Courtesy Faculty

Arthur Edison, Ph.D.

Professor, University of Georgia
(Ph.D., University of Wisconsin-Madison)

Research Interests:  Metabolomics and natural products chemistry to understand the chemical basis of behavior. Our primary organism for this work is Caenorhabditis elegans, a small, free-living nematode. C. elegans has been one of the best studied animals in science, with an extensive genetics, anatomy, cell, and developmental biology knowledge-base. Less is known about the role of small molecules in its development and behavior, and our studies in metabolomics can leverage the extensive understanding of this worm. We also are very interested in other nematodes, including parasitic species.

 

Suming Huang, Ph.D.

Professor, The Penn State University
(Ph.D., Mississippi State University)

Research Interests: Epigenetic mechanism that underlies the controls of the enhancer and promoter interaction during transcriptional activation. We are currently focusing on examining the epigenetic mechanisms by which the chromatin insulator binding factor USF1 maintains a local environment of active chromatin, both by biochemical and functional analysis of the USF1 associated histone modifying enzyme complexes. We are also studying the effects of these complexes on histone modification patterns, local and long-range chromatin structure, and transcriptional regulation.

Another project that my lab is focusing on is the transcriptional regulation of TAL1/SCL, which plays a critical role in normal and malignant hematopoiesis. Activation of TAL1 is the most frequent gain-of-function mutation occurring in T-cell lymphoblastic leukemia (T-ALL). We will use biochemical and cell biology approaches such as protein purification, siRNA knockdown, tissue culture, ChIP-Seq, ChIP, microarray, and in vitro and in vivo transformation assays to determine: 1) the mechanism that triggers the ectopic activation of TAL1 transcription in T-ALL, and 2) the mechanism that dictates the TAL1 transcriptional activity in normal and malignant hematopoiesis.

Suming Huang

Sushma Ogram, Ph.D.

Associate Director Process Development, Brammer Bio, LLC
(Ph.D., University of Tennessee)

 

 

Timothy Osborne, Ph.D.

Sanford Burnham Prebys Medical Discovery Institute, Orlando, Integrative Metabolism Program Director
(Ph.D. from University of California/Los Angeles)

Research Interests: The action of Sterol-Regulatory-Element-Binding Proteins (SREBPs) in nutrient sensing and responses to organic and biological threats; how fundamental processes of gene regulation are used in the control and management of metabolic homeostasis.