Ramon C Sun

Ramon C Sun,

Associate Professor

Department: MD-BIOCHEM / MOLECULAR BIOL
Business Phone: (352) 294-8407
Business Email: ramonsun@ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-3009-1850

Publications

2022
In situ mass spectrometry imaging reveals heterogeneous glycogen stores in human normal and cancerous tissues
EMBO Molecular Medicine. 14(11) [DOI] 10.15252/emmm.202216029. [PMID] 36059248.
2022
Activation of Drp1 promotes fatty acids-induced metabolic reprograming to potentiate Wnt signaling in colon cancer
Cell Death & Differentiation. 29(10):1913-1927 [DOI] 10.1038/s41418-022-00974-5. [PMID] 35332310.
2022
ASK1 Regulates Bleomycin-induced Pulmonary Fibrosis.
American journal of respiratory cell and molecular biology. 66(5):484-496 [DOI] 10.1165/rcmb.2021-0465OC. [PMID] 35148253.
2022
High-dimensionality reduction clustering of complex carbohydrates to study lung cancer metabolic heterogeneity.
Advances in cancer research. 154:227-251 [DOI] 10.1016/bs.acr.2022.02.005. [PMID] 35459471.
2022
In situ spatial glycomic imaging of mouse and human Alzheimer’s disease brains
Alzheimer's & Dementia. 18(10):1721-1735 [DOI] 10.1002/alz.12523. [PMID] 34908231.
2022
Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Glycogen In Situ.
Methods in molecular biology (Clifton, N.J.). 2437:215-228 [DOI] 10.1007/978-1-0716-2030-4_15. [PMID] 34902151.
2022
Tissue-Specific Downregulation of Fatty Acid Synthase Suppresses Intestinal Adenoma Formation via Coordinated Reprograming of Transcriptome and Metabolism in the Mouse Model of Apc-Driven Colorectal Cancer
International Journal of Molecular Sciences. 23(12) [DOI] 10.3390/ijms23126510. [PMID] 35742953.
2021
In Situ Analysis of N-Linked Glycans as Potential Biomarkers of Clinical Course in Human Prostate Cancer
Molecular Cancer Research. 19(10):1727-1738 [DOI] 10.1158/1541-7786.mcr-20-0967.
2021
APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis.
Molecular neurodegeneration. 16(1) [DOI] 10.1186/s13024-021-00483-y. [PMID] 34488832.
2021
Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease
Brain. 144(8):2349-2360 [DOI] 10.1093/brain/awab110. [PMID] 33822008.
2021
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation.
Cell metabolism. 33(7):1404-1417.e9 [DOI] 10.1016/j.cmet.2021.05.003. [PMID] 34043942.
2021
Emerging roles of N-linked glycosylation in brain physiology and disorders
Trends in Endocrinology & Metabolism. 32(12):980-993 [DOI] 10.1016/j.tem.2021.09.006. [PMID] 34756776.
2021
Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools.
Aging. 13(6):7846-7871 [DOI] 10.18632/aging.202849. [PMID] 33744865.
2021
Evaluation of Glutaminase Expression in Prostate Adenocarcinoma and Correlation with Clinicopathologic Parameters
Cancers. 13(9) [DOI] 10.3390/cancers13092157. [PMID] 33947068.
2021
Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer’s disease
Cell Death & Disease. 12(11) [DOI] 10.1038/s41419-021-04237-y. [PMID] 34657143.
2021
Lactate supports a metabolic-epigenetic link in macrophage polarization
Science Advances. 7(46) [DOI] 10.1126/sciadv.abi8602. [PMID] 34767443.
2021
Purine synthesis as a target for radiation resistance in molecular glioblastoma.
Journal of the neurological sciences. 425 [DOI] 10.1016/j.jns.2021.117439. [PMID] 33887565.
2021
Regional N-glycan and lipid analysis from tissues using MALDI-mass spectrometry imaging
STAR Protocols. 2(1) [DOI] 10.1016/j.xpro.2021.100304. [PMID] 33554139.
2020
Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry
Carbohydrate Polymers. 230 [DOI] 10.1016/j.carbpol.2019.115651. [PMID] 31887930.
2020
APOE alters glucose flux through central carbon pathways in astrocytes.
Neurobiology of disease. 136 [DOI] 10.1016/j.nbd.2020.104742. [PMID] 31931141.
2020
Clear Cell Adenocarcinoma of the Urinary Bladder Is a Glycogen-Rich Tumor with Poorer Prognosis
Journal of Clinical Medicine. 9(1) [DOI] 10.3390/jcm9010138. [PMID] 31947882.
2020
Improved workflow for mass spectrometry–based metabolomics analysis of the heart
Journal of Biological Chemistry. 295(9):2676-2686 [DOI] 10.1074/jbc.ra119.011081.
2020
Loss of Rb1 Enhances Glycolytic Metabolism in Kras-Driven Lung Tumors In Vivo
Cancers. 12(1) [DOI] 10.3390/cancers12010237. [PMID] 31963621.
2020
Oral Gavage Delivery of Stable Isotope Tracer for In Vivo Metabolomics
Metabolites. 10(12) [DOI] 10.3390/metabo10120501. [PMID] 33302448.
2020
Spatial profiling of gangliosides in mouse brain by mass spectrometry imaging
Journal of Lipid Research. 61(12) [DOI] 10.1194/jlr.ilr120000870.
2020
The E3 ligase malin plays a pivotal role in promoting nuclear glycogenolysis and histone acetylation.
Annals of translational medicine. 8(5) [DOI] 10.21037/atm.2020.01.130. [PMID] 32309401.
2020
“Serine and One-Carbon Metabolism in Breast Cancer Metastasis”–Letter
Molecular Cancer Research. 18(11):1755-1755 [DOI] 10.1158/1541-7786.mcr-20-0646.
2019
Clinical Features, Survival and Prognostic Factors of Glycogen-Rich Clear Cell Carcinoma (GRCC) of the Breast in the U.S. Population
Journal of Clinical Medicine. 8(2) [DOI] 10.3390/jcm8020246. [PMID] 30769905.
2019
Nuclear Glycogenolysis Modulates Histone Acetylation in Human Non-Small Cell Lung Cancers.
Cell metabolism. 30(5):903-916.e7 [DOI] 10.1016/j.cmet.2019.08.014. [PMID] 31523006.
2019
Targeting Pathogenic Lafora Bodies in Lafora Disease Using an Antibody-Enzyme Fusion.
Cell metabolism. 30(4):689-705.e6 [DOI] 10.1016/j.cmet.2019.07.002. [PMID] 31353261.
2018
Correction: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS.
The Analyst. 143(4) [DOI] 10.1039/c8an90009d. [PMID] 29359211.
2018
Mitochondrial Metabolism in Major Neurological Diseases
Cells. 7(12) [DOI] 10.3390/cells7120229. [PMID] 30477120.
2017
Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing.
Nature communications. 8(1) [DOI] 10.1038/s41467-017-01518-z. [PMID] 29158483.
2017
Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS.
The Analyst. 143(1):311-322 [DOI] 10.1039/c7an01256j. [PMID] 29192912.
2016
Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours.
Scientific reports. 6 [DOI] 10.1038/srep31146. [PMID] 27498883.
2016
Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells.
Advances in experimental medicine and biology. 899:113-20 [DOI] 10.1007/978-3-319-26666-4_7. [PMID] 27325264.
2015
The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation.
Molecular cancer therapeutics. 14(8):1928-38 [DOI] 10.1158/1535-7163.MCT-14-0888. [PMID] 25995437.
2014
Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.
Cell metabolism. 19(2):285-92 [DOI] 10.1016/j.cmet.2013.11.022. [PMID] 24506869.
2011
Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells.
Molecular cancer. 10 [DOI] 10.1186/1476-4598-10-142. [PMID] 22093145.
2010
Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo.
Breast cancer research and treatment. 120(1):253-60 [DOI] 10.1007/s10549-009-0435-9. [PMID] 19543830.
. [DOI] 10.53354/pc.gr.153672.
APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
. [DOI] 10.1101/2022.05.17.492361.
APOE4 Lowers Energy Expenditure and Impairs Glucose Oxidation by Increasing Flux through Aerobic Glycolysis
. [DOI] 10.1101/2020.10.19.345991.
Compartmentalized glycogenolysis regulates lung cancer transcription
. [DOI] 10.1101/681833.
Rapid and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates using gas chromatography mass spectrometry
. [DOI] 10.1101/645556.

Contact Details

Phones:
Business:
(352) 294-8407
Emails:
Business:
ramonsun@ufl.edu
Addresses:
Business Mailing:
Biochemistry & Molecular Biology
PO Box 100245
Gainesville FL 32610
Business Street:
ARB R3-216A
1200 Newell Drive
GAINESVILLE FL 32610