Robert McKenna,
Professor & Director Center for Structural Biology
Department:
MD-BIOCHEM / MOLECULAR BIOL
Business Phone:
(352) 294-8395
Business Email:
rmckenna@ufl.edu
About Robert McKenna
Professor Robert McKenna received his Ph.D. in crystallography at the University of London in 1989 under the direction of Professor Stephen Neidle for work on structural studies of nucleic-acid-targeted anti-cancer drug design. He then joined Professor Michael Rossmann’s laboratory at Purdue University, where he carried out research on structure to function correlation for ssDNA virus capsids. In 1995, he joined the Department of Biological Sciences at the University of Warwick, England, UK, as a research fellow, where he continued his research on structure-function analysis of virus capsids. Dr. McKenna joined the faculty at the University of Florida in 1999.
Teaching Profile
Courses Taught
2007-2025
BCH6744 Molecular Structure Determination by X-ray Crystallography
2017-2025
BCH6877 Recent Advances in Structural Biology
2015-2016,2018-2022,2020-2024,2022-2025
GMS6009 Principles of Drug Action and Therapeutics
2008,2011-2015,2015-2020,2017-2020
BCH6749C Numerical Methods in Structural Biology
2008-2024
BCH6746 Structural Biology: Macromolecular Structure Determination
2013-2019,2021-2025
BCH4024 Introduction to Biochemistry and Molecular Biology
2007-2008,2016-2021,2021
GMS5905 Special Topics in Biomedical Sciences
2015-2019
BCH6747 Structural Biology/Advanced Physical Biochemistry: Spectroscopy and Hydrodynamics
2014-2019,2021-2025
BCH6740 Physical Biochemistry/Structural Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
CHM7979 Advanced Research
2018
CHM7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2015-2017
GMS6895 CTS Journal Club
2013,2015-2017
BCH6971 Research for Master’s Thesis
2013-2017
BCH6910 Supervised Research
2013,2015-2017
BCH6905 Independent Studies in Biochemistry and Molecular Biology
2008-2016
BCH6875 Crystallography and Cryo-Electron Microscopy
2007-2011,2015-2021,2021
BCH4905 Biochemistry Senior Research
2011-2013
BCH6936 Biochemistry Seminar
2007-2010
BCH6107 Biophysical Techniques in Proteomics and Protein Science
2021-2025
BCH6744L Molecular Structure Determination by X-Ray Crystallography Laboratory
2021
GMS6003 Fundamentals of Graduate Research and Professional Development
2022-2025
GMS6001 Fundamentals of Biomedical Sciences I
Research Profile
My research interests are focused on interpreting how the structure of a biological molecule plays a role in its function. We use the techniques of X-ray and neutron crystallography and in-silico modeling to obtain 3D structural information and correlate this to mutational, kinetic, and biochemical data. The result is a structural map of the biological molecule in the context of its function . The goals of these studies are 1) to understand the mechanism of how the system works, and 2) to develop therapeutic strategies of treatments of human diseases attributed to these targeted biological molecules.
Current studies include: Carbonic anhydrases, manganese superoxide dismutase, HIV-protease, malaria-plasmepsins, the cancer-associated Mycoplasma hyorhinis protein Mh-p37.
Open Researcher and Contributor ID (ORCID)
0000-0002-2792-935X
Publications
Academic Articles
2025
Protein kinase D1 mitigation against etoposide induced DNA damage in prostate cancer is associated with increased α-Catenin.
The Prostate.
85(2):156-164
[DOI] 10.1002/pros.24812.
[PMID] 39428693.
2025
The Structural, Biophysical, and Antigenic Characterization of the Goose Parvovirus Capsid
Microorganisms.
13(1)
[DOI] 10.3390/microorganisms13010080.
2024
A comparative study of diaryl urea molecules with and without sulfonamide group on Carbonic anhydrase IX and XII inhibition and its consequence on breast cancer cells.
Bioorganic chemistry.
145
[DOI] 10.1016/j.bioorg.2024.107192.
[PMID] 38382393.
2024
Backbone NMR resonance assignments for the VP1u N-terminal receptor-binding domain of the human parvovirus pathogen B19.
Research square.
[DOI] 10.21203/rs.3.rs-4441481/v1.
[PMID] 38883784.
2024
Backbone NMR resonance assignments for the VP1u N-terminal receptor-binding domain of the human parvovirus pathogen B19.
Biomolecular NMR assignments.
18(2):147-152
[DOI] 10.1007/s12104-024-10181-7.
[PMID] 38904726.
2024
Disruption of the Physical Interaction Between Carbonic Anhydrase IX and the Monocarboxylate Transporter 4 Impacts Lactate Transport in Breast Cancer Cells.
International journal of molecular sciences.
25(22)
[DOI] 10.3390/ijms252211994.
[PMID] 39596062.
2024
Dissecting positive selection events and immunological drives during the evolution of adeno-associated virus lineages.
PLoS pathogens.
20(6)
[DOI] 10.1371/journal.ppat.1012260.
[PMID] 38885242.
2024
Feasibility of Domain Segmentation of B19V VP1u Using Intein Technology for Structural Studies.
Protein and peptide letters.
31(2):161-167
[DOI] 10.2174/0109298665277211231214065419.
[PMID] 38243925.
2024
Genome-Wide Transcriptional Roles of KSHV Viral Interferon Regulatory Factors in Oral Epithelial Cells.
Viruses.
16(6)
[DOI] 10.3390/v16060846.
[PMID] 38932139.
2024
Hyperacetylation mimetics within the tau filament core inhibits prion-like propagation of misfolded tau.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.04.12.589253.
[PMID] 38659970.
2024
Interspecies Expression of an EF-HAND CALCIUM-BINDING PROTEIN in Xanthomonas perforans Leads to Reduced Virulence and Decreased Immune Evasion in Tomato Plants.
Molecular plant-microbe interactions : MPMI.
37(11):784-800
[DOI] 10.1094/MPMI-07-24-0073-R.
[PMID] 39093823.
2024
Maize Streak Virus: Single and Gemini Capsid Architecture.
Viruses.
16(12)
[DOI] 10.3390/v16121861.
[PMID] 39772173.
2024
Mechanisms of AAV2 neutralization by human alpha-defensins.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.09.25.614754.
[PMID] 39386661.
2024
Overcoming resolution attenuation during tilted cryo-EM data collection.
Nature communications.
15(1)
[DOI] 10.1038/s41467-023-44555-7.
[PMID] 38195598.
2024
Structural characterization and epitope mapping of the AAVX affinity purification ligand.
Molecular therapy. Methods & clinical development.
32(4)
[DOI] 10.1016/j.omtm.2024.101377.
[PMID] 39677563.
2024
Structural characterization of antibody-responses from Zolgensma treatment provides the blueprint for the engineering of an AAV capsid suitable for redosing.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2024.05.01.590489.
[PMID] 38746165.
2024
Structural Characterization of Human Bufavirus 1: Receptor Binding and Endosomal pH-Induced Changes.
Viruses.
16(8)
[DOI] 10.3390/v16081258.
[PMID] 39205232.
2024
The Structure of Spiroplasma Virus 4: Exploring the Capsid Diversity of the Microviridae.
Viruses.
16(7)
[DOI] 10.3390/v16071103.
[PMID] 39066266.
2024
XFEL structure of carbonic anhydrase II: a comparative study of XFEL, NMR, X-ray and neutron structures.
Acta crystallographica. Section D, Structural biology.
80(Pt 3):194-202
[DOI] 10.1107/S2059798324000482.
[PMID] 38411550.
2023
A Single Surface-Exposed Amino Acid Determines Differential Neutralization of AAV1 and AAV6 by Human Alpha-Defensins.
Journal of virology.
97(3)
[DOI] 10.1128/jvi.00060-23.
[PMID] 36916912.
2023
Bipartite genome and structural organization of the parvovirus Acheta domesticus segmented densovirus.
Nature communications.
14(1)
[DOI] 10.1038/s41467-023-38875-x.
[PMID] 37316488.
2023
Development of new adeno-associated virus capsid variants for targeted gene delivery to human cardiomyocytes.
Molecular therapy. Methods & clinical development.
30:459-473
[DOI] 10.1016/j.omtm.2023.08.010.
[PMID] 37674904.
2023
First-in-class multifunctional TYMS nonclassical antifolate inhibitor with potent in vivo activity that prolongs survival.
JCI insight.
8(10)
[DOI] 10.1172/jci.insight.158798.
[PMID] 37097751.
2023
New Insights into Conformationally Restricted Carbonic Anhydrase Inhibitors.
Molecules (Basel, Switzerland).
28(2)
[DOI] 10.3390/molecules28020890.
[PMID] 36677947.
2023
Overcoming Resolution Attenuation During Tilted Cryo-EM Data Collection.
bioRxiv : the preprint server for biology.
[DOI] 10.1101/2023.07.14.548955.
[PMID] 37503021.
2023
Production and characterization of an AAV1-VP3-only capsid: An analytical benchmark standard.
Molecular therapy. Methods & clinical development.
29:460-472
[DOI] 10.1016/j.omtm.2023.05.002.
[PMID] 37273903.
2023
Protein Degradation by Gammaherpesvirus RTAs: More Than Just Viral Transactivators.
Viruses.
15(3)
[DOI] 10.3390/v15030730.
[PMID] 36992439.
2023
Structural and antigenic characterization of the avian adeno-associated virus capsid.
Journal of virology.
97(10)
[DOI] 10.1128/jvi.00780-23.
[PMID] 37702486.
2023
Structural and Biophysical Analysis of Adeno-Associated Virus Serotype 2 Capsid Assembly Variants.
Journal of virology.
97(7)
[DOI] 10.1128/jvi.01772-22.
[PMID] 37310260.
2023
Structural and functional characterization of capsid binding by anti-AAV9 monoclonal antibodies from infants after SMA gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy.
31(7):1979-1993
[DOI] 10.1016/j.ymthe.2023.03.032.
[PMID] 37012705.
2023
Structural Characterization of Canine Minute Virus, Rat and Porcine Bocavirus.
Viruses.
15(9)
[DOI] 10.3390/v15091799.
[PMID] 37766206.
2022
Capsid Structure of Aleutian Mink Disease Virus and Human Parvovirus 4: New Faces in the Parvovirus Family Portrait.
Viruses.
14(10)
[DOI] 10.3390/v14102219.
[PMID] 36298773.
2022
Cellular and molecular characterization of two novel asparagine synthetase gene mutations linked to asparagine synthetase deficiency.
The Journal of biological chemistry.
298(9)
[DOI] 10.1016/j.jbc.2022.102385.
[PMID] 35985424.
2022
Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity.
Journal of virology.
96(11)
[DOI] 10.1128/jvi.00335-22.
[PMID] 35532224.
2022
Ibuprofen: a weak inhibitor of carbonic anhydrase II.
Acta crystallographica. Section F, Structural biology communications.
78(Pt 11):395-402
[DOI] 10.1107/S2053230X22009761.
[PMID] 36322425.
2022
One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes.
Journal of medicinal chemistry.
65(1):824-837
[DOI] 10.1021/acs.jmedchem.1c01906.
[PMID] 34958217.
2022
Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders.
Science advances.
8(38)
[DOI] 10.1126/sciadv.abn4704.
[PMID] 36129972.
2022
Small Molecule Alkoxy Oriented Selectiveness on Human Carbonic Anhydrase II and IX Inhibition.
ChemMedChem.
17(11)
[DOI] 10.1002/cmdc.202200148.
[PMID] 35388618.
2022
Structural characterization of an envelope-associated adeno-associated virus type 2 capsid.
Virology.
565:22-28
[DOI] 10.1016/j.virol.2021.09.010.
[PMID] 34638006.
2022
Structural Dynamics and Activity of B19V VP1u during the pHs of Cell Entry and Endosomal Trafficking.
Viruses.
14(9)
[DOI] 10.3390/v14091922.
[PMID] 36146728.
2022
Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants.
Journal of virology.
96(3)
[DOI] 10.1128/JVI.01251-21.
[PMID] 34757842.
2022
Structures of LIG1 that engage with mutagenic mismatches inserted by polβ in base excision repair.
Nature communications.
13(1)
[DOI] 10.1038/s41467-022-31585-w.
[PMID] 35790757.
2022
The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII.
Journal of enzyme inhibition and medicinal chemistry.
37(1):930-939
[DOI] 10.1080/14756366.2022.2053526.
[PMID] 35306936.
2021
Adeno-associated Virus 9 Structural Rearrangements Induced by Endosomal Trafficking pH and Glycan Attachment.
Journal of virology.
95(19)
[DOI] 10.1128/JVI.00843-21.
[PMID] 34260280.
2021
Characterization of the GBoV1 Capsid and Its Antibody Interactions.
Viruses.
13(2)
[DOI] 10.3390/v13020330.
[PMID] 33672786.
2021
Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2.
Journal of structural biology.
213(4)
[DOI] 10.1016/j.jsb.2021.107795.
[PMID] 34509611.
2021
Completion of the AAV Structural Atlas: Serotype Capsid Structures Reveals Clade-Specific Features.
Viruses.
13(1)
[DOI] 10.3390/v13010101.
[PMID] 33450892.
2021
Erratum: Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase. Corrigendum.
IUCrJ.
8(Pt 2)
[DOI] 10.1107/S2052252521000208.
[PMID] 33708409.
2021
Handling drug-target selectivity: A study on ureido containing Carbonic Anhydrase inhibitors.
European journal of medicinal chemistry.
212
[DOI] 10.1016/j.ejmech.2020.113035.
[PMID] 33303238.
2021
Improved Genome Packaging Efficiency of Adeno-associated Virus Vectors Using Rep Hybrids.
Journal of virology.
95(19)
[DOI] 10.1128/JVI.00773-21.
[PMID] 34287038.
2021
Inhibition of Carbonic Anhydrase Using SLC-149: Support for a Noncatalytic Function of CAIX in Breast Cancer.
Journal of medicinal chemistry.
64(3):1713-1724
[DOI] 10.1021/acs.jmedchem.0c02077.
[PMID] 33523653.
2021
pH-Induced Conformational Changes of Human Bocavirus Capsids.
Journal of virology.
95(8)
[DOI] 10.1128/JVI.02329-20.
[PMID] 33472934.
2021
Receptor Switching in Newly Evolved Adeno-associated Viruses.
Journal of virology.
95(19)
[DOI] 10.1128/JVI.00587-21.
[PMID] 34232726.
2021
Structural Study of Aavrh.10 Receptor and Antibody Interactions.
Journal of virology.
95(23)
[DOI] 10.1128/JVI.01249-21.
[PMID] 34549984.
2020
“A Sweet Combination”: Developing Saccharin and Acesulfame K Structures for Selectively Targeting the Tumor-Associated Carbonic Anhydrases IX and XII.
Journal of medicinal chemistry.
63(1):321-333
[DOI] 10.1021/acs.jmedchem.9b01669.
[PMID] 31794211.
2020
Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking.
Viruses.
12(6)
[DOI] 10.3390/v12060668.
[PMID] 32575696.
2020
An arrestin-1 surface opposite of its interface with photoactivated rhodopsin engages with enolase-1.
The Journal of biological chemistry.
295(19):6498-6508
[DOI] 10.1074/jbc.RA120.013043.
[PMID] 32238431.
2020
Aspirin: A Suicide Inhibitor of Carbonic Anhydrase II.
Biomolecules.
10(4)
[DOI] 10.3390/biom10040527.
[PMID] 32244293.
2020
Biophysical Characterization of Cancer-Related Carbonic Anhydrase IX.
International journal of molecular sciences.
21(15)
[DOI] 10.3390/ijms21155277.
[PMID] 32722392.
2020
CAIX forms a transport metabolon with monocarboxylate transporters in human breast cancer cells.
Oncogene.
39(8):1710-1723
[DOI] 10.1038/s41388-019-1098-6.
[PMID] 31723238.
2020
Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies.
Molecular therapy. Methods & clinical development.
19:362-373
[DOI] 10.1016/j.omtm.2020.10.001.
[PMID] 33145372.
2020
Characterization of an intermolecular quaternary interaction between discrete segments of the Streptococcus mutans adhesin P1 by NMR spectroscopy.
The FEBS journal.
287(12):2597-2611
[DOI] 10.1111/febs.15158.
[PMID] 31782893.
2020
Comparative Analysis of the Capsid Structures of AAVrh.10, AAVrh.39, and AAV8.
Journal of virology.
94(6)
[DOI] 10.1128/JVI.01769-19.
[PMID] 31826994.
2020
Deep Analysis of Residue Constraints (DARC): identifying determinants of protein functional specificity.
Scientific reports.
10(1)
[DOI] 10.1038/s41598-019-55118-6.
[PMID] 32015389.
2020
Elucidating the role of metal ions in carbonic anhydrase catalysis.
Nature communications.
11(1)
[DOI] 10.1038/s41467-020-18425-5.
[PMID] 32917908.
2020
Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells.
European journal of medicinal chemistry.
190
[DOI] 10.1016/j.ejmech.2020.112112.
[PMID] 32044580.
2020
Molecular biology and structure of a novel penaeid shrimp densovirus elucidate convergent parvoviral host capsid evolution.
Proceedings of the National Academy of Sciences of the United States of America.
117(33):20211-20222
[DOI] 10.1073/pnas.2008191117.
[PMID] 32747554.
2020
Neutron crystallographic studies of carbonic anhydrase.
Methods in enzymology.
634:281-309
[DOI] 10.1016/bs.mie.2020.01.003.
[PMID] 32093837.
2020
Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone.
Journal of medicinal chemistry.
63(21):13064-13075
[DOI] 10.1021/acs.jmedchem.0c01390.
[PMID] 33085484.
2020
Structural characterization of a bat Adeno-associated virus capsid.
Journal of structural biology.
211(2)
[DOI] 10.1016/j.jsb.2020.107547.
[PMID] 32522552.
2020
Structural Characterization of Cuta- and Tusavirus: Insight into Protoparvoviruses Capsid Morphology.
Viruses.
12(6)
[DOI] 10.3390/v12060653.
[PMID] 32560452.
2020
Structural insights into the effect of active-site mutation on the catalytic mechanism of carbonic anhydrase.
IUCrJ.
7(Pt 6):985-994
[DOI] 10.1107/S2052252520011008.
[PMID] 33209313.
2020
Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase.
IUCrJ.
7(Pt 2):287-293
[DOI] 10.1107/S2052252520000986.
[PMID] 32148856.
2020
Sulfonamide Inhibitors of Human Carbonic Anhydrases Designed through a Three-Tails Approach: Improving Ligand/Isoform Matching and Selectivity of Action.
Journal of medicinal chemistry.
63(13):7422-7444
[DOI] 10.1021/acs.jmedchem.0c00733.
[PMID] 32519851.
2020
The splicing component ISY1 regulates APE1 in base excision repair.
DNA repair.
86
[DOI] 10.1016/j.dnarep.2019.102769.
[PMID] 31887540.
2019
3,17β-Bis-sulfamoyloxy-2-methoxyestra-1,3,5(10)-triene and Nonsteroidal Sulfamate Derivatives Inhibit Carbonic Anhydrase IX: Structure-Activity Optimization for Isoform Selectivity.
Journal of medicinal chemistry.
62(4):2202-2212
[DOI] 10.1021/acs.jmedchem.8b01990.
[PMID] 30721041.
2019
A non-catalytic function of carbonic anhydrase IX contributes to the glycolytic phenotype and pH regulation in human breast cancer cells.
The Biochemical journal.
476(10):1497-1513
[DOI] 10.1042/BCJ20190177.
[PMID] 31072911.
2019
Adeno-Associated Virus VP1u Exhibits Protease Activity.
Viruses.
11(5)
[DOI] 10.3390/v11050399.
[PMID] 31035643.
2019
Carbonic anhydrase II in complex with carboxylic acid-based inhibitors.
Acta crystallographica. Section F, Structural biology communications.
75(Pt 3):166-170
[DOI] 10.1107/S2053230X18018344.
[PMID] 30839290.
2019
High-Resolution Structural Characterization of a New Adeno-associated Virus Serotype 5 Antibody Epitope toward Engineering Antibody-Resistant Recombinant Gene Delivery Vectors.
Journal of virology.
93(1)
[DOI] 10.1128/JVI.01394-18.
[PMID] 30333169.
2019
Membrane-anchored carbonic anhydrase IV interacts with monocarboxylate transporters via their chaperones CD147 and GP70.
The Journal of biological chemistry.
294(2):593-607
[DOI] 10.1074/jbc.RA118.005536.
[PMID] 30446621.
2019
Next Generation Sequencing of the Pig αβ TCR Repertoire Identifies the Porcine Invariant NKT Cell Receptor.
Journal of immunology (Baltimore, Md. : 1950).
202(7):1981-1991
[DOI] 10.4049/jimmunol.1801171.
[PMID] 30777925.
2019
Pseudomonas aeruginosa β-carbonic anhydrase, psCA1, is required for calcium deposition and contributes to virulence.
Cell calcium.
84
[DOI] 10.1016/j.ceca.2019.102080.
[PMID] 31589941.
2019
Structural comparison of protiated, H/D-exchanged and deuterated human carbonic anhydrase IX.
Acta crystallographica. Section D, Structural biology.
75(Pt 10):895-903
[DOI] 10.1107/S2059798319010027.
[PMID] 31588921.
2019
Synthesis of saccharin-glycoconjugates targeting carbonic anhydrase using a one-pot cyclization/deprotection strategy.
Carbohydrate research.
476:65-70
[DOI] 10.1016/j.carres.2019.03.001.
[PMID] 30921738.
2019
Using neutron crystallography to elucidate the basis of selective inhibition of carbonic anhydrase by saccharin and a derivative.
Journal of structural biology.
205(2):147-154
[DOI] 10.1016/j.jsb.2018.12.009.
[PMID] 30639924.
2018
“Seriously Sweet”: Acesulfame K Exhibits Selective Inhibition Using Alternative Binding Modes in Carbonic Anhydrase Isoforms.
Journal of medicinal chemistry.
61(3):1176-1181
[DOI] 10.1021/acs.jmedchem.7b01470.
[PMID] 29266943.
2018
“To Be or Not to Be” Protonated: Atomic Details of Human Carbonic Anhydrase-Clinical Drug Complexes by Neutron Crystallography and Simulation.
Structure (London, England : 1993).
26(3):383-390.e3
[DOI] 10.1016/j.str.2018.01.006.
[PMID] 29429876.
2018
AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognition.
Virology.
518:369-376
[DOI] 10.1016/j.virol.2018.03.007.
[PMID] 29604478.
2018
Active-site solvent replenishment observed during human carbonic anhydrase II catalysis.
IUCrJ.
5(Pt 1):93-102
[DOI] 10.1107/S2052252517017626.
[PMID] 29354275.
2018
Assembly and disassembly intermediates of maize streak geminivirus.
Virology.
525:224-236
[DOI] 10.1016/j.virol.2018.09.011.
[PMID] 30300759.
2018
Atomic Resolution Structures of Human Bufaviruses Determined by Cryo-Electron Microscopy.
Viruses.
10(1)
[DOI] 10.3390/v10010022.
[PMID] 29300333.
2018
Atomic structure of a rationally engineered gene delivery vector, AAV2.5.
Journal of structural biology.
203(3):236-241
[DOI] 10.1016/j.jsb.2018.05.004.
[PMID] 29775653.
2018
Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors.
International journal of medicinal chemistry.
2018
[DOI] 10.1155/2018/2906519.
[PMID] 30112206.
2018
Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site.
Molecules (Basel, Switzerland).
23(5)
[DOI] 10.3390/molecules23051045.
[PMID] 29710858.
2018
Carbonic anhydrase II does not exhibit Nitrite reductase or Nitrous Anhydrase Activity.
Free radical biology & medicine.
117:1-5
[DOI] 10.1016/j.freeradbiomed.2018.01.015.
[PMID] 29355738.
2018
Carbonic anhydrase II microcrystals suitable for XFEL studies.
Acta crystallographica. Section F, Structural biology communications.
74(Pt 6):327-330
[DOI] 10.1107/S2053230X18006118.
[PMID] 29870015.
2018
Carbonic Anhydrases: Role in pH Control and Cancer.
Metabolites.
8(1)
[DOI] 10.3390/metabo8010019.
[PMID] 29495652.
2018
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Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations.
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In vitro evaluation of ESE-15-ol, an estradiol analogue with nanomolar antimitotic and carbonic anhydrase inhibitory activity.
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Mining the protein data bank to differentiate error from structural variation in clustered static structures: an examination of HIV protease.
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Preliminary X-ray crystallographic analysis of α-carbonic anhydrase from Thiomicrospira crunogena XCL-2.
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Production, purification, crystallization and structure determination of H-1 Parvovirus.
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Structural insight into the unique properties of adeno-associated virus serotype 9.
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The 3D Structure of Adeno-Associated Virus Serotype 9 and Its Unique Properties
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Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.
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Characterization of Carbonic Anhydrase Isozyme Specific Inhibition By Sulfamated 2-Ethylestra Compounds
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Chemical rescue of enzymes: proton transfer in mutants of human carbonic anhydrase II.
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Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.
Bioorganic & medicinal chemistry.
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Intramolecular proton shuttle supports not only catalytic but also noncatalytic function of carbonic anhydrase II.
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Kinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase II.
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Neutron structure of human carbonic anhydrase II: a hydrogen-bonded water network “switch” is observed between pH 7.8 and 10.0.
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Structural studies of adeno-associated virus serotype 8 capsid transitions associated with endosomal trafficking.
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Substrate-dependent interference of carbonic anhydrases with the glutamine transporter SNAT3-induced conductance.
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Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.
Bioorganic & medicinal chemistry.
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The Escherichia coli clamp loader can actively pry open the β-sliding clamp.
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Transport Activity of the Electrogenic Sodium-Bicarbonate Cotransporter Nbce1 Is Increased By a Functional Interaction With Carbonic Anhydrase Isoforms I, Ii, and III
Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire.
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Transport activity of the sodium bicarbonate cotransporter NBCe1 is enhanced by different isoforms of carbonic anhydrase.
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A short, strong hydrogen bond in the active site of human carbonic anhydrase II.
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Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.
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Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II.
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Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.
Bioorganic & medicinal chemistry.
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Emerging from pseudo-symmetry: the redetermination of human carbonic anhydrase II in monoclinic P2(1) with a doubled a axis.
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Enzymes for carbon sequestration: neutron crystallographic studies of carbonic anhydrase.
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Human bocavirus capsid structure: insights into the structural repertoire of the parvoviridae.
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Neutron structure of human carbonic anhydrase II: implications for proton transfer.
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Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency.
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Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II.
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Structural characterization of the dual glycan binding adeno-associated virus serotype 6.
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Structure of a monoclinic polymorph of human carbonic anhydrase II with a doubled a axis.
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Structure of the unbound form of HIV-1 subtype A protease: comparison with unbound forms of proteases from other HIV subtypes.
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Synchrotron Radiation Provides a Plausible Explanation for the Generation of a Free Radical Adduct of Thioxolone in Mutant Carbonic Anhydrase II.
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Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network.
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Cloning, expression, purification, crystallization and preliminary X-ray analysis of Mycoplasma genitalium protein MG289.
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Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank.
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Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties.
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Effect of active-site mutation at Asn67 on the proton transfer mechanism of human carbonic anhydrase II.
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Elucidation of the proton transport mechanism in human carbonic anhydrase II.
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High-resolution structure of human carbonic anhydrase II complexed with acetazolamide reveals insights into inhibitor drug design.
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Plasmepsin 9 as a New Target for Antimalarial Drug Discovery
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Preliminary joint neutron and X-ray crystallographic study of human carbonic anhydrase II.
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Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9.
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Recombinant plasmepsin 1 from the human malaria parasite plasmodium falciparum: enzymatic characterization, active site inhibitor design, and structural analysis.
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Structural insights into the extracytoplasmic thiamine-binding lipoprotein p37 of Mycoplasma hyorhinis.
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Structural Studies of Adeno-Associated Virus Serotypes Towards Improved Gene Therapy Applications
Molecular Therapy.
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Structural Studies of Autonomous Parvovirus Capsids and Their Glycan Interactions Towards Understanding Their Mechanisms of Cell Recognition and Pathogenicity
Glycobiology.
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Towards Characterizing Vector-Host Interactions: Adeno-Associated Virus Capsids in Complex With Antibody Fragments
Molecular Therapy.
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A Comparative Analysis of the Structural Architecture of Ssdna Viruses
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Assembly and structural analysis of a covalently closed nano-scale DNA cage.
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Design, synthesis, evaluation, and crystallographic-based structural studies of HIV-1 protease inhibitors with reduced response to the V82A mutation.
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Entrapment of carbon dioxide in the active site of carbonic anhydrase II.
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Genomic evolution in a virus under specific selection for host recognition.
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High-resolution structure of unbound human immunodeficiency virus 1 subtype C protease: implications of flap dynamics and drug resistance.
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Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37.
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The contribution of naturally occurring polymorphisms in altering the biochemical and structural characteristics of HIV-1 subtype C protease.
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Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism.
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Distinct expression and activity profiles of largemouth bass (Micropterus salmoides) estrogen receptors in response to estradiol and nonylphenol.
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Expression, purification and preliminary X-ray crystallographic studies of the human immunodeficiency virus 1 subtype C protease.
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Location of binding sites in small molecule rescue of human carbonic anhydrase II.
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Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 7.
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Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II.
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Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma: a single institution experience.
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Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.
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Structural and kinetic study of differences between human and Escherichia coli manganese superoxide dismutases.
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Structure of adeno-associated virus serotype 8, a gene therapy vector.
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Analysis of HIV-1 CRF_01 A/E protease inhibitor resistance: structural determinants for maintaining sensitivity and developing resistance to atazanavir.
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Crystal structure of nitrated human manganese superoxide dismutase: mechanism of inactivation.
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Expression, purification, kinetic, and structural characterization of an alpha-class carbonic anhydrase from Aedes aegypti (AaCA1).
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Flow cytometric features of angioimmunoblastic T-cell lymphoma.
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Host-selected amino acid changes at the sialic acid binding pocket of the parvovirus capsid modulate cell binding affinity and determine virulence.
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Identification of the sialic acid structures recognized by minute virus of mice and the role of binding affinity in virulence adaptation.
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Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.
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Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 1.
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Structurally mapping the diverse phenotype of adeno-associated virus serotype 4.
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Structure of human salivary alpha-amylase crystallized in a C-centered monoclinic space group.
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Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor.
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X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
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Active-site specificity of digestive aspartic peptidases from the four species of Plasmodium that infect humans using chromogenic combinatorial peptide libraries.
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Crystallization and preliminary X-ray analysis of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae.
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Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer.
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Production, purification, crystallization and preliminary X-ray analysis of adeno-associated virus serotype 8.
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Production, purification, crystallization and preliminary X-ray structural studies of adeno-associated virus serotype 5.
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Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.
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Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice.
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Structure of adeno-associated virus type 4.
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Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer.
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Characterization of incidentally identified minute clonal B-lymphocyte populations in peripheral blood and bone marrow.
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Comparing the accumulation of active- and nonactive-site mutations in the HIV-1 protease.
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Crystallization and preliminary X-ray crystallographic studies on recombinant rat choline acetyltransferase.
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Isolation and characterization of subgenomic DNAs encapsidated in “single” T = 1 isometric particles of Maize streak virus.
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Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase.
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Structural determination of a partially hemihedrally twinned actin crystal.
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Structural insights and functional implications of choline acetyltransferase.
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Molecular modeling of the rabbit colonic (HKalpha2a) H+, K+ ATPase.
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Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 4.
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Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer.
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2003
The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer.
Acta crystallographica. Section D, Biological crystallography.
59(Pt 1):93-104
[PMID] 12499545.
2002
Chemical rescue in catalysis by human carbonic anhydrases II and III.
Biochemistry.
41(9):3235-42
[PMID] 11863462.
2002
Crystallization and preliminary X-ray analysis of human carbonic anhydrase III.
Acta crystallographica. Section D, Biological crystallography.
58(Pt 5):849-52
[PMID] 11976500.
2002
Crystallization and preliminary X-ray analysis of the tumor metastasis factor p37.
Acta crystallographica. Section D, Biological crystallography.
58(Pt 12):2141-4
[PMID] 12454480.
2002
Crystallization and preliminary X-ray crystallographic studies on recombinant human carnitine acetyltransferase.
Acta crystallographica. Section D, Biological crystallography.
58(Pt 7):1193-4
[PMID] 12077440.
2002
Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase.
The Journal of biological chemistry.
277(41):38870-6
[PMID] 12171926.
2002
Microviridae, a family divided: isolation, characterization, and genome sequence of phiMH2K, a bacteriophage of the obligate intracellular parasitic bacterium Bdellovibrio bacteriovorus.
Journal of bacteriology.
184(4):1089-94
[PMID] 11807069.
2002
Polylysine induces an antiparallel actin dimer that nucleates filament assembly: crystal structure at 3.5-A resolution.
The Journal of biological chemistry.
277(23):20999-1006
[PMID] 11932258.
2001
Identification of aleutian mink disease parvovirus capsid sequences mediating antibody-dependent enhancement of infection, virus neutralization, and immune complex formation.
Journal of virology.
75(22):11116-27
[PMID] 11602751.
2001
Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II.
Biochemistry.
40(6):1741-8
[PMID] 11327835.
2001
Structure of the Maize streak virus geminate particle.
Virology.
279(2):471-7
[PMID] 11162803.
2000
A DNA-porphyrin minor-groove complex at atomic resolution: the structural consequences of porphyrin ruffling.
Proceedings of the National Academy of Sciences of the United States of America.
97(17):9476-81
[PMID] 10920199.
2000
Biochemical and physical characterization of parvovirus minute virus of mice virus-like particles.
Virology.
267(2):299-309
[PMID] 10662625.
2000
Unusual bone marrow manifestations of parvovirus B19 infection in immunocompromised patients.
Human pathology.
31(2):161-8
[PMID] 10685629.
1999
Three-dimensional structure of Aleutian mink disease parvovirus: implications for disease pathogenicity.
Journal of virology.
73(8):6882-91
[PMID] 10400786.
1998
Structural analysis of the Spiroplasma virus, SpV4: implications for evolutionary variation to obtain host diversity among the Microviridae.
Structure (London, England : 1993).
6(2):135-45
[PMID] 9519405.
1998
Structure determination of the phiX174 closed procapsid.
Acta crystallographica. Section D, Biological crystallography.
54(Pt 5):878-90
[PMID] 9757104.
1997
Structure of a viral procapsid with molecular scaffolding.
Nature.
389(6648):308-13
[PMID] 9305849.
1996
Atomic structure of the degraded procapsid particle of the bacteriophage G4: induced structural changes in the presence of calcium ions and functional implications.
Journal of molecular biology.
256(4):736-50
[PMID] 8642594.
1995
DNA packaging intermediates of bacteriophage φX174.
Structure (London, England : 1993).
3(4):353-363
[PMID] 7613866.
1994
Analysis of the single-stranded DNA bacteriophage phi X174, refined at a resolution of 3.0 A.
Journal of molecular biology.
237(5):517-43
[PMID] 8158636.
1994
Calcium ion-induced structural changes in bacteriophage phi X174.
Journal of molecular biology.
244(3):291-300
[PMID] 7966340.
1994
The structure of human parvovirus B19 at 8 A resolution.
Virology.
203(1):106-15
[PMID] 8030266.
1993
Structure determination of feline panleukopenia virus empty particles.
Proteins.
16(2):155-71
[PMID] 8392729.
1992
Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives.
Journal of medicinal chemistry.
35(8):1418-29
[PMID] 1573635.
1992
Atomic structure of single-stranded DNA bacteriophage phi X174 and its functional implications.
Nature.
355(6356):137-43
[PMID] 1370343.
1991
Assuring continued competence. Is recertification the way?
American journal of clinical pathology.
96(2):267-72
[PMID] 1677797.
1991
Preliminary X-ray crystallographic investigation of human parvovirus B19.
Virology.
184(1):170-4
[PMID] 1871964.
1990
Crystallographic and molecular modeling studies on 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione and its butyl analogue, inhibitors of mammalian aromatase. Comparison with natural substrates: prediction of enantioselectivity for N-alkyl derivatives.
Journal of medicinal chemistry.
33(9):2673-9
[PMID] 2391706.
1990
Preliminary investigation of the phage phi X174 crystal structure.
Journal of molecular biology.
212(2):345-50
[PMID] 2138678.
1988
Structures of the anticancer compounds N-(2-hydroxyethyl)-2-(3-nitro-1,2,4-triazol-1-yl)-acetamide (RB-6110) and 5-(1-aziridinyl)-3-nitro-1-(3-oxo-1-butyl)-1,2,4- triazole (RB-6162).
Acta crystallographica. Section B, Structural science.
44 ( Pt 6):672-6
[PMID] 3271560.
1976
Extended field radiotherapy in non-Hodgkin’s lymphoma.
Radiology.
118(2):457-9
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Grants
Sep 2024
ACTIVE
Engineering AAV for safe and efficient gene delivery to the human retina
Role: Co-Investigator
Funding: NATL INST OF HLTH NEI
May 2024
ACTIVE
AAV capsids and their cellular interactions
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2024
– Apr 2024
Structural characterization of AAV capsid ligand complexes
Role: Principal Investigator
Funding: AVITIDE
Jan 2024
– Jan 2024
Structural characterization of AAV capsid ligand complexes
Role: Principal Investigator
Funding: AVITIDE
Jan 2024
ACTIVE
A modified arrestin1 to enhance glycolysis in photoreceptors as a therapeutic approach to slowing retinal degeneration
Role: Co-Investigator
Funding: NATL INST OF HLTH NEI
Jan 2024
ACTIVE
Leaving no child behind: enabling universal access to AAV gene therapies by vector bio-engineering to evade pre-existing natural immunity
Role: Principal Investigator
Funding: CHILDRENS MEDICAL RESEARCH INSTITUTE
via NATL HEALTH AND MED RESEARCH COUNCIL
Nov 2022
– Oct 2023
A study into the expression of TTV and its possible development as a gene therapy vector
Role: Principal Investigator
Funding: INTIMA BIOSCIENCE
Feb 2022
– Jul 2022
Cryo-EM analysis of AAV capsid full/empty ratio determinations
Role: Principal Investigator
Funding: STRIDEBIO
Jan 2022
ACTIVE
RNA virus capture of host chemokines: Understanding novel viral mechanisms of immune manipulation
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Dec 2021
– Jan 2022
Generation of AAV1 VP3-only DNA empty capsids
Role: Principal Investigator
Funding: THERMO FINNIGAN
Aug 2021
– Oct 2021
Generation of AAV1 VP3 only DNA empty capsids
Role: Principal Investigator
Funding: THERMO FINNIGAN
Jun 2020
– May 2022
Adverum Task Order #2 – Structure determination of AAV variants and 3D homology model building
Role: Principal Investigator
Funding: ADVERUM BIOTECHNOLOGIES INC
Apr 2020
– Mar 2023
Correlative structure and function studies of adeno-associated virus particles during viral genome release
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAID
Mar 2020
– Feb 2023
Asparagine Synthetase Deficiency
Role: Co-Investigator
Funding: NATL INST OF HLTH NICHD
Dec 2019
– Apr 2024
AAV capsids and their cellular interactions
Role: Principal Investigator
Funding: NATL INST OF HLTH NIGMS
May 2019
ACTIVE
Anti-viral Mechanisms of Defensins
Role: Principal Investigator
Funding: UNIV OF WASHINGTON
via NATL INST OF HLTH NIAID
Jun 2018
– Apr 2022
A role for AAV Rep in genome packaging efficiency
Role: Principal Investigator
Funding: INTIMA BIOSCIENCE
Apr 2018
– Mar 2023
Targeted Gene Therapy of Heart Failure Post Myocardial Infarction
Role: Principal Investigator
Funding: RICE UNIV
via NATL INST OF HLTH NHLBI
Jan 2018
– Dec 2018
Characterization of Poliovirus VLPs Using a Mammalian Cell-Free System
Role: Co-Investigator
Funding: WORLD HLTH ORGANIZATION
Mar 2017
– Dec 2017
Characterization of Poliovirus VLPs Using a Mammalian Cell-Free System
Role: Co-Investigator
Funding: WORLD HLTH ORGANIZATION
Jan 2017
– May 2022
AAV1 Variants for CNS Targeted Therapies
Role: Principal Investigator
Funding: VOYAGER THERAPEUTICS INC
Sep 2016
– Aug 2023
Collaborative Research: Geometric Elucidation of Supramolecular Assembly and Allostery, with Experimental Validation
Role: Co-Project Director/Principal Investigator
Funding: NATL SCIENCE FOU
Sep 2016
– Aug 2021
Developmental Pharmacology of Mitochondrial and Cytosolic GSTZ1
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Jan 2016
– Dec 2021
Studies on thymidylate synthase as a tumor-promoting oncogene for development of new allosteric inhibitors for cancer treatment
Role: Project Manager
Funding: NATL INST OF HLTH NCI
Sep 2014
– Aug 2019
The role of pH and protease activity in AAV viral transduction
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2013
– Mar 2019
Carbonic anhydrase and pH control in breast cancer cells
Role: Project Manager
Funding: NATL INST OF HLTH NCI
Contact Details
Phones:
- Business:
- (352) 294-8395
Emails:
- Business:
- rmckenna@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100245
GAINESVILLE FL 32610 - Business Street:
-
LG-179 UFBI
GAINESVILLE FL 32611