Jorg Bungert

Jorg Bungert,

PROFESSOR

Department: MD-BIOCHEM / MOLECULAR BIOL
Business Phone: (352) 273-8098
Business Email: jbungert@ufl.edu

Teaching Profile

Courses Taught
2007-2017,2019-2021
BCH7410 Advanced Gene Regulation
2020-2023
BCH6910 Supervised Research
2020-2023
BCH6971 Research for Master’s Thesis
2013-2014,2016-2023
GMS6001 Fundamentals of Biomedical Sciences I
2015-2023
MDU4010 Cell Biology Seminar
2020-2023
BCH6905 Independent Studies in Biochemistry and Molecular Biology
2020-2023
GMS5905 Special Topics in Biomedical Sciences
2019,2021-2022
BCH6415 Advanced Molecular and Cell Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2013,2015-2017,2017
GMS6061 Nuclear Structure and Dynamics
2014-2017
GMS6647 Transcriptional and Translational Control of Cell Growth and Proliferation
2006-2017
GMS6195 Epigenetics Journal Club
2013-2016
GMS6290 Genetics/Genomics Program Graduate Seminar
2007
MEL4003 Cell Biology Seminar
2022
BCH7412 Epigenetics of Human Disease and Development

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0003-1801-9706

Publications

2021
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response
Nucleic Acids Research. 49(10):5779-5797 [DOI] 10.1093/nar/gkab415. [PMID] 34048572.
2021
Super-enhancer mediated regulation of adult β-globin gene expression: the role of eRNA and Integrator
Nucleic Acids Research. 49(3):1383-1396 [DOI] 10.1093/nar/gkab002. [PMID] 33476375.
2020
LATS kinase-mediated CTCF phosphorylation and selective loss of genomic binding.
Science advances. 6(8) [DOI] 10.1126/sciadv.aaw4651. [PMID] 32128389.
2019
Phase Separation and Transcription Regulation: Are Super-Enhancers and Locus Control Regions Primary Sites of Transcription Complex Assembly?
BioEssays : news and reviews in molecular, cellular and developmental biology. 41(1) [DOI] 10.1002/bies.201800164. [PMID] 30500078.
2018
Computational design and experimental characterization of a novel β-common receptor inhibitory peptide.
Peptides. 104:1-6 [DOI] 10.1016/j.peptides.2018.04.001. [PMID] 29635062.
2018
Functional interrelationship between TFII‐I and E2F transcription factors at specific cell cycle gene loci
Journal of Cellular Biochemistry. 119(1):712-722 [DOI] 10.1002/jcb.26235. [PMID] 28657656.
2018
Identification of a Novel Enhancer/Chromatin Opening Element Associated with High-Level γ-Globin Gene Expression.
Molecular and cellular biology. 38(19) [DOI] 10.1128/MCB.00197-18. [PMID] 30012865.
2017
Engineered Zinc Finger DNA-Binding Domains: Synthesis, Assessment of DNA-Binding Affinity, and Direct Protein Delivery to Mammalian Cells.
Methods in molecular biology (Clifton, N.J.). 1654:361-375 [DOI] 10.1007/978-1-4939-7231-9_27. [PMID] 28986805.
2016
Distinct and Overlapping Dnmti Interactions With Multiple Transcription Factors in Erythroid Cells: Evidence for Co-Repressor Functions
Biochimica Et Biophysica Acta-Gene Regulatory Mechanisms. 1859(12):1515-1526 [DOI] 10.1016/j.bbagrm.2016.09.007.
2016
Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.
Nucleic acids research. 44(15):7173-88 [DOI] 10.1093/nar/gkw327. [PMID] 27141965.
2013
GATA-1 genome-wide occupancy associates with distinct epigenetic profiles in mouse fetal liver erythropoiesis.
Nucleic acids research. 41(9):4938-48 [DOI] 10.1093/nar/gkt167. [PMID] 23519611.
2012
Acetylation of histone deacetylase 1 regulates NuRD corepressor complex activity.
The Journal of biological chemistry. 287(48):40279-91 [DOI] 10.1074/jbc.M112.349704. [PMID] 23014989.
2012
Identification of Protein-Interacting Partners of Usf2 in Erythroid Cells
The FASEB's Journal. 26
2012
Neutralizing the function of a β-globin-associated cis-regulatory DNA element using an artificial zinc finger DNA-binding domain.
Proceedings of the National Academy of Sciences of the United States of America. 109(44):17948-53 [DOI] 10.1073/pnas.1207677109. [PMID] 23074246.
2011
Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.
Blood. 118(5):1386-94 [DOI] 10.1182/blood-2010-11-319111. [PMID] 21653943.
2011
Differential role of Nkx2-5 in activation of the atrial natriuretic factor gene in the developing versus failing heart.
Molecular and cellular biology. 31(22):4633-45 [DOI] 10.1128/MCB.05940-11. [PMID] 21930795.
2011
Gata4 and Sp1 regulate expression of the erythropoietin receptor in cardiomyocytes.
Journal of cellular and molecular medicine. 15(9):1963-72 [DOI] 10.1111/j.1582-4934.2010.01193.x. [PMID] 21029371.
2011
Role of helix-loop-helix proteins during differentiation of erythroid cells.
Molecular and cellular biology. 31(7):1332-43 [DOI] 10.1128/MCB.01186-10. [PMID] 21282467.
2010
Dot(1L) on the spot.
Blood. 116(22):4385-6 [DOI] 10.1182/blood-2010-09-305326. [PMID] 21109620.
2010
H4R3 methylation facilitates beta-globin transcription by regulating histone acetyltransferase binding and H3 acetylation.
Blood. 115(10):2028-37 [DOI] 10.1182/blood-2009-07-236059. [PMID] 20068219.
2010
Induction of nitric oxide by erythropoietin is mediated by the {beta} common receptor and requires interaction with VEGF receptor 2.
Blood. 115(4):896-905 [DOI] 10.1182/blood-2009-04-216432. [PMID] 19965681.
2010
Intrinsic and extrinsic effects of mafG deficiency on hematopoietic recovery following bone marrow transplant.
Experimental hematology. 38(12):1251-60 [DOI] 10.1016/j.exphem.2010.08.005. [PMID] 20813153.
2010
Regulation of Hdac1 Histone Deacetylase Activity During Hematopoesis
Blood. 116:1581-1582
2010
USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus.
The Journal of biological chemistry. 285(21):15894-905 [DOI] 10.1074/jbc.M109.098376. [PMID] 20236933.
2009
Calpeptin increases the activity of upstream stimulatory factor and induces high level globin gene expression in erythroid cells.
The Journal of biological chemistry. 284(30):20130-5 [DOI] 10.1074/jbc.M109.001461. [PMID] 19491096.
2009
Defective erythropoiesis in transgenic mice expressing dominant-negative upstream stimulatory factor.
Molecular and cellular biology. 29(21):5900-10 [DOI] 10.1128/MCB.00419-09. [PMID] 19704006.
2009
Gata4 Regulates Expression of the Erythropoietin Receptor in Cardiomyocytes.
Blood. 114
2009
Maneuver At the Transcription Start Site
Epigenetics. 4:1-4
2009
Nkx2-5-Dependent Transcriptional Regulation of Anf and Bnp Through a Common Distal Enhancer
Circulation. 120
2009
The Role of Hdac1 Acetylation in Hematopoiesis and Gata-1 Function.
Blood. 114
2009
Trans-regulation of histone deacetylase activities through acetylation.
The Journal of biological chemistry. 284(50):34901-10 [DOI] 10.1074/jbc.M109.038356. [PMID] 19822520.
2009
Transcriptional Regulation By Tal1 a Link Between Epigenetic Modifications and Erythropoiesis
Epigenetics. 4:257-261
2009
Transgenic mice expressing small interfering RNA against Gata4 point to a crucial role of Gata4 in the heart and gonads.
Journal of molecular endocrinology. 43(4):157-69 [DOI] 10.1677/JME-09-0030. [PMID] 19491195.
2008
Assembly and structural analysis of a covalently closed nano-scale DNA cage.
Nucleic acids research. 36(4):1113-9 [PMID] 18096620.
2008
Corepressor CtBP and nuclear speckle protein Pnn/DRS differentially modulate transcription and splicing of the E-cadherin gene.
Molecular and cellular biology. 28(5):1584-95 [PMID] 18086895.
2008
Locus control region mediated regulation of adult beta-globin gene expression.
Journal of cellular biochemistry. 105(1):9-16 [DOI] 10.1002/jcb.21820. [PMID] 18500726.
2008
Regulation of Chromatin Looping and Transcription By Prmt1 Mediated H4R3 Methylation
Blood. 112
2002
Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis.
British journal of haematology. 119(2):510-5 [PMID] 12406094.
1999
Hypersensitive site 2 specifies a unique function within the human beta-globin locus control region to stimulate globin gene transcription.
Molecular and cellular biology. 19(4):3062-72 [PMID] 10082573.

Grants

Mar 2020 – Aug 2022
Structure and Function of the human beta globin locus control region
Role: Principal Investigator
Funding: AMER SOC OF HEMATOLOGY
Jan 2019 – Feb 2020
Epigenetic regulation of hematopoiesis
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2018 – Jun 2020
Functional proteomic and genomic analysis of transcription factor TFII-I in erythroid cells
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jun 2018 – May 2020
The Role of Long Noncoding RNA in Hematopoiesis
Role: Principal Investigator
Funding: PENNSYLVANIA STATE UNIV via NATL INST OF HLTH NIDDK
Jun 2018 – May 2022
OR-DRPD-ROF2018: Development of in vivo targeted delivery and detection methods for potentially therapeutic synthetic DNA-binding proteins
Role: Principal Investigator
Funding: UF RESEARCH
Jul 2016 – May 2017
Activation of human gamma-globin gene expression using artificial zinc finger DNA-binding domains.
Role: Other
Funding: AMER HEART ASSOCIATION
Jan 2015 ACTIVE
UF Health Cancer Center Bridge Seed Grant funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL
Sep 2014 – Aug 2019
Structure and function of the human beta-globin locus control region
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2010 – Apr 2016
Functional Protemomics in differentiating erythroid cell
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK

Contact Details

Phones:
Business:
(352) 273-8098
Emails:
Business:
jbungert@ufl.edu
Addresses:
Business Mailing:
PO Box 100245
GAINESVILLE FL 32610
Business Street:
392A CANCER GENETICS RESEARCH COMPLEX
GAINESVILLE FL 326110001