About Mingyi Xie
From 2005 to 2010, Dr. Xie’s Ph.D. work focused on investigating the structure and function of vertebrate telomerase, under the guidance of Dr. Julian Chen at Arizona State University. In 2010, he joined the laboratory of Dr. Joan Steitz at Yale University to study non-canonical microRNA (miRNA) biogenesis in Herpesviruses and their mammalian hosts. Dr. Xie joined the faculty at the University of Florida in September, 2016.
Gene expression involves delicate regulation by RNA-binding proteins (RBP), and enzymes that process and modify RNAs. The overarching goal of our research is to understand how non-coding RNAs and RBPs contribute to gene regulation. At present, my lab focuses on two research directions: microRNA lifecycle microRNAs have been shown to affect diverse cellular pathways critical to human development and disease, underscoring the need to elucidate the mechanism by which their levels are regulated. In this direction, we will investigate microRNA biogenesis, function and degradation. RNA metabolism mediated by the Integrator complex Integrator is a multi-functional, 14-subunit protein complex that has been linked to a variety of disease states, including developmental failure, neurodegenerative disease, and cancer. The underlying disease-causing mechanism is attributable to Integrator’s ubiquitous role in RNA expression pathways, but its RNA-recognition mechanism is poorly understood. We will identify the Integrator subunit(s) that recognize target RNAs and determine the RNAs regulated by the Integrator complex.