ZHIPENG LI

ZHIPENG LI,

Assistant Professor

Department: MD-BIOCHEM / MOLECULAR BIOL
Business Phone: (352) 294-8382
Business Email: li.zhipeng@ufl.edu

About ZHIPENG LI

Dr. Li’s work focuses on lipid metabolism and cell death. And how cancer cells rewire their metabolic network to cope with various stress conditions and escape death. Recently, these two general interests have been merged into a newly defined cell death pathway called ferroptosis, an iron-dependent, regulated cell death caused by the excessive accumulation of lipid damage on membranes. His lab will continue investigating mechanisms underlying ferroptosis vulnerability in cancer cells and how selenium protects cells from oxidative stress.

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0001-8806-9667

Areas of Interest
  • Cancer metabolism
  • Ferroptosis
  • Lipid metabolism
  • Quality control
  • Selenium

Publications

2023
Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis.
Cell chemical biology. 30(9):1090-1103.e7 [DOI] 10.1016/j.chembiol.2023.04.007. [PMID] 37178691.
2023
Lipid Quality Control and Ferroptosis: From Concept to Mechanism.
Annual review of biochemistry. [DOI] 10.1146/annurev-biochem-052521-033527. [PMID] 37963395.
2023
Protocol for performing pooled CRISPR-Cas9 loss-of-function screens.
STAR protocols. 4(2) [DOI] 10.1016/j.xpro.2023.102201. [PMID] 37000620.
2022
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability.
Nature chemical biology. 18(7):751-761 [DOI] 10.1038/s41589-022-01033-3. [PMID] 35637349.
2020
Going through a phase.
Nature chemical biology. 16(2):111-112 [DOI] 10.1038/s41589-019-0448-6. [PMID] 31932722.
2020
Maturation of Lipophagic Organelles in Hepatocytes Is Dependent Upon a Rab10/Dynamin-2 Complex.
Hepatology (Baltimore, Md.). 72(2):486-502 [DOI] 10.1002/hep.31059. [PMID] 31808574.
2019
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.
Nature. 575(7784):688-692 [DOI] 10.1038/s41586-019-1705-2. [PMID] 31634900.
2016
A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets.
Science advances. 2(12) [DOI] 10.1126/sciadv.1601470. [PMID] 28028537.
2010
C. elegans screen identifies autophagy genes specific to multicellular organisms.
Cell. 141(6):1042-55 [DOI] 10.1016/j.cell.2010.04.034. [PMID] 20550938.
2009
SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans.
Cell. 136(2):308-21 [DOI] 10.1016/j.cell.2008.12.022. [PMID] 19167332.

Education

Ph.D.
2017 · Mayo Clinic
B.S.
2007 · China Agricultural University

Contact Details

Phones:
Business:
(352) 294-8382
Emails:
Business:
li.zhipeng@ufl.edu
Addresses:
Business Mailing:
Academic Research Building, R3-234
1200 Newell Drive
Gainesville FL 32610
Business Street:
Academic Research Building, R3-273
1200 Newell Drive
GAINESVILLE FL 32611