Robert Mckenna

Robert Mckenna,

PROFESSOR

Department: MD-BIOCHEM / MOLECULAR BIOL
Business Phone: (352) 294-8395
Business Email: rmckenna@ufl.edu

Teaching Profile

Courses Taught
2007-2023
BCH6744 Molecular Structure Determination by X-ray Crystallography
2017-2023
BCH6877 Recent Advances in Structural Biology
2015-2016,2018-2022,2020-2022,2022
GMS6009 Principles of Drug Action and Therapeutics
2008,2011-2015,2015-2020,2017-2020
BCH6749C Numerical Methods in Structural Biology
2008-2022
BCH6746 Structural Biology: Macromolecular Structure Determination
2013-2019,2021-2023
BCH4024 Introduction to Biochemistry and Molecular Biology
2007-2008,2016-2021,2021
GMS5905 Special Topics in Biomedical Sciences
2015-2019
BCH6747 Structural Biology/Advanced Physical Biochemistry: Spectroscopy and Hydrodynamics
2014-2019,2021-2022
BCH6740 Physical Biochemistry/Structural Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
CHM7979 Advanced Research
2018
CHM7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2015-2017
GMS6895 CTS Journal Club
2013,2015-2017
BCH6971 Research for Master’s Thesis
2013-2017
BCH6910 Supervised Research
2013,2015-2017
BCH6905 Independent Studies in Biochemistry and Molecular Biology
2008-2016
BCH6875 Crystallography and Cryo-Electron Microscopy
2007-2011,2015-2021,2021
BCH4905 Biochemistry Senior Research
2011-2013
BCH6936 Biochemistry Seminar
2007-2010
BCH6107 Biophysical Techniques in Proteomics and Protein Science
2021-2023
BCH6744L Molecular Structure Determination by X-Ray Crystallography Laboratory
2021
GMS6003 Fundamentals of Graduate Research and Professional Development
2022-2023
GMS6001 Fundamentals of Biomedical Sciences I

Publications

2022
Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity.
Journal of virology. 96(11) [DOI] 10.1128/jvi.00335-22. [PMID] 35532224.
2022
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.
Journal of medicinal chemistry. 65(1):824-837 [DOI] 10.1021/acs.jmedchem.1c01906. [PMID] 34958217.
2022
Small Molecule Alkoxy Oriented Selectiveness on Human Carbonic Anhydrase II and IX Inhibition.
ChemMedChem. 17(11) [DOI] 10.1002/cmdc.202200148. [PMID] 35388618.
2022
Structural characterization of an envelope-associated adeno-associated virus type 2 capsid.
Virology. 565:22-28 [DOI] 10.1016/j.virol.2021.09.010. [PMID] 34638006.
2022
Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants.
Journal of virology. 96(3) [DOI] 10.1128/JVI.01251-21. [PMID] 34757842.
2022
Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair.
Nature communications. 13(1) [DOI] 10.1038/s41467-022-31585-w. [PMID] 35790757.
2022
The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII.
Journal of enzyme inhibition and medicinal chemistry. 37(1):930-939 [DOI] 10.1080/14756366.2022.2053526. [PMID] 35306936.
2021
Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment.
Journal of virology. 95(19) [DOI] 10.1128/JVI.00843-21. [PMID] 34260280.
2021
Characterization of the GBoV1 Capsid and Its Antibody Interactions.
Viruses. 13(2) [DOI] 10.3390/v13020330. [PMID] 33672786.
2021
Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2.
Journal of structural biology. 213(4) [DOI] 10.1016/j.jsb.2021.107795. [PMID] 34509611.
2021
Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features.
Viruses. 13(1) [DOI] 10.3390/v13010101. [PMID] 33450892.
2021
Erratum: Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase. Corrigendum.
IUCrJ. 8(Pt 2) [DOI] 10.1107/S2052252521000208. [PMID] 33708409.
2021
Handling drug-target selectivity: A study on ureido containing Carbonic Anhydrase inhibitors.
European journal of medicinal chemistry. 212 [DOI] 10.1016/j.ejmech.2020.113035. [PMID] 33303238.
2021
Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids.
Journal of virology. 95(19) [DOI] 10.1128/JVI.00773-21. [PMID] 34287038.
2021
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.
Journal of medicinal chemistry. 64(3):1713-1724 [DOI] 10.1021/acs.jmedchem.0c02077. [PMID] 33523653.
2021
pH-Induced Conformational Changes of Human Bocavirus Capsids.
Journal of virology. 95(8) [DOI] 10.1128/JVI.02329-20. [PMID] 33472934.
2021
Receptor Switching in Newly Evolved Adeno-associated Viruses.
Journal of virology. 95(19) [DOI] 10.1128/JVI.00587-21. [PMID] 34232726.
2021
Structural Study of Aavrh.10 Receptor and Antibody Interactions.
Journal of virology. 95(23) [DOI] 10.1128/JVI.01249-21. [PMID] 34549984.
2020
“A Sweet Combination”: Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
Journal of medicinal chemistry. 63(1):321-333 [DOI] 10.1021/acs.jmedchem.9b01669. [PMID] 31794211.
2020
Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking.
Viruses. 12(6) [DOI] 10.3390/v12060668. [PMID] 32575696.
2020
An arrestin-1 surface opposite of its interface with photoactivated rhodopsin engages with enolase-1.
The Journal of biological chemistry. 295(19):6498-6508 [DOI] 10.1074/jbc.RA120.013043. [PMID] 32238431.
2020
Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II.
Biomolecules. 10(4) [DOI] 10.3390/biom10040527. [PMID] 32244293.
2020
Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX.
International journal of molecular sciences. 21(15) [DOI] 10.3390/ijms21155277. [PMID] 32722392.
2020
CAIX forms a transport metabolon with monocarboxylate transporters in human breast cancer cells.
Oncogene. 39(8):1710-1723 [DOI] 10.1038/s41388-019-1098-6. [PMID] 31723238.
2020
Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies.
Molecular therapy. Methods & clinical development. 19:362-373 [DOI] 10.1016/j.omtm.2020.10.001. [PMID] 33145372.
2020
Characterization of an intermolecular quaternary interaction between discrete segments of the Streptococcus mutans adhesin P1 by NMR spectroscopy.
The FEBS journal. 287(12):2597-2611 [DOI] 10.1111/febs.15158. [PMID] 31782893.
2020
Comparative Analysis of the Capsid Structures of AAVrh.10, AAVrh.39, and AAV8.
Journal of virology. 94(6) [DOI] 10.1128/JVI.01769-19. [PMID] 31826994.
2020
Deep Analysis of Residue Constraints (DARC): identifying determinants of protein functional specificity.
Scientific reports. 10(1) [DOI] 10.1038/s41598-019-55118-6. [PMID] 32015389.
2020
Elucidating the role of metal ions in carbonic anhydrase catalysis.
Nature communications. 11(1) [DOI] 10.1038/s41467-020-18425-5. [PMID] 32917908.
2020
Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells.
European journal of medicinal chemistry. 190 [DOI] 10.1016/j.ejmech.2020.112112. [PMID] 32044580.
2020
Molecular biology and structure of a novel penaeid shrimp densovirus elucidate convergent parvoviral host capsid evolution.
Proceedings of the National Academy of Sciences of the United States of America. 117(33):20211-20222 [DOI] 10.1073/pnas.2008191117. [PMID] 32747554.
2020
Neutron crystallographic studies of carbonic anhydrase.
Methods in enzymology. 634:281-309 [DOI] 10.1016/bs.mie.2020.01.003. [PMID] 32093837.
2020
Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone.
Journal of medicinal chemistry. 63(21):13064-13075 [DOI] 10.1021/acs.jmedchem.0c01390. [PMID] 33085484.
2020
Structural characterization of a bat Adeno-associated virus capsid.
Journal of structural biology. 211(2) [DOI] 10.1016/j.jsb.2020.107547. [PMID] 32522552.
2020
Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology.
Viruses. 12(6) [DOI] 10.3390/v12060653. [PMID] 32560452.
2020
Structural insights into the effect of active-site mutation on the catalytic mechanism of carbonic anhydrase.
IUCrJ. 7(Pt 6):985-994 [DOI] 10.1107/S2052252520011008. [PMID] 33209313.
2020
Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase.
IUCrJ. 7(Pt 2):287-293 [DOI] 10.1107/S2052252520000986. [PMID] 32148856.
2020
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action.
Journal of medicinal chemistry. 63(13):7422-7444 [DOI] 10.1021/acs.jmedchem.0c00733. [PMID] 32519851.
2020
The splicing component ISY1 regulates APE1 in base excision repair.
DNA repair. 86 [DOI] 10.1016/j.dnarep.2019.102769. [PMID] 31887540.
2019
3,17β-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity.
Journal of medicinal chemistry. 62(4):2202-2212 [DOI] 10.1021/acs.jmedchem.8b01990. [PMID] 30721041.
2019
A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells.
The Biochemical journal. 476(10):1497-1513 [DOI] 10.1042/BCJ20190177. [PMID] 31072911.
2019
Adeno-Associated Virus VP1u Exhibits Protease Activity.
Viruses. 11(5) [DOI] 10.3390/v11050399. [PMID] 31035643.
2019
Carbonic anhydrase II in complex with carboxylic acid-based inhibitors.
Acta crystallographica. Section F, Structural biology communications. 75(Pt 3):166-170 [DOI] 10.1107/S2053230X18018344. [PMID] 30839290.
2019
High-Resolution Structural Characterization of a New Adeno-associated Virus Serotype 5 Antibody Epitope toward Engineering Antibody-Resistant Recombinant Gene Delivery Vectors.
Journal of virology. 93(1) [DOI] 10.1128/JVI.01394-18. [PMID] 30333169.
2019
Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70.
The Journal of biological chemistry. 294(2):593-607 [DOI] 10.1074/jbc.RA118.005536. [PMID] 30446621.
2019
Next Generation Sequencing of the Pig αβ TCR Repertoire Identifies the Porcine Invariant NKT Cell Receptor.
Journal of immunology (Baltimore, Md. : 1950). 202(7):1981-1991 [DOI] 10.4049/jimmunol.1801171. [PMID] 30777925.
2019
Pseudomonas aeruginosa β-carbonic anhydrase, psCA1, is required for calcium deposition and contributes to virulence.
Cell calcium. 84 [DOI] 10.1016/j.ceca.2019.102080. [PMID] 31589941.
2019
Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX.
Acta crystallographica. Section D, Structural biology. 75(Pt 10):895-903 [DOI] 10.1107/S2059798319010027. [PMID] 31588921.
2019
Synthesis of saccharin-glycoconjugates targeting carbonic anhydrase using a one-pot cyclization/deprotection strategy.
Carbohydrate research. 476:65-70 [DOI] 10.1016/j.carres.2019.03.001. [PMID] 30921738.
2019
Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative.
Journal of structural biology. 205(2):147-154 [DOI] 10.1016/j.jsb.2018.12.009. [PMID] 30639924.
2018
“Seriously Sweet”: Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.
Journal of medicinal chemistry. 61(3):1176-1181 [DOI] 10.1021/acs.jmedchem.7b01470. [PMID] 29266943.
2018
“To Be or Not to Be” Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation.
Structure (London, England : 1993). 26(3):383-390.e3 [DOI] 10.1016/j.str.2018.01.006. [PMID] 29429876.
2018
4-Hydroxy-3-nitro-5-ureido-benzenesulfonamides Selectively Target the Tumor-Associated Carbonic Anhydrase Isoforms IX and XII Showing Hypoxia-Enhanced Antiproliferative Profiles.
Journal of medicinal chemistry. 61(23):10860-10874 [DOI] 10.1021/acs.jmedchem.8b01504. [PMID] 30433782.
2018
AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognition.
Virology. 518:369-376 [DOI] 10.1016/j.virol.2018.03.007. [PMID] 29604478.
2018
Active-site solvent replenishment observed during human carbonic anhydrase II catalysis.
IUCrJ. 5(Pt 1):93-102 [DOI] 10.1107/S2052252517017626. [PMID] 29354275.
2018
Assembly and disassembly intermediates of maize streak geminivirus.
Virology. 525:224-236 [DOI] 10.1016/j.virol.2018.09.011. [PMID] 30300759.
2018
Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses. 10(1) [DOI] 10.3390/v10010022. [PMID] 29300333.
2018
Atomic structure of a rationally engineered gene delivery vector, AAV2.5.
Journal of structural biology. 203(3):236-241 [DOI] 10.1016/j.jsb.2018.05.004. [PMID] 29775653.
2018
Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors.
International journal of medicinal chemistry. 2018 [DOI] 10.1155/2018/2906519. [PMID] 30112206.
2018
Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site.
Molecules (Basel, Switzerland). 23(5) [DOI] 10.3390/molecules23051045. [PMID] 29710858.
2018
Carbonic anhydrase II does not exhibit Nitrite reductase or Nitrous Anhydrase Activity.
Free radical biology & medicine. 117:1-5 [DOI] 10.1016/j.freeradbiomed.2018.01.015. [PMID] 29355738.
2018
Carbonic anhydrase II microcrystals suitable for XFEL studies.
Acta crystallographica. Section F, Structural biology communications. 74(Pt 6):327-330 [DOI] 10.1107/S2053230X18006118. [PMID] 29870015.
2018
Carbonic Anhydrases: Role in pH Control and Cancer.
Metabolites. 8(1) [DOI] 10.3390/metabo8010019. [PMID] 29495652.
2018
Characterization of a novel variant in siblings with Asparagine Synthetase Deficiency.
Molecular genetics and metabolism. 123(3):317-325 [DOI] 10.1016/j.ymgme.2017.12.433. [PMID] 29279279.
2018
Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function.
Molecular neurobiology. 55(9):7431-7437 [DOI] 10.1007/s12035-017-0854-2. [PMID] 29423818.
2018
Crystal Structure of Cleaved Serp-1, a Myxomavirus-Derived Immune Modulating Serpin: Structural Design of Serpin Reactive Center Loop Peptides with Improved Therapeutic Function.
Biochemistry. 57(7):1096-1107 [DOI] 10.1021/acs.biochem.7b01171. [PMID] 29227673.
2018
Crystallography and Its Impact on Carbonic Anhydrase Research.
International journal of medicinal chemistry. 2018 [DOI] 10.1155/2018/9419521. [PMID] 30302289.
2018
Differential expression and function of CAIX and CAXII in breast cancer: A comparison between tumorgraft models and cells.
PloS one. 13(7) [DOI] 10.1371/journal.pone.0199476. [PMID] 29965974.
2018
Discovery of β-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.
Journal of medicinal chemistry. 61(12):5380-5394 [DOI] 10.1021/acs.jmedchem.8b00625. [PMID] 29851481.
2018
Methods for Determining and Understanding Serpin Structure and Function: X-Ray Crystallography.
Methods in molecular biology (Clifton, N.J.). 1826:9-39 [DOI] 10.1007/978-1-4939-8645-3_2. [PMID] 30194591.
2018
Selective inhibition of carbonic anhydrase IX over carbonic anhydrase XII in breast cancer cells using benzene sulfonamides: Disconnect between activity and growth inhibition.
PloS one. 13(11) [DOI] 10.1371/journal.pone.0207417. [PMID] 30452451.
2018
Short Aβ peptides attenuate Aβ42 toxicity in vivo.
The Journal of experimental medicine. 215(1):283-301 [DOI] 10.1084/jem.20170600. [PMID] 29208777.
2018
Structural Mapping of Anion Inhibitors to β-Carbonic Anhydrase psCA3 from Pseudomonas aeruginosa.
ChemMedChem. 13(19):2024-2029 [DOI] 10.1002/cmdc.201800375. [PMID] 30088334.
2018
Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant.
Nature communications. 9(1) [DOI] 10.1038/s41467-018-06076-6. [PMID] 30194371.
2018
Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose.
ACS medicinal chemistry letters. 9(7):657-661 [DOI] 10.1021/acsmedchemlett.8b00100. [PMID] 30034596.
2018
UFH-001 cells: A novel triple negative, CAIX-positive, human breast cancer model system.
Cancer biology & therapy. 19(7):598-608 [DOI] 10.1080/15384047.2018.1449612. [PMID] 29561695.
2017
Asparagine synthetase: Function, structure, and role in disease.
The Journal of biological chemistry. 292(49):19952-19958 [DOI] 10.1074/jbc.R117.819060. [PMID] 29084849.
2017
Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction.
Viruses. 9(11) [DOI] 10.3390/v9110321. [PMID] 29084163.
2017
Characteristics of candidate genes associated with embryonic development in the cow: Evidence for a role for WBP1 in development to the blastocyst stage.
PloS one. 12(5) [DOI] 10.1371/journal.pone.0178041. [PMID] 28542629.
2017
Discovery of New Sulfonamide Carbonic Anhydrase IX Inhibitors Incorporating Nitrogenous Bases.
ACS medicinal chemistry letters. 8(12):1314-1319 [DOI] 10.1021/acsmedchemlett.7b00399. [PMID] 29259754.
2017
Entropic Anomaly Observed in Lipid Polymorphisms Induced by Surfactant Peptide SP-B(1-25).
The journal of physical chemistry. B. 121(39):9102-9112 [DOI] 10.1021/acs.jpcb.7b06538. [PMID] 28872861.
2017
Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors.
ACS medicinal chemistry letters. 8(9):941-946 [DOI] 10.1021/acsmedchemlett.7b00229. [PMID] 28947941.
2017
Parvovirus Capsid Structures Required for Infection: Mutations Controlling Receptor Recognition and Protease Cleavages.
Journal of virology. 91(2) [DOI] 10.1128/JVI.01871-16. [PMID] 27847360.
2017
Structural Insights into Human Bocaparvoviruses.
Journal of virology. 91(11) [DOI] 10.1128/JVI.00261-17. [PMID] 28331084.
2017
Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides.
European journal of medicinal chemistry. 132:184-191 [DOI] 10.1016/j.ejmech.2017.03.026. [PMID] 28363153.
2017
Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity.
Chembiochem : a European journal of chemical biology. 18(2):213-222 [DOI] 10.1002/cbic.201600513. [PMID] 27860128.
2017
Thermal Stability as a Determinant of AAV Serotype Identity.
Molecular therapy. Methods & clinical development. 6:171-182 [DOI] 10.1016/j.omtm.2017.07.003. [PMID] 28828392.
2016
Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011-2016).
Expert opinion on therapeutic patents. 26(8):947-56 [DOI] 10.1080/13543776.2016.1203904. [PMID] 27387065.
2016
Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site.
Journal of virology. 90(11):5219-5230 [DOI] 10.1128/JVI.00161-16. [PMID] 26962225.
2016
Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
Journal of virology. 90(19):8542-51 [DOI] 10.1128/JVI.00575-16. [PMID] 27440903.
2016
Cryoannealing-induced space-group transition of crystals of the carbonic anhydrase psCA3.
Acta crystallographica. Section F, Structural biology communications. 72(Pt 7):573-7 [DOI] 10.1107/S2053230X16009286. [PMID] 27380376.
2016
Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
The Journal of biological chemistry. 291(43):22741-22756 [PMID] 27576689.
2016
Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies.
Journal of virological methods. 236:105-110 [DOI] 10.1016/j.jviromet.2016.07.009. [PMID] 27424005.
2016
Kinetic and X-ray crystallographic investigations on carbonic anhydrase isoforms I, II, IX and XII of a thioureido analog of SLC-0111.
Bioorganic & medicinal chemistry. 24(5):976-81 [DOI] 10.1016/j.bmc.2016.01.019. [PMID] 26810836.
2016
Mapping Antigenic Epitopes on the Human Bocavirus Capsid.
Journal of virology. 90(9):4670-4680 [DOI] 10.1128/JVI.02998-15. [PMID] 26912619.
2016
Microbatch Mixing: “Shaken Not Stirred”, a Method for Macromolecular Microcrystal Production for Serial Crystallography
Crystal Growth & Design. 16(11):6214-6221 [DOI] 10.1021/acs.cgd.6b00643.
2016
Neutron structure of human carbonic anhydrase II in complex with methazolamide: mapping the solvent and hydrogen-bonding patterns of an effective clinical drug.
IUCrJ. 3(Pt 5):319-325 [DOI] 10.1107/S2052252516010514. [PMID] 28461893.
2016
Non-Classical Inhibition of Carbonic Anhydrase.
International journal of molecular sciences. 17(7) [DOI] 10.3390/ijms17071150. [PMID] 27438828.
2016
Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities.
The Journal of biological chemistry. 291(6):2874-87 [DOI] 10.1074/jbc.M115.704841. [PMID] 26620556.
2016
Solution structure of an “open” E. coli Pol III clamp loader sliding clamp complex.
Journal of structural biology. 194(3):272-81 [DOI] 10.1016/j.jsb.2016.03.003. [PMID] 26968362.
2016
Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.
Bioorganic & medicinal chemistry letters. 26(2):401-405 [DOI] 10.1016/j.bmcl.2015.11.104. [PMID] 26691758.
2016
The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis.
Biochemistry. 55(33):4642-53 [DOI] 10.1021/acs.biochem.6b00243. [PMID] 27439028.
2016
Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals.
Proceedings of the National Academy of Sciences of the United States of America. 113(19):5257-62 [DOI] 10.1073/pnas.1520786113. [PMID] 27114542.
2015
A class of sulfonamide carbonic anhydrase inhibitors with neuropathic pain modulating effects.
Bioorganic & medicinal chemistry. 23(8):1828-40 [DOI] 10.1016/j.bmc.2015.02.027. [PMID] 25766630.
2015
A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.
Acta crystallographica. Section F, Structural biology communications. 71(Pt 10):1352-8 [DOI] 10.1107/S2053230X1501239X. [PMID] 26457530.
2015
Activity and anion inhibition studies of the α-carbonic anhydrase from Thiomicrospira crunogena XCL-2 Gammaproteobacterium.
Bioorganic & medicinal chemistry letters. 25(21):4937-4940 [DOI] 10.1016/j.bmcl.2015.05.001. [PMID] 25998503.
2015
Adeno-associated virus serotype 1 (AAV1)- and AAV5-antibody complex structures reveal evolutionary commonalities in parvovirus antigenic reactivity.
Journal of virology. 89(3):1794-808 [DOI] 10.1128/JVI.02710-14. [PMID] 25410874.
2015
Advances in Anti-Cancer Drug Development Targeting Carbonic Anhydrase IX and XII.
Topics in anti-cancer research. 5:3-42 [PMID] 30272043.
2015
Analysis of the binding moiety mediating the interaction between monocarboxylate transporters and carbonic anhydrase II.
The Journal of biological chemistry. 290(7):4476-86 [DOI] 10.1074/jbc.M114.624577. [PMID] 25561737.
2015
Carbon Dioxide “Trapped” in a β-Carbonic Anhydrase.
Biochemistry. 54(43):6631-8 [DOI] 10.1021/acs.biochem.5b00987. [PMID] 26457866.
2015
Carbonic Anhydrases: Nature’s Way to Balance CO2 Concentration.
Biochemistry & molecular biology journal. 1(1) [DOI] 10.21767/2471-8084.100008. [PMID] 28317035.
2015
Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency.
Biochemistry. 54(2):422-33 [DOI] 10.1021/bi501088e. [PMID] 25513833.
2015
Hypoxia-induced carbonic anhydrase IX facilitates lactate flux in human breast cancer cells by non-catalytic function.
Scientific reports. 5 [DOI] 10.1038/srep13605. [PMID] 26337752.
2015
Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer.
Proceedings of the National Academy of Sciences of the United States of America. 112(18):5673-8 [DOI] 10.1073/pnas.1502255112. [PMID] 25902526.
2015
Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates.
Journal of medicinal chemistry. 58(16):6630-8 [DOI] 10.1021/acs.jmedchem.5b00845. [PMID] 26203869.
2015
Observed surface lysine acetylation of human carbonic anhydrase II expressed in Escherichia coli.
Protein science : a publication of the Protein Society. 24(11):1800-7 [DOI] 10.1002/pro.2771. [PMID] 26266677.
2015
Probing the surface of human carbonic anhydrase for clues towards the design of isoform specific inhibitors.
BioMed research international. 2015 [DOI] 10.1155/2015/453543. [PMID] 25811028.
2015
Saccharin: a lead compound for structure-based drug design of carbonic anhydrase IX inhibitors.
Bioorganic & medicinal chemistry. 23(4):849-54 [DOI] 10.1016/j.bmc.2014.12.030. [PMID] 25614109.
2015
Solution study of the Escherichia coli DNA polymerase III clamp loader reveals the location of the dynamic ψχ heterodimer.
Structural dynamics (Melville, N.Y.). 2(5) [DOI] 10.1063/1.4927407. [PMID] 26798827.
2015
Structural and biophysical characterization of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2: insights into engineering thermostable enzymes for CO2 sequestration.
Acta crystallographica. Section D, Biological crystallography. 71(Pt 8):1745-56 [DOI] 10.1107/S1399004715012183. [PMID] 26249355.
2015
Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II.
The FEBS journal. 282(8):1445-57 [DOI] 10.1111/febs.13232. [PMID] 25683338.
2015
Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.
Bioorganic & medicinal chemistry. 23(15):4831-4838 [DOI] 10.1016/j.bmc.2015.05.029. [PMID] 26068018.
2015
Structure of an enteric pathogen, bovine parvovirus.
Journal of virology. 89(5):2603-14 [DOI] 10.1128/JVI.03157-14. [PMID] 25520501.
2015
Structure of neurotropic adeno-associated virus AAVrh.8.
Journal of structural biology. 192(1):21-36 [DOI] 10.1016/j.jsb.2015.08.017. [PMID] 26334681.
2015
Targeting aggressive cancers with an artificial sweetener: could saccharin be a lead compound in anticancer therapy?
Future oncology (London, England). 11(15):2117-9 [DOI] 10.2217/fon.15.137. [PMID] 26235178.
2015
Targeting carbonic anhydrase IX activity and expression.
Molecules (Basel, Switzerland). 20(2):2323-48 [DOI] 10.3390/molecules20022323. [PMID] 25647573.
2014
A class of 4-sulfamoylphenyl-ω-aminoalkyl ethers with effective carbonic anhydrase inhibitory action and antiglaucoma effects.
Journal of medicinal chemistry. 57(22):9673-86 [DOI] 10.1021/jm501497m. [PMID] 25358036.
2014
Adeno-associated virus capsid proteins may play a role in transcription and second-strand synthesis of recombinant genomes.
Journal of virology. 88(2):1071-9 [DOI] 10.1128/JVI.02093-13. [PMID] 24198419.
2014
Amiloride inhibits the initiation of Coxsackievirus and poliovirus RNA replication by inhibiting VPg uridylylation.
Virology. 464-465:87-97 [DOI] 10.1016/j.virol.2014.06.025. [PMID] 25058507.
2014
An intramolecular lock facilitates folding and stabilizes the tertiary structure of Streptococcus mutans adhesin P1.
Proceedings of the National Academy of Sciences of the United States of America. 111(44):15746-51 [DOI] 10.1073/pnas.1413018111. [PMID] 25331888.
2014
Carbonic Anhydrase Inhibition with Benzenesulfonamides and Tetrafluorobenzenesulfonamides Obtained via Click Chemistry.
ACS medicinal chemistry letters. 5(8):927-30 [DOI] 10.1021/ml500196t. [PMID] 25147616.
2014
Carbonic anhydrase inhibitors drug design.
Sub-cellular biochemistry. 75:291-323 [DOI] 10.1007/978-94-007-7359-2_15. [PMID] 24146385.
2014
Carbonic Anhydrases Facilitate Proton-Driven Lactate Transport Via Direct Interaction
Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire. 92(6)
2014
Catalytic mechanism of α-class carbonic anhydrases: CO2 hydration and proton transfer.
Sub-cellular biochemistry. 75:31-52 [DOI] 10.1007/978-94-007-7359-2_3. [PMID] 24146373.
2014
EBV-positive mucocutaneous ulcer in organ transplant recipients: a localized indolent posttransplant lymphoproliferative disorder.
The American journal of surgical pathology. 38(11):1522-9 [DOI] 10.1097/PAS.0000000000000282. [PMID] 25007145.
2014
Human carbonic anhydrase II-cyanate inhibitor complex: putting the debate to rest.
Acta crystallographica. Section F, Structural biology communications. 70(Pt 10):1324-7 [DOI] 10.1107/S2053230X14018135. [PMID] 25286933.
2014
Hypoxia-Induced Carbonic Anhydrase Ix Enhances Lactate Transport in Human Breast Cancer Cells By a Non-Catalytic Mechanism
Acta Physiologica. 210(695)
2014
Induction of the intrinsic apoptotic pathway via a new antimitotic agent in an esophageal carcinoma cell line.
Cell & bioscience. 4 [DOI] 10.1186/2045-3701-4-68. [PMID] 25937890.
2014
Novel estradiol analogue induces apoptosis and autophagy in esophageal carcinoma cells.
Cellular & molecular biology letters. 19(1):98-115 [DOI] 10.2478/s11658-014-0183-7. [PMID] 24563014.
2014
Overview of the carbonic anhydrase family.
Sub-cellular biochemistry. 75:3-5 [DOI] 10.1007/978-94-007-7359-2_1. [PMID] 24146371.
2014
Preliminary X-ray crystallographic analysis of glutathione transferase zeta 1 (GSTZ1a-1a).
Acta crystallographica. Section F, Structural biology communications. 70(Pt 2):187-9 [DOI] 10.1107/S2053230X13033591. [PMID] 24637752.
2014
Profiling of glycan receptors for minute virus of mice in permissive cell lines towards understanding the mechanism of cell recognition.
PloS one. 9(1) [DOI] 10.1371/journal.pone.0086909. [PMID] 24475195.
2014
Structural elucidation of the hormonal inhibition mechanism of the bile acid cholate on human carbonic anhydrase II.
Acta crystallographica. Section D, Biological crystallography. 70(Pt 6):1758-63 [DOI] 10.1107/S1399004714007457. [PMID] 24914985.
2014
Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles.
IUCrJ. 1(Pt 2):129-35 [DOI] 10.1107/S2052252514004096. [PMID] 25075329.
2014
Structural insights into carbonic anhydrase IX isoform specificity of carbohydrate-based sulfamates.
Journal of medicinal chemistry. 57(20):8635-45 [DOI] 10.1021/jm5012935. [PMID] 25254302.
2014
The role of select subtype polymorphisms on HIV-1 protease conformational sampling and dynamics.
The Journal of biological chemistry. 289(24):17203-14 [DOI] 10.1074/jbc.M114.571836. [PMID] 24742668.
2014
The structure of AAVrh32.33, a novel gene delivery vector.
Journal of structural biology. 186(2):308-17 [DOI] 10.1016/j.jsb.2014.03.020. [PMID] 24704217.
2014
Uric acid inhibition of dipeptidyl peptidase IV in vitro is dependent on the intracellular formation of triuret.
Experimental cell research. 326(1):136-42 [DOI] 10.1016/j.yexcr.2014.05.025. [PMID] 24925478.
2013
Anticonvulsant/antiepileptic carbonic anhydrase inhibitors: a patent review.
Expert opinion on therapeutic patents. 23(6):717-24 [DOI] 10.1517/13543776.2013.782394. [PMID] 23514045.
2013
Biochemical and biophysical properties of a putative hub protein expressed by vaccinia virus.
The Journal of biological chemistry. 288(16):11470-81 [DOI] 10.1074/jbc.M112.442012. [PMID] 23476017.
2013
Capsid antibodies to different adeno-associated virus serotypes bind common regions.
Journal of virology. 87(16):9111-24 [DOI] 10.1128/JVI.00622-13. [PMID] 23760240.
2013
Carbonic Anhydrase II Enhances Activity of Monocarboxylate Transporters Via Direct Interaction
European Biophysics Journal With Biophysics Letters. 42(1)
2013
Carbonic anhydrases and their biotechnological applications.
Biomolecules. 3(3):553-62 [DOI] 10.3390/biom3030553. [PMID] 24970180.
2013
Comparative analysis of adeno-associated virus capsid stability and dynamics.
Journal of virology. 87(24):13150-60 [DOI] 10.1128/JVI.01415-13. [PMID] 24067976.
2013
Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.
Bioorganic & medicinal chemistry letters. 23(20):5646-9 [DOI] 10.1016/j.bmcl.2013.08.019. [PMID] 23993330.
2013
Effects of cryoprotectants on the structure and thermostability of the human carbonic anhydrase II-acetazolamide complex.
Acta crystallographica. Section D, Biological crystallography. 69(Pt 5):860-5 [DOI] 10.1107/S0907444913002771. [PMID] 23633596.
2013
Insights towards sulfonamide drug specificity in α-carbonic anhydrases.
Bioorganic & medicinal chemistry. 21(6):1526-33 [DOI] 10.1016/j.bmc.2012.08.019. [PMID] 22985956.
2013
Preliminary X-ray crystallographic analysis of β-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.
Acta crystallographica. Section F, Structural biology and crystallization communications. 69(Pt 8):891-4 [DOI] 10.1107/S1744309113017594. [PMID] 23908036.
2013
Role of Trp19 and Tyr200 in catalysis by the γ-class carbonic anhydrase from Methanosarcina thermophila.
Archives of biochemistry and biophysics. 529(1):11-7 [DOI] 10.1016/j.abb.2012.10.010. [PMID] 23111186.
2013
Signaling pathways of ESE-16, an antimitotic and anticarbonic anhydrase estradiol analog, in breast cancer cells.
PloS one. 8(1) [DOI] 10.1371/journal.pone.0053853. [PMID] 23382857.
2013
Structural and catalytic characterization of a thermally stable and acid-stable variant of human carbonic anhydrase II containing an engineered disulfide bond.
Acta crystallographica. Section D, Biological crystallography. 69(Pt 8):1414-22 [DOI] 10.1107/S0907444913008743. [PMID] 23897465.
2013
Structural annotation of human carbonic anhydrases.
Journal of enzyme inhibition and medicinal chemistry. 28(2):267-77 [DOI] 10.3109/14756366.2012.737323. [PMID] 23137351.
2013
Structural characterization of H-1 parvovirus: comparison of infectious virions to empty capsids.
Journal of virology. 87(9):5128-40 [DOI] 10.1128/JVI.03416-12. [PMID] 23449783.
2013
Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.
Bioorganic & medicinal chemistry. 21(8):2314-2318 [DOI] 10.1016/j.bmc.2013.02.022. [PMID] 23490152.
2013
Structural insights into adeno-associated virus serotype 5.
Journal of virology. 87(20):11187-99 [DOI] 10.1128/JVI.00867-13. [PMID] 23926356.
2013
Structural study of interaction between brinzolamide and dorzolamide inhibition of human carbonic anhydrases.
Bioorganic & medicinal chemistry. 21(22):7210-5 [DOI] 10.1016/j.bmc.2013.08.033. [PMID] 24090602.
2013
Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition.
Bioorganic & medicinal chemistry. 21(21):6674-80 [DOI] 10.1016/j.bmc.2013.08.011. [PMID] 24012377.
2013
Structural, catalytic and stabilizing consequences of aromatic cluster variants in human carbonic anhydrase II.
Archives of biochemistry and biophysics. 539(1):31-7 [DOI] 10.1016/j.abb.2013.09.001. [PMID] 24036123.
2013
Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking.
Journal of virology. 87(9):4974-84 [DOI] 10.1128/JVI.02524-12. [PMID] 23427155.
2013
The Malignant Brain Tumor (Mbt) Domain Protein Sfmbt1 Is An Integral Histone Reader Subunit of the Lsd1 Demethylase Complex for Chromatin Association and Epithelial-To-Mesenchymal Transition
Journal of Biological Chemistry. 288(38):27680-27691 [DOI] 10.1074/jbc.M113.482349. [PMID] 23928305.
2013
The Structure of Aavrh32.33, a Novel Gene Delivery Vector
Molecular Therapy. 21
2013
Water networks in fast proton transfer during catalysis by human carbonic anhydrase II.
Biochemistry. 52(1):125-31 [DOI] 10.1021/bi301099k. [PMID] 23215152.
2012
Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo.
Journal of medicinal chemistry. 55(4):1721-30 [DOI] 10.1021/jm300031j. [PMID] 22276570.
2012
Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations.
Chemical communications (Cambridge, England). 48(13):1868-70 [DOI] 10.1039/c2cc16395k. [PMID] 22218610.
2012
Evidence for pH-dependent protease activity in the adeno-associated virus capsid.
Journal of virology. 86(21):11877-85 [DOI] 10.1128/JVI.01717-12. [PMID] 22915820.
2012
In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity.
PloS one. 7(12) [DOI] 10.1371/journal.pone.0052205. [PMID] 23300615.
2012
Kinetic and structural characterization of thermostabilized mutants of human carbonic anhydrase II.
Protein engineering, design & selection : PEDS. 25(7):347-55 [DOI] 10.1093/protein/gzs027. [PMID] 22691706.
2012
Lactate flux in astrocytes is enhanced by a non-catalytic action of carbonic anhydrase II.
The Journal of physiology. 590(10):2333-51 [DOI] 10.1113/jphysiol.2011.220152. [PMID] 22451434.
2012
Mapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8.
Journal of virology. 86(15):7739-51 [DOI] 10.1128/JVI.00218-12. [PMID] 22593150.
2012
Mining the protein data bank to differentiate error from structural variation in clustered static structures: an examination of HIV protease.
Viruses. 4(3):348-62 [DOI] 10.3390/v4030348. [PMID] 22590675.
2012
Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding.
Journal of the American Chemical Society. 134(36):14726-9 [DOI] 10.1021/ja3068098. [PMID] 22928733.
2012
Preliminary X-ray crystallographic analysis of α-carbonic anhydrase from Thiomicrospira crunogena XCL-2.
Acta crystallographica. Section F, Structural biology and crystallization communications. 68(Pt 9):1064-6 [DOI] 10.1107/S1744309112031053. [PMID] 22949195.
2012
Production, purification, crystallization and structure determination of H-1 Parvovirus.
Acta crystallographica. Section F, Structural biology and crystallization communications. 68(Pt 12):1571-6 [DOI] 10.1107/S1744309112045563. [PMID] 23192051.
2012
Role of zinc in catalytic activity of carbonic anhydrase IX.
Archives of biochemistry and biophysics. 521(1-2):90-4 [DOI] 10.1016/j.abb.2012.03.017. [PMID] 22465027.
2012
Structural and kinetic effects on changes in the CO(2) binding pocket of human carbonic anhydrase II.
Biochemistry. 51(45):9156-63 [DOI] 10.1021/bi301155z. [PMID] 23098192.
2012
Structural insight into the unique properties of adeno-associated virus serotype 9.
Journal of virology. 86(12):6947-58 [DOI] 10.1128/JVI.07232-11. [PMID] 22496238.
2012
The 3D Structure of Adeno-Associated Virus Serotype 9 and Its Unique Properties
Molecular Therapy. 20
2012
Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.
Journal of medicinal chemistry. 55(22):9619-29 [DOI] 10.1021/jm300878g. [PMID] 23067387.
2012
Update on carbonic anhydrase inhibitors: a patent review (2008 – 2011).
Expert opinion on therapeutic patents. 22(8):903-15 [DOI] 10.1517/13543776.2012.707646. [PMID] 22788994.
2011
A Nonenzymatic Transport Metabolon Enhances Lactate Flux in Astrocytes
Glia. 59
2011
Anticonvulsant 4-aminobenzenesulfonamide derivatives with branched-alkylamide moieties: X-ray crystallography and inhibition studies of human carbonic anhydrase isoforms I, II, VII, and XIV.
Journal of medicinal chemistry. 54(11):3977-81 [DOI] 10.1021/jm200209n. [PMID] 21506569.
2011
Characterization of Carbonic Anhydrase Isozyme Specific Inhibition By Sulfamated 2-Ethylestra Compounds
Letters in Drug Design & Discovery. 8:678-684
2011
Chemical rescue of enzymes: proton transfer in mutants of human carbonic anhydrase II.
Journal of the American Chemical Society. 133(16):6223-34 [DOI] 10.1021/ja1097594. [PMID] 21452838.
2011
Confirmation of the severe phenotypic effect of serine at codon 41 of the superoxide dismutase 1 gene.
Muscle & nerve. 44(4):499-502 [DOI] 10.1002/mus.22117. [PMID] 21755517.
2011
Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.
Bioorganic & medicinal chemistry. 19(12):3732-8 [DOI] 10.1016/j.bmc.2011.05.006. [PMID] 21620713.
2011
Insights into Mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein.
Proteins. 79(2):528-36 [DOI] 10.1002/prot.22900. [PMID] 21117240.
2011
Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II.
Proceedings of the National Academy of Sciences of the United States of America. 108(7):3071-6 [DOI] 10.1073/pnas.1014293108. [PMID] 21282642.
2011
Kinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase II.
Archives of biochemistry and biophysics. 506(2):181-7 [DOI] 10.1016/j.abb.2010.12.004. [PMID] 21145876.
2011
Neutron structure of human carbonic anhydrase II: a hydrogen-bonded water network “switch” is observed between pH 7.8 and 10.0.
Biochemistry. 50(44):9421-3 [DOI] 10.1021/bi201487b. [PMID] 21988105.
2011
Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.
Journal of virology. 85(22):11791-9 [DOI] 10.1128/JVI.05305-11. [PMID] 21900159.
2011
Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5.
Archives of biochemistry and biophysics. 516(2):97-102 [DOI] 10.1016/j.abb.2011.09.011. [PMID] 22001224.
2011
Substrate-dependent interference of carbonic anhydrases with the glutamine transporter SNAT3-induced conductance.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 27(1):79-90 [DOI] 10.1159/000325208. [PMID] 21325825.
2011
Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.
Bioorganic & medicinal chemistry. 19(10):3105-19 [DOI] 10.1016/j.bmc.2011.04.005. [PMID] 21515057.
2011
The Escherichia coli clamp loader can actively pry open the β-sliding clamp.
The Journal of biological chemistry. 286(49):42704-42714 [DOI] 10.1074/jbc.M111.268169. [PMID] 21971175.
2011
Transport Activity of the Electrogenic Sodium-Bicarbonate Cotransporter Nbce1 Is Increased By a Functional Interaction With Carbonic Anhydrase Isoforms I, Ii, and III
Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire. 89:275-276
2011
Transport activity of the sodium bicarbonate cotransporter NBCe1 is enhanced by different isoforms of carbonic anhydrase.
PloS one. 6(11) [DOI] 10.1371/journal.pone.0027167. [PMID] 22076132.
2010
A short, strong hydrogen bond in the active site of human carbonic anhydrase II.
Biochemistry. 49(2):249-51 [DOI] 10.1021/bi902007b. [PMID] 20000378.
2010
Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.
Bioorganic & medicinal chemistry letters. 20(15):4376-81 [DOI] 10.1016/j.bmcl.2010.06.082. [PMID] 20605094.
2010
Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II.
Archives of biochemistry and biophysics. 502(1):53-9 [DOI] 10.1016/j.abb.2010.07.010. [PMID] 20637176.
2010
Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.
Bioorganic & medicinal chemistry. 18(14):4873-8 [DOI] 10.1016/j.bmc.2010.06.028. [PMID] 20598552.
2010
Emerging from pseudo-symmetry: the redetermination of human carbonic anhydrase II in monoclinic P2(1) with a doubled a axis.
Acta crystallographica. Section D, Biological crystallography. 66(Pt 8):950-2 [DOI] 10.1107/S0907444910023723. [PMID] 20693695.
2010
Enzymes for carbon sequestration: neutron crystallographic studies of carbonic anhydrase.
Acta crystallographica. Section D, Biological crystallography. 66(Pt 11):1178-83 [DOI] 10.1107/S0907444910019700. [PMID] 21041933.
2010
Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae.
Journal of virology. 84(12):5880-9 [DOI] 10.1128/JVI.02719-09. [PMID] 20375175.
2010
Neutron structure of human carbonic anhydrase II: implications for proton transfer.
Biochemistry. 49(3):415-21 [DOI] 10.1021/bi901995n. [PMID] 20025241.
2010
Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.
Chemical communications (Cambridge, England). 46(44):8371-3 [DOI] 10.1039/c0cc02707c. [PMID] 20922253.
2010
Sequestration of carbon dioxide by the hydrophobic pocket of the carbonic anhydrases.
Biochimica et biophysica acta. 1804(2):326-31 [DOI] 10.1016/j.bbapap.2009.07.025. [PMID] 19679198.
2010
Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
Biochemistry. 49(30):6394-9 [DOI] 10.1021/bi1007645. [PMID] 20578724.
2010
Structural characterization of the dual glycan binding adeno-associated virus serotype 6.
Journal of virology. 84(24):12945-57 [DOI] 10.1128/JVI.01235-10. [PMID] 20861247.
2010
Structure of a monoclinic polymorph of human carbonic anhydrase II with a doubled a axis.
Acta crystallographica. Section D, Biological crystallography. 66(Pt 5):628-34 [DOI] 10.1107/S0907444910006797. [PMID] 20445238.
2010
Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes.
Acta crystallographica. Section D, Biological crystallography. 66(Pt 3):233-42 [DOI] 10.1107/S0907444909054298. [PMID] 20179334.
2010
Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II.
The journal of physical chemistry letters. 1(19):2898-2902 [PMID] 20976122.
2009
Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network.
Biochemistry. 48(31):7365-72 [DOI] 10.1021/bi9007512. [PMID] 19583303.
2009
Cloning, expression, purification, crystallization and preliminary X-ray analysis of Mycoplasma genitalium protein MG289.
Acta crystallographica. Section F, Structural biology and crystallization communications. 65(Pt 9):910-2 [DOI] 10.1107/S1744309109030565. [PMID] 19724130.
2009
Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank.
Acta crystallographica. Section D, Biological crystallography. 65(Pt 3):294-6 [DOI] 10.1107/S0907444908041632. [PMID] 19237752.
2009
Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.
Biochemistry. 48(6):1322-31 [DOI] 10.1021/bi802035f. [PMID] 19170619.
2009
Effect of active-site mutation at Asn67 on the proton transfer mechanism of human carbonic anhydrase II.
Biochemistry. 48(33):7996-8005 [DOI] 10.1021/bi901037u. [PMID] 19634894.
2009
Elucidation of the proton transport mechanism in human carbonic anhydrase II.
Journal of the American Chemical Society. 131(22):7598-608 [DOI] 10.1021/ja8091938. [PMID] 19438233.
2009
Heparin binding induces conformational changes in Adeno-associated virus serotype 2.
Journal of structural biology. 165(3):146-56 [DOI] 10.1016/j.jsb.2008.12.002. [PMID] 19121398.
2009
High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design.
Acta crystallographica. Section F, Structural biology and crystallization communications. 65(Pt 10):992-5 [DOI] 10.1107/S1744309109036665. [PMID] 19851004.
2009
Plasmepsin 9 as a New Target for Antimalarial Drug Discovery
Biopolymers. 92
2009
Preliminary joint neutron and X-ray crystallographic study of human carbonic anhydrase II.
Acta crystallographica. Section F, Structural biology and crystallization communications. 65(Pt 5):495-8 [DOI] 10.1107/S1744309109013086. [PMID] 19407386.
2009
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9.
Acta crystallographica. Section F, Structural biology and crystallization communications. 65(Pt 7):715-8 [DOI] 10.1107/S1744309109021460. [PMID] 19574648.
2009
Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis.
Biochemistry. 48(19):4086-99 [DOI] 10.1021/bi802059r. [PMID] 19271776.
2009
Structural insights into the extracytoplasmic thiamine-binding lipoprotein p37 of Mycoplasma hyorhinis.
Journal of bacteriology. 191(8):2585-92 [DOI] 10.1128/JB.01680-08. [PMID] 19233924.
2009
Structural Studies of Adeno-Associated Virus Serotypes Towards Improved Gene Therapy Applications
Molecular Therapy. 17
2009
Structural Studies of Autonomous Parvovirus Capsids and Their Glycan Interactions Towards Understanding Their Mechanisms of Cell Recognition and Pathogenicity
Glycobiology. 19
2009
Towards Characterizing Vector-Host Interactions: Adeno-Associated Virus Capsids in Complex With Antibody Fragments
Molecular Therapy. 17
2008
A Comparative Analysis of the Structural Architecture of Ssdna Viruses
Computational and Mathematical Methods in Medicine. 9(34):183-196 [DOI] 10.1080/17486700802168247.
2008
Assembly and structural analysis of a covalently closed nano-scale DNA cage.
Nucleic acids research. 36(4):1113-9 [PMID] 18096620.
2008
Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation.
Journal of medicinal chemistry. 51(4):852-60 [DOI] 10.1021/jm701170f. [PMID] 18215016.
2008
Entrapment of carbon dioxide in the active site of carbonic anhydrase II.
The Journal of biological chemistry. 283(45):30766-71 [DOI] 10.1074/jbc.M805353200. [PMID] 18768466.
2008
Genomic evolution in a virus under specific selection for host recognition.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 8(6):825-34 [DOI] 10.1016/j.meegid.2008.08.008. [PMID] 18804189.
2008
High-resolution structure of unbound human immunodeficiency virus 1 subtype C protease: implications of flap dynamics and drug resistance.
Acta crystallographica. Section D, Biological crystallography. D64(Pt 7):754-63 [DOI] 10.1107/S090744490801278X. [PMID] 18566511.
2008
Immunophenotypic studies of monoclonal gammopathy of undetermined significance.
BMC clinical pathology. 8 [DOI] 10.1186/1472-6890-8-13. [PMID] 19040735.
2008
Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.
Biochemistry. 47(10):3174-84 [DOI] 10.1021/bi702385k. [PMID] 18266323.
2008
Origins of enhanced proton transport in the Y7F mutant of human carbonic anhydrase II.
Journal of the American Chemical Society. 130(34):11399-408 [DOI] 10.1021/ja802264j. [PMID] 18671353.
2008
Pres 30-Locating the Vp1 Structural Protein in Adeno-Associated Viruses
. 235
2008
Pres 33-Ph Induced Conformational Changes On the Surface of the Aav1 Capsid: Implications for Capsid Trafficking and Uncoating
. 235
2008
Role of a glutamate bridge spanning the dimeric interface of human manganese superoxide dismutase.
Biochemistry. 47(16):4621-8 [DOI] 10.1021/bi7024518. [PMID] 18373354.
2008
Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.
Biochemistry. 47(46):12028-36 [DOI] 10.1021/bi801473w. [PMID] 18942852.
2008
Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37.
Acta crystallographica. Section D, Biological crystallography. 64(Pt 11):1172-8 [DOI] 10.1107/S0907444908030175. [PMID] 19020356.
2008
The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease.
Biochemistry. 47(2):731-43 [PMID] 18092815.
2007
Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism.
Biochemistry. 46(11):2930-7 [PMID] 17319692.
2007
Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol.
Journal of molecular endocrinology. 39(4):223-37 [PMID] 17909263.
2007
Expression, purification and preliminary X-ray crystallographic studies of the human immunodeficiency virus 1 subtype C protease.
Acta crystallographica. Section F, Structural biology and crystallization communications. 63(Pt 4):320-3 [PMID] 17401206.
2007
Location of binding sites in small molecule rescue of human carbonic anhydrase II.
Biophysical journal. 92(2):562-70 [PMID] 17071654.
2007
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7.
Acta crystallographica. Section F, Structural biology and crystallization communications. 63(Pt 12):1073-6 [PMID] 18084098.
2007
Sex, depression, and risk of hospitalization and mortality in chronic obstructive pulmonary disease.
Archives of internal medicine. 167(21):2345-53 [PMID] 18039994.
2007
Solvent-mediated proton transfer in catalysis by carbonic anhydrase.
Accounts of chemical research. 40(8):669-75 [PMID] 17550224.
2007
Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II.
Biochemistry. 46(12):3803-13 [PMID] 17330962.
2007
Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma: a single institution experience.
American journal of clinical pathology. 127(1):39-46 [PMID] 17145625.
2007
Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.
Proteins. 68(1):337-43 [PMID] 17427958.
2007
Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases.
Biochemistry. 46(51):14830-7 [PMID] 18044968.
2007
Structure of adeno-associated virus serotype 8, a gene therapy vector.
Journal of virology. 81(22):12260-71 [PMID] 17728238.
2006
Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.
Biochemistry. 45(17):5468-77 [PMID] 16634628.
2006
Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation.
Free radical biology & medicine. 40(3):453-8 [PMID] 16443160.
2006
Expression, purification, kinetic, and structural characterization of an alpha-class carbonic anhydrase from Aedes aegypti (AaCA1).
Biochimica et biophysica acta. 1764(8):1413-9 [PMID] 16920039.
2006
Flow cytometric features of angioimmunoblastic T-cell lymphoma.
Cytometry. Part B, Clinical cytometry. 70(3):142-8 [PMID] 16572417.
2006
Host-selected amino acid changes at the sialic acid binding pocket of the parvovirus capsid modulate cell binding affinity and determine virulence.
Journal of virology. 80(3):1563-73 [PMID] 16415031.
2006
Identification of the sialic acid structures recognized by minute virus of mice and the role of binding affinity in virulence adaptation.
The Journal of biological chemistry. 281(35):25670-7 [PMID] 16822863.
2006
Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 1):6-9 [PMID] 16511248.
2006
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 1.
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 12):1271-4 [PMID] 17142915.
2006
Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.
Journal of virology. 80(23):11556-70 [PMID] 16971437.
2006
Structure of human salivary alpha-amylase crystallized in a C-centered monoclinic space group.
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 2):88-93 [PMID] 16511271.
2006
Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.
Acta crystallographica. Section D, Biological crystallography. 62(Pt 3):246-52 [PMID] 16510971.
2006
X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 7):618-22 [PMID] 16820676.
2005
Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries.
Biochemistry. 44(6):1768-79 [PMID] 15697202.
2005
Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae.
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 2):228-31 [PMID] 16511002.
2005
Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer.
Biochemistry. 44(30):10046-53 [PMID] 16042381.
2005
p37 Induces tumor invasiveness.
Molecular cancer therapeutics. 4(7):1031-8 [PMID] 16020660.
2005
Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8.
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 6):558-61 [PMID] 16511095.
2005
Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5.
Acta crystallographica. Section F, Structural biology and crystallization communications. 61(Pt 10):917-21 [PMID] 16511195.
2005
Proton transfer from exogenous donors in catalysis by human carbonic anhydrase II.
Archives of biochemistry and biophysics. 437(1):106-14 [PMID] 15820222.
2005
Proton transfer in a Thr200His mutant of human carbonic anhydrase II.
Proteins. 61(2):239-45 [PMID] 16106378.
2005
Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.
Biochemistry. 44(4):1097-105 [PMID] 15667203.
2005
Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice.
Journal of virology. 79(17):10931-43 [PMID] 16103145.
2005
Structure of adeno-associated virus type 4.
Journal of virology. 79(8):5047-58 [PMID] 15795290.
2004
Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer.
Journal of structural biology. 146(3):291-301 [PMID] 15099571.
2004
Characterization of incidentally identified minute clonal B-lymphocyte populations in peripheral blood and bone marrow.
American journal of clinical pathology. 122(4):588-95 [PMID] 15487458.
2004
Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.
Biochemistry. 43(38):12141-51 [PMID] 15379553.
2004
Crystallization and preliminary X-ray crystallographic studies on recombinant rat choline acetyltransferase.
Acta crystallographica. Section D, Biological crystallography. 60(Pt 2):374-5 [PMID] 14747730.
2004
Isolation and characterization of subgenomic DNAs encapsidated in “single” T = 1 isometric particles of Maize streak virus.
Virology. 323(1):164-71 [PMID] 15165828.
2004
Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase.
Journal of structural biology. 146(3):416-24 [PMID] 15099582.
2004
Structural determination of a partially hemihedrally twinned actin crystal.
Acta crystallographica. Section D, Biological crystallography. 60(Pt 6):1040-7 [PMID] 15159563.
2004
Structural insights and functional implications of choline acetyltransferase.
Journal of structural biology. 148(2):226-35 [PMID] 15477102.
2003
Molecular modeling of the rabbit colonic (HKalpha2a) H+, K+ ATPase.
Journal of molecular modeling. 9(5):283-9 [PMID] 12884085.
2003
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 4.
Virology. 306(1):1-6 [PMID] 12620791.
2003
Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer.
The Journal of biological chemistry. 278(15):13159-65 [PMID] 12562770.
2003
The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer.
Acta crystallographica. Section D, Biological crystallography. 59(Pt 1):93-104 [PMID] 12499545.
2002
Chemical rescue in catalysis by human carbonic anhydrases II and III.
Biochemistry. 41(9):3235-42 [PMID] 11863462.
2002
Crystallization and preliminary X-ray analysis of human carbonic anhydrase III.
Acta crystallographica. Section D, Biological crystallography. 58(Pt 5):849-52 [PMID] 11976500.
2002
Crystallization and preliminary X-ray analysis of the tumor metastasis factor p37.
Acta crystallographica. Section D, Biological crystallography. 58(Pt 12):2141-4 [PMID] 12454480.
2002
Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase.
Acta crystallographica. Section D, Biological crystallography. 58(Pt 7):1193-4 [PMID] 12077440.
2002
Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase.
The Journal of biological chemistry. 277(41):38870-6 [PMID] 12171926.
2002
Microviridae, a family divided: isolation, characterization, and genome sequence of phiMH2K, a bacteriophage of the obligate intracellular parasitic bacterium Bdellovibrio bacteriovorus.
Journal of bacteriology. 184(4):1089-94 [PMID] 11807069.
2002
Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution.
The Journal of biological chemistry. 277(23):20999-1006 [PMID] 11932258.
2001
Identification of aleutian mink disease parvovirus capsid sequences mediating antibody-dependent enhancement of infection, virus neutralization, and immune complex formation.
Journal of virology. 75(22):11116-27 [PMID] 11602751.
2001
Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II.
Biochemistry. 40(6):1741-8 [PMID] 11327835.
2001
Structure of the Maize streak virus geminate particle.
Virology. 279(2):471-7 [PMID] 11162803.
2000
A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling.
Proceedings of the National Academy of Sciences of the United States of America. 97(17):9476-81 [PMID] 10920199.
2000
Biochemical and physical characterization of parvovirus minute virus of mice virus-like particles.
Virology. 267(2):299-309 [PMID] 10662625.
1999
Three-dimensional structure of Aleutian mink disease parvovirus: implications for disease pathogenicity.
Journal of virology. 73(8):6882-91 [PMID] 10400786.
1998
Structural analysis of the Spiroplasma virus, SpV4: implications for evolutionary variation to obtain host diversity among the Microviridae.
Structure (London, England : 1993). 6(2):135-45 [PMID] 9519405.
1998
Structure determination of the phiX174 closed procapsid.
Acta crystallographica. Section D, Biological crystallography. 54(Pt 5):878-90 [PMID] 9757104.
1997
Structure of a viral procapsid with molecular scaffolding.
Nature. 389(6648):308-13 [PMID] 9305849.
1996
Atomic structure of the degraded procapsid particle of the bacteriophage G4: induced structural changes in the presence of calcium ions and functional implications.
Journal of molecular biology. 256(4):736-50 [PMID] 8642594.
1995
DNA packaging intermediates of bacteriophage φX174.
Structure (London, England : 1993). 3(4):353-363 [PMID] 7613866.
1994
Analysis of the single-stranded DNA bacteriophage phi X174, refined at a resolution of 3.0 A.
Journal of molecular biology. 237(5):517-43 [PMID] 8158636.
1994
Calcium ion-induced structural changes in bacteriophage phi X174.
Journal of molecular biology. 244(3):291-300 [PMID] 7966340.
1994
The structure of human parvovirus B19 at 8 A resolution.
Virology. 203(1):106-15 [PMID] 8030266.
1993
Structure determination of feline panleukopenia virus empty particles.
Proteins. 16(2):155-71 [PMID] 8392729.
1992
Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives.
Journal of medicinal chemistry. 35(8):1418-29 [PMID] 1573635.
1992
Atomic structure of single-stranded DNA bacteriophage phi X174 and its functional implications.
Nature. 355(6356):137-43 [PMID] 1370343.
1991
Assuring continued competence. Is recertification the way?
American journal of clinical pathology. 96(2):267-72 [PMID] 1677797.
1991
Preliminary X-ray crystallographic investigation of human parvovirus B19.
Virology. 184(1):170-4 [PMID] 1871964.
1990
Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.
Journal of medicinal chemistry. 33(9):2673-9 [PMID] 2391706.
1990
Preliminary investigation of the phage phi X174 crystal structure.
Journal of molecular biology. 212(2):345-50 [PMID] 2138678.
1988
Structures of the anticancer compounds N-(2-hydroxyethyl)-2-(3-nitro-1,2,4-triazol-1-yl)-acetamide (RB-6110) and 5-(1-aziridinyl)-3-nitro-1-(3-oxo-1-butyl)-1,2,4- triazole (RB-6162).
Acta crystallographica. Section B, Structural science. 44 ( Pt 6):672-6 [PMID] 3271560.
1976
Extended field radiotherapy in non-Hodgkin’s lymphoma.
Radiology. 118(2):457-9 [PMID] 943123.

Grants

Nov 2022 ACTIVE
A study into the expression of TTV and its possible development as a gene therapy vector
Role: Principal Investigator
Funding: INTIMA BIOSCIENCE
Feb 2022 – Jul 2022
Cryo-EM analysis of AAV capsid full/empty ratio determinations
Role: Principal Investigator
Funding: STRIDEBIO
Jan 2022 ACTIVE
RNA virus capture of host chemokines: Understanding novel viral mechanisms of immune manipulation
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Dec 2021 – Jan 2022
Generation of AAV1 VP3-only DNA empty capsids
Role: Principal Investigator
Funding: THERMO FINNIGAN
Aug 2021 – Oct 2021
Generation of AAV1 VP3 only DNA empty capsids
Role: Principal Investigator
Funding: THERMO FINNIGAN
Jun 2020 – May 2022
Adverum Task Order #2 – Structure determination of AAV variants and 3D homology model building
Role: Principal Investigator
Funding: ADVERUM BIOTECHNOLOGIES INC
Apr 2020 ACTIVE
Correlative structure and function studies of adeno-associated virus particles during viral genome release
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Mar 2020 ACTIVE
Asparagine Synthetase Deficiency
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Dec 2019 ACTIVE
AAV capsids and their cellular interactions
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
May 2019 ACTIVE
Anti-viral Mechanisms of Defensins
Role: Principal Investigator
Funding: UNIV OF WASHINGTON via NATL INST OF HLTH NIAID
Jun 2018 – Apr 2022
A role for AAV Rep in genome packaging efficiency
Role: Principal Investigator
Funding: INTIMA BIOSCIENCE
Apr 2018 ACTIVE
Targeted Gene Therapy of Heart Failure Post Myocardial Infarction
Role: Principal Investigator
Funding: RICE UNIV via NATL INST OF HLTH NHLBI
Jan 2018 – Dec 2018
Characterization of Poliovirus VLPs Using a Mammalian Cell-Free System
Role: Co-Investigator
Funding: WORLD HLTH ORGANIZATION
Mar 2017 – Dec 2017
Characterization of Poliovirus VLPs Using a Mammalian Cell-Free System
Role: Co-Investigator
Funding: WORLD HLTH ORGANIZATION
Jan 2017 – May 2022
AAV1 Variants for CNS Targeted Therapies
Role: Principal Investigator
Funding: VOYAGER THERAPEUTICS INC
Sep 2016 ACTIVE
Collaborative Research: Geometric Elucidation of Supramolecular Assembly and Allostery, with Experimental Validation
Role: Co-Project Director/Principal Investigator
Funding: NATL SCIENCE FOU
Sep 2016 – Aug 2021
Developmental Pharmacology of Mitochondrial and Cytosolic GSTZ1
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Jan 2016 – Dec 2021
Studies on thymidylate synthase as a tumor-promoting oncogene for development of new allosteric inhibitors for cancer treatment
Role: Project Manager
Funding: NATL INST OF HLTH NCI
Sep 2014 – Aug 2019
The role of pH and protease activity in AAV viral transduction
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2013 – Mar 2019
Carbonic anhydrase and pH control in breast cancer cells
Role: Project Manager
Funding: NATL INST OF HLTH NCI

Contact Details

Phones:
Business:
(352) 294-8395
Emails:
Business:
rmckenna@ufl.edu
Addresses:
Business Mailing:
PO Box 100245
GAINESVILLE FL 32610
Business Street:
LG-179 UFBI
GAINESVILLE FL 32611