Jump to: Enzymatic Mechanisms and Structure-Function Relationships | Gene Regulation and the Control of Protein Function | Nucleic Acid-Protein Interactions and Chromatin Structure | Metabolism and In-born errors of metabolism | Macromolecular Structure Determination
Enzymatic Mechanisms and Structure-Function Relationships
- L. Bloom: DNA replication and repair complexes
- M. Caglayan: DNA repair (single-strand and double-strand break repair) complexes
- M. Kladde: Discovery and enzymology of DNA methyltransferases
- Z. Li: Regulation of oxidation-reduction homeostasis
- T. Mareci: Tissue structure and function in the central nervous system
- R. McKenna: Protein and virus crystallography and biophysical methods
- M. Merritt: Quantitative measures of metabolic flux
- M. Xie: MicroRNA processing
- C. Zhao: Molecular mechanisms of membrane protein regulations
Gene Regulation and the Control of Protein Function
- J. Bungert: Beta-globin gene cluster regulation
- M. Kladde: Chromatin remodeling in gene activation; epigenetic silencing of tumor suppressors
- J. Lu: Transcriptional and chromatin regulation of tumor invasion, angiogenesis, and metabolism
- M. Xie: Post-transcriptional gene regulation by RNA interference
Nucleic Acid-Protein Interactions and Chromatin Structure
- M. Caglayan: DNA polymerases and DNA ligases in DNA repair
- L. Bloom: Sliding clamps in DNA replication
- J. Bungert: Chromatin structure and protein binding
- M. Kladde: Single-molecule and population probing of chromatin structure
- J. Lu: Histone modifications and chromatin organization
Metabolism and In-born Errors of Metabolism
- M. Gentry: Defining disease mechanisms and developing pre-clinical therapies
- Z. Li: Lipid metabolism and lipid quality control
- M. Merritt: Energy metabolism, NMR, MR Imaging
- R. Sun: Multidisciplinary investigation on the neurobiology and neurochemistry of the aging brain and the metabolic signaling between the brain-lung axis.
- C. Vander Kooi: Structural biology, molecular interactions glucan kinases and phosphatases, molecular basis of human disease
Macromolecular Structure Determination
- J. Long: Biomolecular structure and dynamics
- T. Mareci: Tissue structure and biochemistry in the nervous system by NMR
- R. McKenna: Actin-protein complexes
- C. Zhao: Cryo-EM structure determination of membrane proteins isolated and/or in cell membrane