Research labs in the department are extremely well equipped for the individual research needs of faculty and students with instruments dedicated to their individual research needs.
In addition, members of the department have access to state-of-the-art core facilities that house multi-user instruments and provide a variety of analytical services. The equipment includes HPLC’s, FPLC’s, steady-state fluorimeters, life-time fluorimeters with laser excitation, UV/VIS spectrophotometers, ultracentrifuges, high resolution magnets for structure determination and imaging, X-ray facilities, sophisticated computing systems for analyzing structural and imaging data as well as modeling, and thermocyclers in addition to standard molecular and biochemical equipment.
Our general research interests are in the dynamic protein-protein and protein-DNA interactions that are required to maintain the structure and to preserve the genetic integrity of DNA.
The focus of the Bungert laboratory is to analyze mechanisms regulating gene expression during erythroid cell differentiation.
The Caglayan Lab studies the molecular determinants of BER pathway fidelity that prevent the release and accumulation of toxic and mutagenic single-strand break intermediates.
The Kladde Lab focuses on understanding the dynamic interplay in transcription between various layers of epigenetic regulation, including nucleosome positioning, histone modifications, and DNA methylation.
The McKenna Lab centers on understanding the structure-function relationships which govern the multitude of intricate interactions required for successful host cell infection by ssDNA viruses.
The overarching goal of the Xie Lab research is to understand how non-coding RNAs and RBPs contribute to gene regulation in human health and disease.