Courtesy Faculty
Suming Huang, Ph.D.Professor, The Penn State University Research Interests: Epigenetic mechanism that underlies the controls of the enhancer and promoter interaction during transcriptional activation. Dr. Huang and his lab are currently focusing on examining the epigenetic mechanisms by which the chromatin insulator binding factor USF1 maintains a local environment of active chromatin, both by biochemical and functional analysis of the USF1 associated histone modifying enzyme complexes. His lab is also studying the effects of these complexes on histone modification patterns, local and long-range chromatin structure, and transcriptional regulation. Another project that hislab is focusing on is the transcriptional regulation of TAL1/SCL, which plays a critical role in normal and malignant hematopoiesis. Activation of TAL1 is the most frequent gain-of-function mutation occurring in T-cell lymphoblastic leukemia (T-ALL). His lab will use biochemical and cell biology approaches such as protein purification, siRNA knockdown, tissue culture, ChIP-Seq, ChIP, microarray, and in vitro and in vivo transformation assays to determine: 1) the mechanism that triggers the ectopic activation of TAL1 transcription in T-ALL, and 2) the mechanism that dictates the TAL1 transcriptional activity in normal and malignant hematopoiesis. |
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Sushma Ogram, Ph.D.Associate Director Process Development, Brammer Bio, LLC |
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