Matthew E Merritt

Matthew E Merritt, Ph.D.

Associate Professor; Coordinator BMS/BMB PhD Program

Department: MD-BIOCHEM / MOLECULAR BIOL
Business Phone: (352) 294-8397
Business Email: matthewmerritt@ufl.edu

About Matthew E Merritt

Teaching Profile

Courses Taught
2020-2021
BCH6209 Advanced Metabolism: Regulation of Key Reactions in Amino Acid and Nucleotide Metabolism
2020-2023
BCH6208 Advanced Metabolism: Regulation of Key Reactions in Carbohydrate and Lipid Metabolism
2019-2020
BCH6936 Biochemistry Seminar
2016-2018,2020-2023
BCH6207 Advanced Metabolism: Role of Membranes in Signal Transduction and Metabolic Control
2016-2018,2020-2023
BCH6206 Advanced Metabolism
2017,2020-2023
BCH4905 Biochemistry Senior Research
2019-2020
BCH6876 Recent Advances in Membrane Biology
2016-2019,2021
BCH6747 Structural Biology/Advanced Physical Biochemistry: Spectroscopy and Hydrodynamics
2016-2019,2021-2022
BCH6740 Physical Biochemistry/Structural Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
CHM7979 Advanced Research
2018
CHM7980 Research for Doctoral Dissertation
2017,2021-2023,2023
BCH6745 Molecular Structure and Dynamics of NMR Spectroscopy
2017,2021
BCH6745L Molecular Structure and Dynamics by NMR Spectroscopy Laboratory

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-4617-9651

Publications

2024
Age-related differences in affective behaviors in mice: possible role of prefrontal cortical-hippocampal functional connectivity and metabolomic profiles.
Frontiers in aging neuroscience. 16 [DOI] 10.3389/fnagi.2024.1356086. [PMID] 38524115.
2024
Age-Related Differences in Affective Behaviors in Mice: Possible Role of Prefrontal Cortical-Hippocampal Functional Connectivity and Metabolomic Profiles.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.11.13.566691. [PMID] 38014219.
2023
A method for measurement of human asparagine synthetase (ASNS) activity and application to ASNS protein variants associated with ASNS deficiency
Biology Methods and Protocols. 8(1) [DOI] 10.1093/biomethods/bpad026. [PMID] 37965492.
2023
Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines.
JIMD reports. 64(2):167-179 [DOI] 10.1002/jmd2.12356. [PMID] 36873094.
2023
Comprehensive isotopomer analysis of glutamate and aspartate in small tissue samples.
Cell metabolism. 35(10):1830-1843.e5 [DOI] 10.1016/j.cmet.2023.07.013. [PMID] 37611583.
2023
Effects of β-caryophyllene and oxygen availability on cholesterol and fatty acids in breast cancer cells.
PloS one. 18(3) [DOI] 10.1371/journal.pone.0281396. [PMID] 36893152.
2023
Enrichment of hepatic glycogen and plasma glucose from H₂18O informs gluconeogenic and indirect pathway fluxes in naturally feeding mice
NMR in Biomedicine. 36(2) [DOI] 10.1002/nbm.4837. [PMID] 36151589.
2023
Metabolomic Profiling of Asparagine Deprivation in Asparagine Synthetase Deficiency Patient-Derived Cells
Nutrients. 15(8) [DOI] 10.3390/nu15081938. [PMID] 37111157.
2023
MetaVision3D: Automated Framework for the Generation of Spatial Metabolome Atlas in 3D.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.11.27.568931. [PMID] 38077043.
2023
Observing exocrine pancreas metabolism using a novel pancreas perfusion technique in combination with hyperpolarized [1-13 C]pyruvate.
Magnetic resonance in chemistry : MRC. 61(12):748-758 [DOI] 10.1002/mrc.5382. [PMID] 37482899.
2023
Segmented Flow Strategies for Integrating Liquid Chromatography–Mass Spectrometry with Nuclear Magnetic Resonance for Lipidomics
Analytical Chemistry. 95(3):1908-1915 [DOI] 10.1021/acs.analchem.2c03974. [PMID] 36630396.
2023
Spatial Metabolome Lipidome and Glycome from a Single brain Section.
bioRxiv : the preprint server for biology. [DOI] 10.1101/2023.07.22.550155. [PMID] 37546843.
2022
Application of Counter-wound Multi-arm Spirals in HTS Resonator Design.
IEEE transactions on applied superconductivity : a publication of the IEEE Superconductivity Committee. 32(4) [DOI] 10.1109/tasc.2022.3146109. [PMID] 35449718.
2022
Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency.
The Journal of biological chemistry. 298(9) [DOI] 10.1016/j.jbc.2022.102385. [PMID] 35985424.
2022
Detecting de novo Hepatic Ketogenesis Using Hyperpolarized [2-13C] Pyruvate.
Frontiers in physiology. 13 [DOI] 10.3389/fphys.2022.832403. [PMID] 35197867.
2022
Editorial for “Whole‐Abdomen Metabolic Imaging of Healthy Volunteers Using Hyperpolarized [1‐13C]pyruvate MRI”
Journal of Magnetic Resonance Imaging. 56(6):1807-1808 [DOI] 10.1002/jmri.28202.
2022
Ex Vivo Hepatic Perfusion Through the Portal Vein in Mouse.
Journal of visualized experiments : JoVE. (181) [DOI] 10.3791/63154. [PMID] 35343950.
2022
Implementing High Q-Factor HTS Resonators to Enhance Probe Sensitivity in 13C NMR Spectroscopy.
Journal of physics. Conference series. 2323(1) [DOI] 10.1088/1742-6596/2323/1/012030. [PMID] 36187328.
2022
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma
Science Advances. 8(50) [DOI] 10.1126/sciadv.abp8293. [PMID] 36525494.
2022
INCA 2.0: A tool for integrated, dynamic modeling of NMR- and MS-based isotopomer measurements and rigorous metabolic flux analysis
Metabolic Engineering. 69:275-285 [DOI] 10.1016/j.ymben.2021.12.009. [PMID] 34965470.
2022
Isolated murine skeletal muscles utilize pyruvate over glucose for oxidation.
Metabolomics : Official journal of the Metabolomic Society. 18(12) [DOI] 10.1007/s11306-022-01948-x. [PMID] 36480060.
2022
Lipogenesis mediated by OGR1 regulates metabolic adaptation to acid stress in cancer cells via autophagy.
Cell reports. 39(6) [DOI] 10.1016/j.celrep.2022.110796. [PMID] 35545051.
2022
Metabolic signatures associated with oncolytic myxoma viral infections.
Scientific reports. 12(1) [DOI] 10.1038/s41598-022-15562-3. [PMID] 35871072.
2022
Regulation of Metabolism by Mitochondrial MUL1 E3 Ubiquitin Ligase.
Frontiers in cell and developmental biology. 10 [DOI] 10.3389/fcell.2022.904728. [PMID] 35846359.
2022
Synergistic Effect of β-Lapachone and Aminooxyacetic Acid on Central Metabolism in Breast Cancer
Nutrients. 14(15) [DOI] 10.3390/nu14153020. [PMID] 35893874.
2021
15 N-carnitine, a novel endogenous hyperpolarized MRI probe with long signal lifetime.
Magnetic resonance in medicine. 85(4):1814-1820 [DOI] 10.1002/mrm.28578. [PMID] 33179825.
2021
Application of Carbon-13 Isotopomer Analysis to Assess Perinatal Myocardial Glucose Metabolism in Sheep
Metabolites. 11(1) [DOI] 10.3390/metabo11010033. [PMID] 33466367.
2021
Comparison of selective excitation and multi-echo chemical shift encoding for imaging of hyperpolarized [1-13C]pyruvate.
Journal of magnetic resonance (San Diego, Calif. : 1997). 325 [DOI] 10.1016/j.jmr.2021.106927. [PMID] 33607386.
2021
Deuterated water imaging of the rat brain following metabolism of [2H7]glucose
Magnetic Resonance in Medicine. 85(6):3049-3059 [DOI] 10.1002/mrm.28700. [PMID] 33576535.
2021
Hyperpolarized Dihydroxyacetone Is a Sensitive Probe of Hepatic Gluconeogenic State
Metabolites. 11(7) [DOI] 10.3390/metabo11070441. [PMID] 34357335.
2021
Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease
Molecular Metabolism. 45 [DOI] 10.1016/j.molmet.2020.101154. [PMID] 33359401.
2021
Intraspecific variation in polar and nonpolar metabolite profiles of a threatened Caribbean coral
Metabolomics. 17(7) [DOI] 10.1007/s11306-021-01808-0.
2021
Measuring NQO1 Bioactivation Using [2H7]Glucose
Cancers. 13(16) [DOI] 10.3390/cancers13164165. [PMID] 34439319.
2021
ROS and hypoxia signaling regulate periodic metabolic arousal during insect dormancy to coordinate glucose, amino acid, and lipid metabolism
Proceedings of the National Academy of Sciences. 118(1) [DOI] 10.1073/pnas.2017603118. [PMID] 33372159.
2020
A noninvasive method to study the evolution of extracellular fluid volume in mice using time-domain nuclear magnetic resonance.
American journal of physiology. Renal physiology. 319(1):F115-F124 [DOI] 10.1152/ajprenal.00377.2019. [PMID] 32475134.
2020
Aqueous humor metabolite profile of pseudoexfoliation glaucoma is distinctive
Molecular Omics. 16(5):425-435 [DOI] 10.1039/c9mo00192a.
2020
Branched chain amino acids and carbohydrate restriction exacerbate ketogenesis and hepatic mitochondrial oxidative dysfunction during NAFLD.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34(11):14832-14849 [DOI] 10.1096/fj.202001495R. [PMID] 32918763.
2020
HDO production from [2H7]glucose Quantitatively Identifies Warburg Metabolism.
Scientific reports. 10(1) [DOI] 10.1038/s41598-020-65839-8. [PMID] 32483190.
2019
Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon‐13 MRI technology
NMR in Biomedicine. 32(10) [DOI] 10.1002/nbm.3937. [PMID] 29870085.
2019
Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology
Neoplasia. 21(1):1-16 [DOI] 10.1016/j.neo.2018.09.006. [PMID] 30472500.
2019
Kinetic Analysis of Hepatic Metabolism Using Hyperpolarized Dihydroxyacetone
Journal of Chemical Information and Modeling. 59(1):605-614 [DOI] 10.1021/acs.jcim.8b00745. [PMID] 30602117.
2019
Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation
Cancer Discovery. 9(9):1228-1247 [DOI] 10.1158/2159-8290.cd-19-0152.
2019
Metabolomic profiles differ among unique genotypes of a threatened Caribbean coral.
Scientific reports. 9(1) [DOI] 10.1038/s41598-019-42434-0. [PMID] 30988456.
2019
Nuclear Magnetic Resonance Measurement of Metabolic Flux Using 13C and 1H Signals.
Methods in molecular biology (Clifton, N.J.). 1996:29-40 [DOI] 10.1007/978-1-4939-9488-5_3. [PMID] 31127544.
2019
Regulation of renal NaDC1 expression and citrate excretion by NBCe1-A.
American journal of physiology. Renal physiology. 317(2):F489-F501 [DOI] 10.1152/ajprenal.00015.2019. [PMID] 31188034.
2019
Remodeling of substrate consumption in the murine sTAC model of heart failure.
Journal of molecular and cellular cardiology. 134:144-153 [DOI] 10.1016/j.yjmcc.2019.07.007. [PMID] 31340162.
2019
Single-walled carbon nanotubes repress viral-induced defense pathways through oxidative stress.
Nanotoxicology. 13(9):1176-1196 [DOI] 10.1080/17435390.2019.1645903. [PMID] 31328592.
2019
The influence of Ho3+ doping on 13C DNP in the presence of BDPA
Physical Chemistry Chemical Physics. 21(34):18629-18635 [DOI] 10.1039/c9cp03717a. [PMID] 31414686.
2018
A novel inhibitor of pyruvate dehydrogenase kinase stimulates myocardial carbohydrate oxidation in diet-induced obesity
Journal of Biological Chemistry. 293(25):9604-9613 [DOI] 10.1074/jbc.ra118.002838.
2018
In vivo hyperpolarization transfer in a clinical MRI scanner
Magnetic Resonance in Medicine. 80(2):480-487 [DOI] 10.1002/mrm.27154. [PMID] 29488244.
2018
Probing cardiac metabolism by hyperpolarized 13C MR using an exclusively endogenous substrate mixture and photo‐induced nonpersistent radicals
Magnetic Resonance in Medicine. 79(5):2451-2459 [DOI] 10.1002/mrm.27122. [PMID] 29411415.
2018
Sensitivity enhancement for detection of hyperpolarized 13 C MRI probes with 1 H spin coupling introduced by enzymatic transformation in vivo.
Magnetic resonance in medicine. 80(1):36-41 [DOI] 10.1002/mrm.27000. [PMID] 29193287.
2018
The effect of Ho3+ doping on 13C dynamic nuclear polarization at 5 T
Physical Chemistry Chemical Physics. 20(2):728-731 [DOI] 10.1039/c7cp07198a. [PMID] 29242884.
2017
A comprehensive analysis of myocardial substrate preference emphasizes the need for a synchronized fluxomic/metabolomic research design.
American journal of physiology. Heart and circulatory physiology. 312(6):H1215-H1223 [DOI] 10.1152/ajpheart.00016.2017. [PMID] 28411229.
2017
Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13 C]dihydroxyacetone.
Magnetic resonance in medicine. 77(1):65-73 [DOI] 10.1002/mrm.26525. [PMID] 27859575.
2017
Multiband spectral-spatial RF excitation for hyperpolarized [2-13 C]dihydroxyacetone 13 C-MR metabolism studies.
Magnetic resonance in medicine. 77(4):1419-1428 [DOI] 10.1002/mrm.26226. [PMID] 27017966.
2017
The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.
The Journal of biological chemistry. 292(44):18203-18216 [DOI] 10.1074/jbc.M117.813923. [PMID] 28916726.
2017
Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer.
Journal of surgical oncology. 116(1):83-88 [DOI] 10.1002/jso.24624. [PMID] 28346693.
2016
A general chemical shift decomposition method for hyperpolarized (13) C metabolite magnetic resonance imaging.
Magnetic resonance in chemistry : MRC. 54(8):665-73 [DOI] 10.1002/mrc.4435. [PMID] 27060361.
2016
Accelerated chemical shift imaging of hyperpolarized (13) C metabolites.
Magnetic resonance in medicine. 76(4):1033-8 [DOI] 10.1002/mrm.26286. [PMID] 27373705.
2016
Measuring changes in substrate utilization in the myocardium in response to fasting using hyperpolarized [1-(13)C]butyrate and [1-(13)C]pyruvate.
Scientific reports. 6 [DOI] 10.1038/srep25573. [PMID] 27150735.
2016
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
The Journal of clinical investigation. 126(4) [DOI] 10.1172/JCI86695. [PMID] 27035816.
2015
Development and performance of a 129-GHz dynamic nuclear polarizer in an ultra-wide bore superconducting magnet.
Magma (New York, N.Y.). 28(2):195-205 [DOI] 10.1007/s10334-014-0455-2. [PMID] 25120071.
2015
Hyperpolarized (13)C Magnetic Resonance and Its Use in Metabolic Assessment of Cultured Cells and Perfused Organs.
Methods in enzymology. 561:73-106 [DOI] 10.1016/bs.mie.2015.04.006. [PMID] 26358902.
2015
Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism.
Magnetic resonance in medicine. 74(2):312-9 [DOI] 10.1002/mrm.25419. [PMID] 25168480.
2015
Kinetic Modeling and Constrained Reconstruction of Hyperpolarized [1-13C]-Pyruvate Offers Improved Metabolic Imaging of Tumors.
Cancer research. 75(22):4708-17 [DOI] 10.1158/0008-5472.CAN-15-0171. [PMID] 26420214.
2015
Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.
The Journal of clinical investigation. 125(12):4447-62 [DOI] 10.1172/JCI82204. [PMID] 26571396.
2015
Production of hyperpolarized 13CO2 from [1-13C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production.
Metabolomics : Official journal of the Metabolomic Society. 11(5):1144-1156 [PMID] 26543443.
2014
Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.
Molecular cell. 56(3):414-424 [DOI] 10.1016/j.molcel.2014.09.025. [PMID] 25458842.
2014
Hyperpolarized magnetic resonance as a sensitive detector of metabolic function.
Biochemistry. 53(47):7333-57 [DOI] 10.1021/bi501225t. [PMID] 25369537.
2014
Metabolic characteristics of human hearts preserved for 12 hours by static storage, antegrade perfusion, or retrograde coronary sinus perfusion.
The Journal of thoracic and cardiovascular surgery. 148(5):2310-2315.e1 [DOI] 10.1016/j.jtcvs.2014.02.023. [PMID] 24642559.
2014
Propionate stimulates pyruvate oxidation in the presence of acetate.
American journal of physiology. Heart and circulatory physiology. 307(8):H1134-41 [DOI] 10.1152/ajpheart.00407.2014. [PMID] 25320331.
2014
Real-time detection of hepatic gluconeogenic and glycogenolytic states using hyperpolarized [2-13C]dihydroxyacetone.
The Journal of biological chemistry. 289(52):35859-67 [DOI] 10.1074/jbc.M114.613265. [PMID] 25352600.
2014
Simultaneous steady-state and dynamic 13C NMR can differentiate alternative routes of pyruvate metabolism in living cancer cells.
The Journal of biological chemistry. 289(9):6212-24 [DOI] 10.1074/jbc.M113.543637. [PMID] 24415759.
2013
Dissolution DNP-NMR spectroscopy using galvinoxyl as a polarizing agent.
Journal of magnetic resonance (San Diego, Calif. : 1997). 227:14-9 [DOI] 10.1016/j.jmr.2012.11.006. [PMID] 23246650.
2013
Electron spin resonance studies of trityl OX063 at a concentration optimal for DNP.
Physical chemistry chemical physics : PCCP. 15(24):9800-7 [DOI] 10.1039/c3cp50186h. [PMID] 23676994.
2013
Influence of deuteration in the glassing matrix on 13C dynamic nuclear polarization.
Physical chemistry chemical physics : PCCP. 15(19):7032-5 [DOI] 10.1039/c3cp50750e. [PMID] 23552448.
2012
Comparison of kinetic models for analysis of pyruvate-to-lactate exchange by hyperpolarized 13 C NMR.
NMR in biomedicine. 25(11):1286-94 [DOI] 10.1002/nbm.2801. [PMID] 22451442.
2012
Glucose is an ineffective substrate for preservation of machine perfused donor hearts.
The Journal of surgical research. 173(2):198-205 [DOI] 10.1016/j.jss.2011.05.028. [PMID] 21816432.
2012
Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO.
The journal of physical chemistry. A. 116(21):5129-38 [DOI] 10.1021/jp302399f. [PMID] 22571288.
2012
Nanoparticle-based PARACEST agents: the quenching effect of silica nanoparticles on the CEST signal from surface-conjugated chelates.
Contrast media & molecular imaging. 7(1):19-25 [DOI] 10.1002/cmmi.459. [PMID] 22344876.
2012
Production and NMR characterization of hyperpolarized (107,109)Ag complexes.
Angewandte Chemie (International ed. in English). 51(2):525-7 [DOI] 10.1002/anie.201106073. [PMID] 21998014.
2012
The efficiency of DPPH as a polarising agent for DNP-NMR spectroscopy.
RSC advances. 2(33):12812-12817 [PMID] 23205273.
2011
1H magic angle spinning magnetic resonance spectroscopy for monitoring machine-perfused canine donor heart preservation prior to transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 30(6):730-1 [DOI] 10.1016/j.healun.2011.01.722. [PMID] 21429765.
2011
BDPA: an efficient polarizing agent for fast dissolution dynamic nuclear polarization NMR spectroscopy.
Chemistry (Weinheim an der Bergstrasse, Germany). 17(39):10825-7 [DOI] 10.1002/chem.201102037. [PMID] 21919088.
2011
Could 13C MRI assist clinical decision-making for patients with heart disease?
NMR in biomedicine. 24(8):973-9 [DOI] 10.1002/nbm.1718. [PMID] 21608058.
2011
Differences in regional myocardial perfusion, metabolism, MVO2, and edema after coronary sinus machine perfusion preservation of canine hearts.
ASAIO journal (American Society for Artificial Internal Organs : 1992). 57(6):481-6 [DOI] 10.1097/MAT.0b013e31823769d5. [PMID] 22036719.
2011
DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal.
Journal of the American Chemical Society. 133(22):8673-80 [DOI] 10.1021/ja201880y. [PMID] 21539398.
2011
Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance.
Proceedings of the National Academy of Sciences of the United States of America. 108(47):19084-9 [DOI] 10.1073/pnas.1111247108. [PMID] 22065779.
2011
T2 exchange agents: a new class of paramagnetic MRI contrast agent that shortens water T2 by chemical exchange rather than relaxation.
Magnetic resonance in medicine. 66(6):1697-703 [DOI] 10.1002/mrm.22938. [PMID] 21608031.
2011
The effect of 13C enrichment in the glassing matrix on dynamic nuclear polarization of [1-13C]pyruvate.
Physics in medicine and biology. 56(5):N85-92 [DOI] 10.1088/0031-9155/56/5/N01. [PMID] 21285486.
2011
Transfer of hyperpolarization from long T1 storage nuclei to short T1 neighbors using FLOPSY-8.
Journal of magnetic resonance (San Diego, Calif. : 1997). 213(1):187-91 [DOI] 10.1016/j.jmr.2011.09.012. [PMID] 21974998.
2010
Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate.
American journal of physiology. Heart and circulatory physiology. 298(5):H1556-64 [DOI] 10.1152/ajpheart.00656.2009. [PMID] 20207817.
2010
Hyperpolarized 89Y complexes as pH sensitive NMR probes.
Journal of the American Chemical Society. 132(6):1784-5 [DOI] 10.1021/ja910278e. [PMID] 20102196.
2008
Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction.
Hepatology (Baltimore, Md.). 48(5):1487-96 [DOI] 10.1002/hep.22504. [PMID] 18925642.
2008
Inhibition of carbohydrate oxidation during the first minute of reperfusion after brief ischemia: NMR detection of hyperpolarized 13CO2 and H13CO3-.
Magnetic resonance in medicine. 60(5):1029-36 [DOI] 10.1002/mrm.21760. [PMID] 18956454.
2008
Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.
Diabetes. 57(8):2012-21 [DOI] 10.2337/db08-0226. [PMID] 18469201.
2008
Perfusion preservation versus static preservation for cardiac transplantation: effects on myocardial function and metabolism.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 27(1):93-9 [DOI] 10.1016/j.healun.2007.10.006. [PMID] 18187093.
2008
Sources of hepatic glucose production by 2H2O ingestion and Bayesian analysis of 2H glucuronide enrichment.
Magnetic resonance in medicine. 60(3):517-23 [DOI] 10.1002/mrm.21681. [PMID] 18727053.
2007
Benefits of perfusion preservation in canine hearts stored for short intervals.
The Journal of surgical research. 140(2):243-9 [PMID] 17509270.
2007
Dipolar cross-relaxation modulates signal amplitudes in the (1)H NMR spectrum of hyperpolarized [(13)C]formate.
Journal of magnetic resonance (San Diego, Calif. : 1997). 189(2):280-5 [PMID] 17945520.
2007
Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance.
Journal of the American Chemical Society. 129(43):12942-3 [PMID] 17927188.
2007
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR.
Proceedings of the National Academy of Sciences of the United States of America. 104(50):19773-7 [PMID] 18056642.
2006
Adiabatic JHSQC for 13C isotopomer analysis.
Magnetic resonance in chemistry : MRC. 44(4):463-6 [PMID] 16408316.
2006
Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR.
The Biochemical journal. 394(Pt 2):465-73 [PMID] 16288601.
2006
Hepatic UDP-glucose 13C isotopomers from [U-13C]glucose: a simple analysis by 13C NMR of urinary menthol glucuronide.
Magnetic resonance in medicine. 56(5):1121-5 [PMID] 17036288.
2006
Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers.
Proceedings of the National Academy of Sciences of the United States of America. 103(33):12505-10 [PMID] 16895983.
2006
Novel 1H NMR approach to quantitative tissue oximetry using hexamethyldisiloxane.
Magnetic resonance in medicine. 55(4):743-8 [PMID] 16506157.
2006
Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy.
FEBS letters. 580(17):4282-7 [PMID] 16831433.
2005
A new class of macrocyclic lanthanide complexes for cell labeling and magnetic resonance imaging applications.
Journal of the American Chemical Society. 127(46):16178-88 [PMID] 16287307.
2005
Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance.
Magnetic resonance in medicine. 53(6):1479-83 [PMID] 15906303.
2005
Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose.
American journal of physiology. Endocrinology and metabolism. 288(4):E654-62 [PMID] 15562253.
2005
Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting.
American journal of physiology. Endocrinology and metabolism. 289(1):E53-61 [PMID] 15797985.
2005
Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI.
Magnetic resonance in medicine. 53(4):790-9 [PMID] 15799055.
2004
Connexin expression and cell coupling fail to reverse the v-src transformed growth characteristics of a Cx43-/- cell line.
Cell communication & adhesion. 11(2-4):103-19 [PMID] 16194879.
2004
Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy.
Magnetic resonance in medicine. 51(4):649-54 [PMID] 15065235.
2004
Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative.
Analytical biochemistry. 327(2):149-55 [PMID] 15051530.
2004
Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase.
The Journal of biological chemistry. 279(47):48941-9 [PMID] 15347677.
2003
Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine.
Analytical biochemistry. 312(2):228-34 [PMID] 12531210.
2003
PARACEST agents: modulating MRI contrast via water proton exchange.
Accounts of chemical research. 36(10):783-90 [PMID] 14567712.
2003
Silencing of phosphonate-gadolinium magnetic resonance imaging contrast by hydroxyapatite binding.
Investigative radiology. 38(12):750-60 [PMID] 14627892.
2003
Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra.
Magnetic resonance in medicine. 50(4):659-63 [PMID] 14523948.
2001
13C isotopomer analysis of glutamate by J-resolved heteronuclear single quantum coherence spectroscopy.
Analytical biochemistry. 289(2):187-95 [PMID] 11161312.
2001
Quantifying tracer levels of (2)H(2)O enrichment from microliter amounts of plasma and urine by (2)H NMR.
Magnetic resonance in medicine. 45(1):156-8 [PMID] 11146497.
2000
Connexin43 suppresses MFG-E8 while inducing contact growth inhibition of glioma cells.
Cancer research. 60(21):6018-26 [PMID] 11085522.

Grants

May 2024 ACTIVE
Measuring Exocrine Pancreas Metabolism in Type 1 Diabetes
Role: Other
Funding: NATL INST OF HLTH NIDDK
Apr 2024 ACTIVE
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Apr 2023 – Mar 2024
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Jan 2023 ACTIVE
National High Magnetic Field Laboratory Renewal 2023-2027
Role: Faculty
Funding: FL STATE UNIV via NATL SCIENCE FOU
Sep 2022 ACTIVE
HDO Imaging is a Quantitative Marker of Cerebral Glucose Oxidation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB
Apr 2022 ACTIVE
Imaging Hepatic Energy Metabolism in NAFLD/NASH
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2021 – Jun 2023
National Resource for Advanced NMR Technology
Role: Co-Project Director/Principal Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Jul 2021 – Jun 2022
National Resource for Advanced NMR Technology
Role: Co-Project Director/Principal Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Jan 2021 – Dec 2022
National High Magnetic Field Laboratory Renewal 2018-2022
Role: Co-Investigator
Funding: FL STATE UNIV NAT HGH MAGNETIC FIELD LAB via NATL SCIENCE FOU
Jul 2020 – May 2024
Esterase-Sensitive Hyperpolarized 13C Probes for Simultaneous Imaging of pH and Energy Metabolism
Role: Co-Investigator
Funding: NATL INST OF HLTH NIBIB
Jul 2020 – Jun 2021
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Jun 2020 – Jun 2022
NMR console upgrade for structural biology and metabolomics
Role: Faculty
Funding: NATL INST OF HLTH OD
Mar 2020 – Feb 2023
Asparagine Synthetase Deficiency
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2019 – Jun 2020
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Aug 2018 – Jun 2023
Metabolomics Consortium Coordinating Center (M3C)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2018 – Dec 2023
National High Magnetic Field Laboratory Renewal 2018-2022
Role: Co-Investigator
Funding: FL STATE UNIV via NATL SCIENCE FOU
Aug 2017 – Jun 2019
National Resource for Advanced NMR Technology
Role: Co-Investigator
Funding: FL STATE UNIV via NATL INST OF HLTH NIGMS
Apr 2017 – Mar 2024
Metabolic Origins of Nonalcoholic Steatohepatitis
Role: Co-Investigator
Funding: UNIV OF MARYLAND COLLEGE PARK via NATL INST OF HLTH NIDDK
Jan 2017 – Dec 2018
National High Magnetic Field Laboratory (NHMFL) PostDoc Salary Support
Role: Principal Investigator
Funding: FL STATE UNIV NAT HGH MAGNETIC FIELD LAB via FL LEGISLATURE
Dec 2016 – Nov 2022
Effects of maternal cortisol on perinatal cardiac metabolism and function
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Jul 2016 – Jun 2022
Imaging Hepatic Gluconeogenesis with Hyperpolarized Dihydroxyacetone
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Mar 2016 – Apr 2017
Hyperpolarized 13C imaging for studying beta-oxidative
Role: Principal Investigator
Funding: NATL INST OF HLTH NIBIB
Sep 2013 – Aug 2019
Southeast Resource Center for Integrated Metabolomics (SECIM)
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jan 2013 – Dec 2018
National High Magnetic Field Laboratory
Role: Co-Investigator
Funding: FL STATE UNIV via NATL SCIENCE FOU

Contact Details

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Business:
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GAINESVILLE FL 32610
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PO Box 100245
GAINESVILLE FL 32610