Thomas P Yang

Thomas P Yang, Ph.D.

Professor Emeritus

Department: MD-BIOCHEM / MOLECULAR BIOL
Business Phone: (352) 294-8401
Business Email: tpyang@ufl.edu

About Thomas P Yang

Dr. Yang received his A.B. degree from Cornell University and his Ph.D. in Molecular Biology and Biochemistry from the University of California, Irvine. As a postdoctoral fellow, he studied medical and human molecular genetics with Dr. C. Thomas Caskey at the Baylor College of Medicine, and transcriptional regulation with Dr. Arthur D. Riggs at the Beckman Research Institute of the City of Hope. Dr. Yang joined the Dept. of Biochemistry and Molecular Biology in 1988 and rose to the rank of Professor in 1999. He also serves as the Program Director of the Center for Mammalian Genetics, is a member of the American Cancer Society, Florida Division, Peer Review Committee, and was a member of the National Institutes of Health Biological Sciences-1 Study Section.

Teaching Profile

Courses Taught
2013-2020
BCH5413 Mammalian Molecular Biology and Genetics
2013-2014,2016-2019
GMS6001 Fundamentals of Biomedical Sciences I
2013-2014,2016-2019,2018-2019
BCH4905 Biochemistry Senior Research
2019
BCH7410 Advanced Gene Regulation
2007-2011,2013-2019
BCH6415 Advanced Molecular and Cell Biology
2013,2015-2018
BCH7412 Epigenetics of Human Disease and Development
2018
GMS7980 Research for Doctoral Dissertation
2018
ANG7979 Advanced Research
2006-2009,2011-2017
GMS6195 Epigenetics Journal Club
2014
GMS6331 Stem Cell Biology
2010,2012
BCH7414 Advanced Chromatin Structure
2010
IDH4917 Undergrad Research

Research Profile

Our laboratory studies the regulation of transcription, particularly epigenetic mechanisms that regulate activation and silencing of mammalian genes. We employ two genetic systems of monoallelic gene expression: mammalian X chromosome inactivation, and genomic imprinting in the Angelman/Prader-Willi syndrome region of human chromosome 15 and mouse chromosome 7. In each system, both a transcriptionally active and inactive allele of a given gene reside within the same nucleus. We are interested in the mechanisms by which these systems of differential gene expression are established and maintained during mammalian development. Our current studies focus on the roles of DNA methylation and chromatin structure in regulating transcription using mouse genetic models.

Publications

Academic Articles
2020
Early exposure to a methyl donor supplemented diet and the development of repetitive motor behavior in a mouse model.
Developmental psychobiology. 62(1):77-87 [DOI] 10.1002/dev.21914. [PMID] 31512235.
2015
Angelman syndrome imprinting center encodes a transcriptional promoter.
Proceedings of the National Academy of Sciences of the United States of America. 112(22):6871-5 [DOI] 10.1073/pnas.1411261111. [PMID] 25378697.
2015
Correction for Lewis et al., Angelman syndrome imprinting center encodes a transcriptional promoter.
Proceedings of the National Academy of Sciences of the United States of America. 112(22) [DOI] 10.1073/pnas.1500034112. [PMID] 25588880.
2014
Influence of the Prader-Willi syndrome imprinting center on the DNA methylation landscape in the mouse brain.
Epigenetics. 9(11):1540-56 [DOI] 10.4161/15592294.2014.969667. [PMID] 25482058.
2013
Regulatory elements associated with paternally-expressed genes in the imprinted murine Angelman/Prader-Willi syndrome domain.
PloS one. 8(2) [DOI] 10.1371/journal.pone.0052390. [PMID] 23390487.
2012
Epigenetic Alterations and Stress Among New Mothers and Infants in the Democratic Republic of Congo: a Biocultural Look At the Intergenerational Effects of War.
American Journal of Physical Anthropology. 147
2012
Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate’s role.
Advances in nutrition (Bethesda, Md.). 3(1):21-38 [DOI] 10.3945/an.111.000992. [PMID] 22332098.
2011
A new deletion refines the boundaries of the murine Prader-Willi syndrome imprinting center.
Human molecular genetics. 20(17):3461-6 [DOI] 10.1093/hmg/ddr262. [PMID] 21659337.
2011
Are There Changes in Dna Methylation in Response To Chronic Consumption and Withdrawal of Folic Acid in a Population-Based Trial of Reproductive Age Women?
Journal of Developmental Origins of Health and Disease. 2:S126-S127
2011
Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart.
Molecular and cellular biology. 31(22):4633-45 [DOI] 10.1128/MCB.05940-11. [PMID] 21930795.
2011
Genomic DNA methylation changes in response to folic acid supplementation in a population-based intervention study among women of reproductive age.
PloS one. 6(12) [DOI] 10.1371/journal.pone.0028144. [PMID] 22163281.
2011
MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation.
The American journal of clinical nutrition. 93(6):1365-72 [DOI] 10.3945/ajcn.110.004671. [PMID] 21508090.
2010
Improving efficiencies of locus-specific DNA methylation assessment for bovine in vitro produced embryos.
Systems biology in reproductive medicine. 56(1):96-105 [DOI] 10.3109/19396360903331148. [PMID] 20170282.
2009
Assessment of Locus-Specific Dna Methylation: Optimization for Bovine Embryos
Reproduction Fertility and Development. 21(1) [DOI] 10.1071/RDv21n1Ab100.
2009
Nkx2-5-Dependent Transcriptional Regulation of Anf and Bnp Through a Common Distal Enhancer
Circulation. 120
2009
Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway.
Hepatology (Baltimore, Md.). 50(1):282-90 [DOI] 10.1002/hep.22971. [PMID] 19415718.
2008
Locus control region mediated regulation of adult beta-globin gene expression.
Journal of cellular biochemistry. 105(1):9-16 [DOI] 10.1002/jcb.21820. [PMID] 18500726.
2005
Characterization of cis- and trans-acting elements in the imprinted human SNURF-SNRPN locus.
Nucleic acids research. 33(15):4740-53 [PMID] 16116039.
2004
Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.
The Journal of cell biology. 167(6):1025-35 [PMID] 15596546.
2004
Ontogeny of a demethylation domain and its relationship to activation of tissue-specific transcription.
Biology of reproduction. 71(3):837-44 [PMID] 15140797.
2003
Role of the promoter in maintaining transcriptionally active chromatin structure and DNA methylation patterns in vivo.
Molecular and cellular biology. 23(12):4150-61 [PMID] 12773559.

Contact Details

Phones:
Business:
(352) 294-8401
Emails:
Business:
tpyang@ufl.edu
Addresses:
Business Mailing:
PO Box 100245
GAINESVILLE FL 32610
Business Street:
R3295 ARB
GAINESVILLE FL 32611