetic resonance.
American journal of physiology. Renal physiology.
319(1):F115-F124
[DOI] 10.1152/ajprenal.00377.2019.
[PMID] 32475134.
2020
Aqueous humor metabolite profile of pseudoexfoliation glaucoma is distinctive
Molecular Omics.
16(5):425-435
[DOI] 10.1039/c9mo00192a.
2020
Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
34(11):14832-14849
[DOI] 10.1096/fj.202001495R.
[PMID] 32918763.
2020
HDO production from [2H7]glucose Quantitatively Identifies Warburg Metabolism.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-020-65839-8.
[PMID] 32483190.
2019
Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon‐13 MRI technology
NMR in Biomedicine.
32(10)
[DOI] 10.1002/nbm.3937.
[PMID] 29870085.
2019
Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology
Neoplasia.
21(1):1-16
[DOI] 10.1016/j.neo.2018.09.006.
[PMID] 30472500.
2019
Kinetic Analysis of Hepatic Metabolism Using Hyperpolarized Dihydroxyacetone
Journal of Chemical Information and Modeling.
59(1):605-614
[DOI] 10.1021/acs.jcim.8b00745.
[PMID] 30602117.
2019
Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Cancer Discovery.
9(9):1228-1247
[DOI] 10.1158/2159-8290.cd-19-0152.
2019
Metabolomic profiles differ among unique genotypes of a threatened Caribbean coral.
Scientific reports.
9(1)
[DOI] 10.1038/s41598-019-42434-0.
[PMID] 30988456.
2019
Nuclear Magnetic Resonance Measurement of Metabolic Flux Using 13C and 1H Signals.
Methods in molecular biology (Clifton, N.J.).
1996:29-40
[DOI] 10.1007/978-1-4939-9488-5_3.
[PMID] 31127544.
2019
Regulation of renal NaDC1 expression and citrate excretion by NBCe1-A.
American journal of physiology. Renal physiology.
317(2):F489-F501
[DOI] 10.1152/ajprenal.00015.2019.
[PMID] 31188034.
2019
Remodeling of substrate consumption in the murine sTAC model of heart failure.
Journal of molecular and cellular cardiology.
134:144-153
[DOI] 10.1016/j.yjmcc.2019.07.007.
[PMID] 31340162.
2019
Single-walled carbon nanotubes repress viral-induced defense pathways through oxidative stress.
Nanotoxicology.
13(9):1176-1196
[DOI] 10.1080/17435390.2019.1645903.
[PMID] 31328592.
2019
The influence of Ho3+ doping on 13C DNP in the presence of BDPA
Physical Chemistry Chemical Physics.
21(34):18629-18635
[DOI] 10.1039/c9cp03717a.
[PMID] 31414686.
2018
A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity
Journal of Biological Chemistry.
293(25):9604-9613
[DOI] 10.1074/jbc.ra118.002838.
2018
In vivo hyperpolarization transfer in a clinical MRI scanner
Magnetic Resonance in Medicine.
80(2):480-487
[DOI] 10.1002/mrm.27154.
[PMID] 29488244.
2018
Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo‐induced nonpersistent radicals
Magnetic Resonance in Medicine.
79(5):2451-2459
[DOI] 10.1002/mrm.27122.
[PMID] 29411415.
2018
Sensitivity enhancement for detection of hyperpolarized 13 C MRI probes with 1 H spin coupling introduced by enzymatic transformation in vivo.
Magnetic resonance in medicine.
80(1):36-41
[DOI] 10.1002/mrm.27000.
[PMID] 29193287.
2018
The effect of Ho3+ doping on 13C dynamic nuclear polarization at 5 T
Physical Chemistry Chemical Physics.
20(2):728-731
[DOI] 10.1039/c7cp07198a.
[PMID] 29242884.
2017
A comprehensive analysis of myocardial substrate preference emphasizes the need for a synchronized fluxomic/metabolomic research design.
American journal of physiology. Heart and circulatory physiology.
312(6):H1215-H1223
[DOI] 10.1152/ajpheart.00016.2017.
[PMID] 28411229.
2017
Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone.
Magnetic resonance in medicine.
77(1):65-73
[DOI] 10.1002/mrm.26525.
[PMID] 27859575.
2017
Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies.
Magnetic resonance in medicine.
77(4):1419-1428
[DOI] 10.1002/mrm.26226.
[PMID] 27017966.
2017
The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
The Journal of biological chemistry.
292(44):18203-18216
[DOI] 10.1074/jbc.M117.813923.
[PMID] 28916726.
2017
Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.
Journal of surgical oncology.
116(1):83-88
[DOI] 10.1002/jso.24624.
[PMID] 28346693.
2016
A general chemical shift decomposition method for hyperpolarized (13) C metabolite magnetic resonance imaging.
Magnetic resonance in chemistry : MRC.
54(8):665-73
[DOI] 10.1002/mrc.4435.
[PMID] 27060361.
2016
Accelerated chemical shift imaging of hyperpolarized (13) C metabolites.
Magnetic resonance in medicine.
76(4):1033-8
[DOI] 10.1002/mrm.26286.
[PMID] 27373705.
2016
Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate.
Scientific reports.
6
[DOI] 10.1038/srep25573.
[PMID] 27150735.
2016
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
The Journal of clinical investigation.
126(4)
[DOI] 10.1172/JCI86695.
[PMID] 27035816.
2015
Development and performance of a 129-GHz dynamic nuclear polarizer in an ultra-wide bore superconducting magnet.
Magma (New York, N.Y.).
28(2):195-205
[DOI] 10.1007/s10334-014-0455-2.
[PMID] 25120071.
2015
Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs.
Methods in enzymology.
561:73-106
[DOI] 10.1016/bs.mie.2015.04.006.
[PMID] 26358902.
2015
Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism.
Magnetic resonance in medicine.
74(2):312-9
[DOI] 10.1002/mrm.25419.
[PMID] 25168480.
2015
Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.
Cancer research.
75(22):4708-17
[DOI] 10.1158/0008-5472.CAN-15-0171.
[PMID] 26420214.
2015
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
The Journal of clinical investigation.
125(12):4447-62
[DOI] 10.1172/JCI82204.
[PMID] 26571396.
2015
Production of hyperpolarized 13CO2 from [1-13C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production.
Metabolomics : Official journal of the Metabolomic Society.
11(5):1144-1156
[PMID] 26543443.
2014
Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.
Molecular cell.
56(3):414-424
[DOI] 10.1016/j.molcel.2014.09.025.
[PMID] 25458842.
2014
Hyperpolarized magnetic resonance as a sensitive detector of metabolic function.
Biochemistry.
53(47):7333-57
[DOI] 10.1021/bi501225t.
[PMID] 25369537.
2014
Metabolic characteristics of human hearts preserved for 12 hours by static storage, antegrade perfusion, or retrograde coronary sinus perfusion.
The Journal of thoracic and cardiovascular surgery.
148(5):2310-2315.e1
[DOI] 10.1016/j.jtcvs.2014.02.023.
[PMID] 24642559.
2014
Propionate stimulates pyruvate oxidation in the presence of acetate.
American journal of physiology. Heart and circulatory physiology.
307(8):H1134-41
[DOI] 10.1152/ajpheart.00407.2014.
[PMID] 25320331.
2014
Real-time detection of hepatic gluconeogenic and glycogenolytic states using hyperpolarized [2-13C]dihydroxyacetone.
The Journal of biological chemistry.
289(52):35859-67
[DOI] 10.1074/jbc.M114.613265.
[PMID] 25352600.
2014
Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells.
The Journal of biological chemistry.
289(9):6212-24
[DOI] 10.1074/jbc.M113.543637.
[PMID] 24415759.
2013
Dissolution DNP-NMR spectroscopy using galvinoxyl as a polarizing agent.
Journal of magnetic resonance (San Diego, Calif. : 1997).
227:14-9
[DOI] 10.1016/j.jmr.2012.11.006.
[PMID] 23246650.
2013
Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP.
Physical chemistry chemical physics : PCCP.
15(24):9800-7
[DOI] 10.1039/c3cp50186h.
[PMID] 23676994.
2013
Influence of deuteration in the glassing matrix on 13C dynamic nuclear polarization.
Physical chemistry chemical physics : PCCP.
15(19):7032-5
[DOI] 10.1039/c3cp50750e.
[PMID] 23552448.
2012
Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13 C NMR.
NMR in biomedicine.
25(11):1286-94
[DOI] 10.1002/nbm.2801.
[PMID] 22451442.
2012
Glucose is an ineffective substrate for preservation of machine perfused donor hearts.
The Journal of surgical research.
173(2):198-205
[DOI] 10.1016/j.jss.2011.05.028.
[PMID] 21816432.
2012
Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO.
The journal of physical chemistry. A.
116(21):5129-38
[DOI] 10.1021/jp302399f.
[PMID] 22571288.
2012
Nanoparticle-based PARACEST agents: the quenching effect of silica nanoparticles on the CEST signal from surface-conjugated chelates.
Contrast media & molecular imaging.
7(1):19-25
[DOI] 10.1002/cmmi.459.
[PMID] 22344876.
2012
Production and NMR characterization of hyperpolarized (107,109)Ag complexes.
Angewandte Chemie (International ed. in English).
51(2):525-7
[DOI] 10.1002/anie.201106073.
[PMID] 21998014.
2012
The efficiency of DPPH as a polarising agent for DNP-NMR spectroscopy.
RSC advances.
2(33):12812-12817
[PMID] 23205273.
2011
1H magic angle spinning magnetic resonance spectroscopy for monitoring machine-perfused canine donor heart preservation prior to transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
30(6):730-1
[DOI] 10.1016/j.healun.2011.01.722.
[PMID] 21429765.
2011
BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy.
Chemistry (Weinheim an der Bergstrasse, Germany).
17(39):10825-7
[DOI] 10.1002/chem.201102037.
[PMID] 21919088.
2011
Could 13C MRI assist clinical decision-making for patients with heart disease?
NMR in biomedicine.
24(8):973-9
[DOI] 10.1002/nbm.1718.
[PMID] 21608058.
2011
Differences in regional myocardial perfusion, metabolism, MVO2, and edema after coronary sinus machine perfusion preservation of canine hearts.
ASAIO journal (American Society for Artificial Internal Organs : 1992).
57(6):481-6
[DOI] 10.1097/MAT.0b013e31823769d5.
[PMID] 22036719.
2011
DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal.
Journal of the American Chemical Society.
133(22):8673-80
[DOI] 10.1021/ja201880y.
[PMID] 21539398.
2011
Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance.
Proceedings of the National Academy of Sciences of the United States of America.
108(47):19084-9
[DOI] 10.1073/pnas.1111247108.
[PMID] 22065779.
2011
T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation.
Magnetic resonance in medicine.
66(6):1697-703
[DOI] 10.1002/mrm.22938.
[PMID] 21608031.
2011
The effect of 13C enrichment in the glassing matrix on dynamic nuclear polarization of [1-13C]pyruvate.
Physics in medicine and biology.
56(5):N85-92
[DOI] 10.1088/0031-9155/56/5/N01.
[PMID] 21285486.
2011
Transfer of hyperpolarization from long T1 storage nuclei to short T1 neighbors using FLOPSY-8.
Journal of magnetic resonance (San Diego, Calif. : 1997).
213(1):187-91
[DOI] 10.1016/j.jmr.2011.09.012.
[PMID] 21974998.
2010
Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate.
American journal of physiology. Heart and circulatory physiology.
298(5):H1556-64
[DOI] 10.1152/ajpheart.00656.2009.
[PMID] 20207817.
2010
Hyperpolarized 89Y complexes as pH sensitive NMR probes.
Journal of the American Chemical Society.
132(6):1784-5
[DOI] 10.1021/ja910278e.
[PMID] 20102196.
2008
Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction.
Hepatology (Baltimore, Md.).
48(5):1487-96
[DOI] 10.1002/hep.22504.
[PMID] 18925642.
2008
Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-.
Magnetic resonance in medicine.
60(5):1029-36
[DOI] 10.1002/mrm.21760.
[PMID] 18956454.
2008
Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
Diabetes.
57(8):2012-21
[DOI] 10.2337/db08-0226.
[PMID] 18469201.
2008
Perfusion preservation versus static preservation for cardiac transplantation: effects on myocardial function and metabolism.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
27(1):93-9
[DOI] 10.1016/j.healun.2007.10.006.
[PMID] 18187093.
2008
Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis of 2H glucuronide enrichment.
Magnetic resonance in medicine.
60(3):517-23
[DOI] 10.1002/mrm.21681.
[PMID] 18727053.
2007
Benefits of perfusion preservation in canine hearts stored for short intervals.
The Journal of surgical research.
140(2):243-9
[PMID] 17509270.
2007
Dipolar cross-relaxation modulates signal amplitudes in the (1)H NMR spectrum of hyperpolarized [(13)C]formate.
Journal of magnetic resonance (San Diego, Calif. : 1997).
189(2):280-5
[PMID] 17945520.
2007
Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance.
Journal of the American Chemical Society.
129(43):12942-3
[PMID] 17927188.
2007
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR.
Proceedings of the National Academy of Sciences of the United States of America.
104(50):19773-7
[PMID] 18056642.
2006
Adiabatic JHSQC for 13C isotopomer analysis.
Magnetic resonance in chemistry : MRC.
44(4):463-6
[PMID] 16408316.
2006
Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR.
The Biochemical journal.
394(Pt 2):465-73
[PMID] 16288601.
2006
Hepatic UDP-glucose 13C isotopomers from [U-13C]glucose: a simple analysis by 13C NMR of urinary menthol glucuronide.
Magnetic resonance in medicine.
56(5):1121-5
[PMID] 17036288.
2006
Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers.
Proceedings of the National Academy of Sciences of the United States of America.
103(33):12505-10
[PMID] 16895983.
2006
Novel 1H NMR approach to quantitative tissue oximetry using hexamethyldisiloxane.
Magnetic resonance in medicine.
55(4):743-8
[PMID] 16506157.
2006
Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy.
FEBS letters.
580(17):4282-7
[PMID] 16831433.
2005
A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications.
Journal of the American Chemical Society.
127(46):16178-88
[PMID] 16287307.
2005
Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance.
Magnetic resonance in medicine.
53(6):1479-83
[PMID] 15906303.
2005
Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose.
American journal of physiology. Endocrinology and metabolism.
288(4):E654-62
[PMID] 15562253.
2005
Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting.
American journal of physiology. Endocrinology and metabolism.
289(1):E53-61
[PMID] 15797985.
2005
Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI.
Magnetic resonance in medicine.
53(4):790-9
[PMID] 15799055.
2004
Connexin expression and cell coupling fail to reverse the v-src transformed growth characteristics of a Cx43-/- cell line.
Cell communication & adhesion.
11(2-4):103-19
[PMID] 16194879.
2004
Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy.
Magnetic resonance in medicine.
51(4):649-54
[PMID] 15065235.
2004
Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative.
Analytical biochemistry.
327(2):149-55
[PMID] 15051530.
2004
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase.
The Journal of biological chemistry.
279(47):48941-9
[PMID] 15347677.
2003
Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine.
Analytical biochemistry.
312(2):228-34
[PMID] 12531210.
2003
PARACEST agents: modulating MRI contrast via water proton exchange.
Accounts of chemical research.
36(10):783-90
[PMID] 14567712.
2003
Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite binding.
Investigative radiology.
38(12):750-60
[PMID] 14627892.
2003
Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra.
Magnetic resonance in medicine.
50(4):659-63
[PMID] 14523948.
2001
13C isotopomer analysis of glutamate by J-resolved heteronuclear single quantum coherence spectroscopy.
Analytical biochemistry.
289(2):187-95
[PMID] 11161312.
2001
Quantifying tracer levels of (2)H(2)O enrichment from microliter amounts of plasma and urine by (2)H NMR.
Magnetic resonance in medicine.
45(1):156-8
[PMID] 11146497.
2000
Connexin43 suppresses MFG-E8 while inducing contact growth inhibition of glioma cells.
Cancer research.
60(21):6018-26
[PMID] 11085522.
Grants
May 2024
ACTIVE
Measuring Exocrine Pancreas Metabolism in Type 1 Diabetes
Role: Other
Funding: NATL INST OF HLTH NIDDK
Apr 2024
ACTIVE
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV
via NATL INST OF HLTH NIGMS
Apr 2023
ACTIVE
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV
via NATL INST OF HLTH NIGMS
Jan 2023
ACTIVE
National High Magnetic Field Laboratory Renewal 2023-2027
Role: Faculty
Funding: FL STATE UNIV
via NATL SCIENCE FOU
Sep 2022
ACTIVE
HDO Imaging is a Quantitative Marker of Cerebral Glucose Oxidation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB
Apr 2022
ACTIVE
Imaging Hepatic Energy Metabolism in NAFLD/NASH
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2021
– Jun 2023
National Resource for Advanced NMR Technology
Role: Co-Project Director/Principal Investigator
Funding: FL STATE UNIV
via NATL INST OF HLTH NIGMS
Jul 2021
– Jun 2022
National Resource for Advanced NMR Technology
Role: Co-Project Director/Principal Investigator
Funding: FL STATE UNIV
via NATL INST OF HLTH NIGMS
Jan 2021
– Dec 2022
National High Magnetic Field Laboratory Renewal 2018-2022
Role: Co-Investigator
Funding: FL STATE UNIV NAT HGH MAGNETIC FIELD LAB
via NATL SCIENCE FOU
Jul 2020
– May 2024
Esterase-Sensitive Hyperpolarized 13C Probes for Simultaneous Imaging of pH and Energy Metabolism
Role: Co-Investigator
Funding: NATL INST OF HLTH NIBIB
Jul 2020
– Jun 2021
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV
via NATL INST OF HLTH NIGMS
Jun 2020
– Jun 2022
NMR console upgrade for structural biology and metabolomics
Role: Faculty
Funding: NATL INST OF HLTH OD
Mar 2020
– Feb 2023
Asparagine Synthetase Deficiency
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2019
– Jun 2020
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV
via NATL INST OF HLTH NIGMS
Aug 2018
– Jun 2023
Metabolomics Consortium Coordinating Center (M3C)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2018
– Dec 2023
National High Magnetic Field Laboratory Renewal 2018-2022
Role: Co-Investigator
Funding: FL STATE UNIV
via NATL SCIENCE FOU
Aug 2017
– Jun 2019
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV
via NATL INST OF HLTH NIGMS
Apr 2017
– Mar 2024
Metabolic Origins of Nonalcoholic Steatohepatitis
Role: Co-Investigator
Funding: UNIV OF MARYLAND COLLEGE PARK
via NATL INST OF HLTH NIDDK
Jan 2017
– Dec 2018
National High Magnetic Field Laboratory (NHMFL) PostDoc Salary Support
Role: Principal Investigator
Funding: FL STATE UNIV NAT HGH MAGNETIC FIELD LAB
via FL LEGISLATURE
Dec 2016
– Nov 2022
Effects of maternal cortisol on perinatal cardiac metabolism and function
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2016
– Jun 2022
Imaging Hepatic Gluconeogenesis with Hyperpolarized Dihydroxyacetone
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Mar 2016
– Apr 2017
Hyperpolarized 13C imaging for studying beta-oxidative
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB
Sep 2013
– Aug 2019
Southeast Resource Center for Integrated Metabolomics (SECIM)
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jan 2013
– Dec 2018
National High Magnetic Field Laboratory
Role: Co-Investigator
Funding: FL STATE UNIV
via NATL SCIENCE FOU
Contact Details
Phones:
- Business:
- (352) 294-8397
Emails:
- Business:
- matthewmerritt@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100245
GAINESVILLE FL 32610 - Business Street:
-
PO Box 100245
GAINESVILLE FL 32610