Zhijian Qian

Zhijian Qian, PhD

Professor, Pierre Chagnon Professor Of Cancer Research

Department: MD-HEMATOLOGY/ONCOLOGY
Business Phone: (352) 294-8984

About Zhijian Qian

Zhijian Qian Ph.D. joined Department of Medicine, at the University of Florida in April, 2018. Currently, he is a tenured full Professor. Before that, he had been serving as a tenured Associate Professor of medicine at the University of Illinois at Chicago for several years.

Dr. Qian received his Ph.D. degree from Shanghai Institute of Cell Biology, Chinese Academy of Science, China, and then conducted postdoc training at the University of Illinois at Chicago and the University of Chicago. He established his independent research laboratory in 2010 in the department of Medicine at University of Illinois at Chicago.

Dr. Qian is a scholar of The Leukemia & Lymphoma Society (2018) and Research of the year. His research has been supported by multiple RO1 grants from NIH and other private foundations.

Current Research Interests: The long-term goal of Qian laboratory is to understand the mechanisms that underlie the development of blood cancer with a focus on studying the genetic pathways that control the proliferation, survival and self-renewal of normal or leukemic hematopoietic stem cells, and to identify novel therapeutic strategies for treatment of myeloid malignant diseases. Current my lab research interests include 1) understanding molecular regulation of normal hematopoietic stem cell (HSC) and its leukemic transformation, 2) determining the role and mechanisms of the Wnt/β-catenin signaling in the development and maintenance of myeloid neoplasms, 3) understanding transcriptional, epigenetic and epitranscriptome regulation of normal hematopoiesis and leukemogenesis, 4) studying post-translational modifications of RNA m6A methylation regulators in cancer, and 5) developing novel targeted therapies for myeloid malignant diseases and solid tumors including lung and head-neck cancers.

Teaching Profile

Courses Taught
2020-2023
GMS6647 Transcriptional and Translational Control of Cell Growth and Proliferation
2019
BCH7410 Advanced Gene Regulation

Publications

2022
m6A reader Ythdf3 protects hematopoietic stem cell integrity under stress by promoting the translation of Foxm1 and Asxl1 transcripts.
Haematologica. 107(8):1922-1927 [DOI] 10.3324/haematol.2021.279300. [PMID] 34818872.
2021
A critical role of nuclear m6A reader YTHDC1 in leukemogenesis by regulating MCM complex-mediated DNA replication.
Blood. 138(26):2838-2852 [DOI] 10.1182/blood.2021011707. [PMID] 34255814.
2021
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response.
Nucleic acids research. 49(10):5779-5797 [DOI] 10.1093/nar/gkab415. [PMID] 34048572.
2021
Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice.
Blood. 137(5):610-623 [DOI] 10.1182/blood.2019004688. [PMID] 33538795.
2020
FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML.
Nature communications. 11(1) [DOI] 10.1038/s41467-020-14590-9. [PMID] 32066721.
2020
Inhibition of Slug effectively targets leukemia stem cells via the Slc13a3/ROS signaling pathway.
Leukemia. 34(2):380-390 [DOI] 10.1038/s41375-019-0566-x. [PMID] 31492896.
2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
Cell stem cell. 27(1):64-80.e9 [DOI] 10.1016/j.stem.2020.04.009. [PMID] 32402250.
2020
TFII-I/Gtf2i and Erythro-Megakaryopoiesis.
Frontiers in physiology. 11 [DOI] 10.3389/fphys.2020.590180. [PMID] 33101065.
2019
A critical role of epigenetic inactivation of miR-9 in EVI1high pediatric AML.
Molecular cancer. 18(1) [DOI] 10.1186/s12943-019-0952-z. [PMID] 30813931.
2019
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.
Cancer cell. 35(4):677-691.e10 [DOI] 10.1016/j.ccell.2019.03.006. [PMID] 30991027.
2018
Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension.
American journal of respiratory and critical care medicine. 198(6):788-802 [DOI] 10.1164/rccm.201709-1835OC. [PMID] 29664678.
2018
Forkhead Box M1 Transcriptionally Regulates the Expression of Long Noncoding RNAs Snhg8 and Gm26917 to Promote Proliferation and Survival of Muscle Satellite Cells.
Stem cells (Dayton, Ohio). 36(7):1097-1108 [DOI] 10.1002/stem.2824. [PMID] 29575305.
2018
Genome-wide characterization of lncRNAs in acute myeloid leukemia.
Briefings in bioinformatics. 19(4):627-635 [DOI] 10.1093/bib/bbx007. [PMID] 28203711.
2018
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification.
Cell stem cell. 22(2):191-205.e9 [DOI] 10.1016/j.stem.2017.11.016. [PMID] 29290617.
2018
miR-9 upregulation leads to inhibition of erythropoiesis by repressing FoxO3.
Scientific reports. 8(1) [DOI] 10.1038/s41598-018-24628-0. [PMID] 29695725.
2018
YAP Controls Endothelial Activation and Vascular Inflammation Through TRAF6.
Circulation research. 123(1):43-56 [DOI] 10.1161/CIRCRESAHA.118.313143. [PMID] 29794022.
2017
Current Understanding of Inflammatory Responses in Acute Kidney Injury.
Current gene therapy. 17(6):405-410 [DOI] 10.2174/1566523218666180214092219. [PMID] 29446733.
2016
Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
Haematologica. 101(6):e232-6 [DOI] 10.3324/haematol.2015.139527. [PMID] 26944478.
2015
The transcription factor Foxm1 is essential for the quiescence and maintenance of hematopoietic stem cells.
Nature immunology. 16(8):810-8 [DOI] 10.1038/ni.3204. [PMID] 26147687.
2014
A multicolor panel of TALE-KRAB based transcriptional repressor vectors enabling knockdown of multiple gene targets.
Scientific reports. 4 [DOI] 10.1038/srep07338. [PMID] 25475013.
2014
Endothelial FoxM1 mediates bone marrow progenitor cell-induced vascular repair and resolution of inflammation following inflammatory lung injury.
Stem cells (Dayton, Ohio). 32(7):1855-64 [DOI] 10.1002/stem.1690. [PMID] 24578354.
2013
Apc regulates the function of hematopoietic stem cells largely through β-catenin-dependent mechanisms.
Blood. 121(20):4063-72 [DOI] 10.1182/blood-2012-12-473470. [PMID] 23547052.
2013
Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis.
Proceedings of the National Academy of Sciences of the United States of America. 110(14):5594-9 [DOI] 10.1073/pnas.1302645110. [PMID] 23509296.
2013
Dissecting the roles of miR-302/367 cluster in cellular reprogramming using TALE-based repressor and TALEN.
Stem cell reports. 1(3):218-25 [DOI] 10.1016/j.stemcr.2013.07.002. [PMID] 24319658.
2013
p27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia.
Molecular oncology. 7(6):1069-82 [DOI] 10.1016/j.molonc.2013.07.011. [PMID] 23988911.
2011
The oncoprotein EVI1 and the DNA methyltransferase Dnmt3 co-operate in binding and de novo methylation of target DNA.
PloS one. 6(6) [DOI] 10.1371/journal.pone.0020793. [PMID] 21695170.
2010
Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.
Chemico-biological interactions. 184(1-2):50-7 [DOI] 10.1016/j.cbi.2009.11.025. [PMID] 19958752.
2010
Haploinsufficiency of Apc leads to ineffective hematopoiesis.
Blood. 115(17):3481-8 [DOI] 10.1182/blood-2009-11-251835. [PMID] 20065296.
2009
Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame.
Cell research. 19(3):296-306 [DOI] 10.1038/cr.2009.20. [PMID] 19238173.
2008
A critical role for Apc in hematopoietic stem and progenitor cell survival.
The Journal of experimental medicine. 205(9):2163-75 [DOI] 10.1084/jem.20080578. [PMID] 18725524.
2005
Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation.
The Journal of biological chemistry. 280(26):24931-40 [PMID] 15886202.
2002
Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America. 99(23):14925-30 [PMID] 12417757.

Grants

Sep 2022 ACTIVE
The role of ALKBH5-mediated RNA demethylation in the maintenance of genomic stability in HSPCs
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2022 ACTIVE
The Novel Role and Mechanism of RBM33 in Leukemogenesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
May 2022 ACTIVE
The role of YTHDC1 in normal and malignant hematopoiesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NCI
Jan 2022 ACTIVE
Role of the TET1 short isoform in MDS development and maintenance
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Nov 2021 ACTIVE
Mondello and Davis Startup Funds for Zhijian Qian
Role: Co-Project Director/Principal Investigator
Funding: UF FOUNDATION via JERRY W AND JUDITH S DAVIS CANCER ENDOW
Nov 2021 ACTIVE
Mondello Startup Funds for Zhijian Qian
Role: Co-Project Director/Principal Investigator
Funding: UF FOUNDATION via MONDELLO CANCER CENTER RESEARCH FUND
Sep 2021 – Aug 2022
The role of ALKBH5-mediated RNA demethylation in the maintenance of genomic stability in HSPCs
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jun 2021 – Oct 2021
FOXM1 as a therapeutic target for MLL-rearranged AMLs
Role: Principal Investigator
Funding: FL DEPT OF HLTH LIVE LIKE BELLA
Jun 2021 ACTIVE
The Role of ALKBH5 in Leukemogenesis
Role: Principal Investigator
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Jun 2019 – May 2021
The molecular mechanism of clonal dominance in 5q(del) MDS
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Apr 2019 – Mar 2022
Molecular Basis and Treatment of Pediatric AML with Hyperexpression of EVI1
Role: Principal Investigator
Funding: FL DEPT OF HLTH LIVE LIKE BELLA
Dec 2018 – Mar 2021
The role of EVI1-induced DNA hypermethylation in Leukemogenesis
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2018 ACTIVE
The Role of FOXM1 downregulation in the development of clonal dominance in del(5q) MDS
Role: Principal Investigator
Funding: LEUKEMIA & LYMPHOMA SOC
Nov 2017 – Oct 2022
The Harry T. Mangurian, Jr. Foundation – Support for the Study of Therapy Resistant Leukemia
Role: Project Manager
Funding: UF FOUNDATION via HARRY T MANGURIAN JR FOU

Contact Details

Phones:
Business:
(352) 294-8984
Emails:
Addresses:
Business Mailing:
PO Box 100278
GAINESVILLE FL 32610