Jianrong J Lu

Jianrong J Lu,

Associate Professor

Department: MD-BIOCHEM / MOLECULAR BIOL
Business Phone: (352) 273-8200
Business Email: jrlu@ufl.edu

Teaching Profile

Courses Taught
2013,2015-2020,2020-2022
BCH7412 Epigenetics of Human Disease and Development
2013-2023
BCH5413 Mammalian Molecular Biology and Genetics
2013-2014,2016-2021,2020-2023
BCH4905 Biochemistry Senior Research
2017-2023
GMS6001 Fundamentals of Biomedical Sciences I
2014-2017,2019-2023
GMS6647 Transcriptional and Translational Control of Cell Growth and Proliferation
2014,2017-2022
GMS6338 Recent Advances in Cancer Metastasis
2019-2022
BCH6415 Advanced Molecular and Cell Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2018
CHM7979 Advanced Research
2015
GMS6683 Fundamentals of Vascular Physiology and Pathology
2012
GMS5905 Special Topics in Biomedical Sciences
2009-2010
IDH4917 Undergrad Research

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-4969-6040

Publications

2021
Author response: Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation
. [DOI] 10.7554/elife.66095.sa2.
2021
Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation
eLife. 10 [DOI] 10.7554/elife.66095.
2021
Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma
Signal transduction and targeted therapy. 6(1) [DOI] 10.1038/s41392-020-00388-0. [PMID] 33473104.
2021
The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma
JCI Insight. 6(7) [DOI] 10.1172/jci.insight.139497. [PMID] 33830080.
2020
Enhancing nucleolytic resistance and bioactivity of functional nucleic acids by diverse nanostructures via in situ polymerization-induced self-assembly
Chembiochem. 22(4):754-759 [DOI] 10.1002/cbic.202000712. [PMID] 33051959.
2020
LATS kinase–mediated CTCF phosphorylation and selective loss of genomic binding
Science Advances. 6(8) [DOI] 10.1126/sciadv.aaw4651. [PMID] 32128389.
2019
Role of INSL4 Signaling in Sustaining the Growth and Viability of LKB1-Inactivated Lung Cancer.
Journal of the National Cancer Institute. 111(7):664-674 [DOI] 10.1093/jnci/djy166. [PMID] 30423141.
2019
The Warburg metabolism fuels tumor metastasis.
Cancer metastasis reviews. 38(1-2):157-164 [DOI] 10.1007/s10555-019-09794-5. [PMID] 30997670.
2018
CRTC1-MAML2 fusion-induced lncRNA LINC00473 expression maintains the growth and survival of human mucoepidermoid carcinoma cells
Oncogene. 37(14):1885-1895 [DOI] 10.1038/s41388-017-0104-0. [PMID] 29353885.
2018
Functional interrelationship between TFII-I and E2F transcription factors at specific cell cycle gene loci.
Journal of cellular biochemistry. 119(1):712-722 [DOI] 10.1002/jcb.26235. [PMID] 28657656.
2017
Epithelial-to-Pericyte Transition in Cancer
Cancers. 9(12) [DOI] 10.3390/cancers9070077. [PMID] 28677655.
2017
Relevance of epithelial-to-pericyte transition in cancer.
Molecular & cellular oncology. 4(1) [DOI] 10.1080/23723556.2016.1260672. [PMID] 28197535.
2016
cAMP/CREB-regulated LINC00473 marks LKB1-inactivated lung cancer and mediates tumor growth
Journal of Clinical Investigation. 126(6):2267-2279 [DOI] 10.1172/jci85250.
2016
Cancer cells remodel themselves and vasculature to overcome the endothelial barrier
Cancer Letters. 380(2):534-544 [DOI] 10.1016/j.canlet.2014.10.031. [PMID] 25449784.
2016
Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells.
The Journal of clinical investigation. 126(11):4174-4186 [DOI] 10.1172/JCI86623. [PMID] 27721239.
2016
Mof Acetylates the Histone Demethylase Lsd1 to Suppress Epithelial-To-Mesenchymal Transition
Cell Reports. 15(12):2665-2678 [DOI] 10.1016/j.celrep.2016.05.050.
2016
Src drives the Warburg effect and therapy resistance by inactivating pyruvate dehydrogenase through tyrosine-289 phosphorylation.
Oncotarget. 7(18):25113-24 [DOI] 10.18632/oncotarget.7159. [PMID] 26848621.
2015
FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development
Cancer Letters. 362(1):70-82 [DOI] 10.1016/j.canlet.2015.03.037. [PMID] 25827072.
2015
The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism.
Cancer letters. 356(2 Pt A):156-64 [DOI] 10.1016/j.canlet.2014.04.001. [PMID] 24732809.
2013
Proteomic and functional analyses reveal the role of chromatin reader SFMBT1 in regulating epigenetic silencing and the myogenic gene program.
The Journal of biological chemistry. 288(9):6238-47 [DOI] 10.1074/jbc.M112.429605. [PMID] 23349461.
2013
Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer’s disease.
EMBO molecular medicine. 5(1):52-63 [DOI] 10.1002/emmm.201201923. [PMID] 23184605.
2013
SNAI1-mediated epithelial-mesenchymal transition confers chemoresistance and cellular plasticity by regulating genes involved in cell death and stem cell maintenance.
PloS one. 8(6) [DOI] 10.1371/journal.pone.0066558. [PMID] 23799116.
2013
Stalling the engine of resistance: targeting cancer metabolism to overcome therapeutic resistance.
Cancer research. 73(9):2709-17 [DOI] 10.1158/0008-5472.CAN-12-3009. [PMID] 23610447.
2013
The malignant brain tumor (MBT) domain protein SFMBT1 is an integral histone reader subunit of the LSD1 demethylase complex for chromatin association and epithelial-to-mesenchymal transition.
The Journal of biological chemistry. 288(38):27680-27691 [DOI] 10.1074/jbc.M113.482349. [PMID] 23928305.
2012
Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion.
Oncogene. 31(4):469-79 [DOI] 10.1038/onc.2011.247. [PMID] 21706049.
2012
An in vivo model of epithelial to mesenchymal transition reveals a mitogenic switch.
Cancer letters. 326(2):183-90 [DOI] 10.1016/j.canlet.2012.08.013. [PMID] 22906417.
2012
Glucose oxidation modulates anoikis and tumor metastasis.
Molecular and cellular biology. 32(10):1893-907 [DOI] 10.1128/MCB.06248-11. [PMID] 22431524.
2012
Receptor tyrosine kinase ErbB2 translocates into mitochondria and regulates cellular metabolism.
Nature communications. 3 [DOI] 10.1038/ncomms2236. [PMID] 23232401.
2011
Response of estrogen receptor-positive breast cancer tumorspheres to antiestrogen treatments.
PloS one. 6(4) [DOI] 10.1371/journal.pone.0018810. [PMID] 21533195.
2011
Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation.
Proceedings of the National Academy of Sciences of the United States of America. 108(37):15231-6 [DOI] 10.1073/pnas.1104662108. [PMID] 21896759.
2010
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy.
The EMBO journal. 29(5):969-80 [DOI] 10.1038/emboj.2009.405. [PMID] 20075865.
2010
Microrna-125B Confers the Resistance of Breast Cancer Cells To Paclitaxel Through Suppression of Pro-Apoptotic Bcl-2 Antagonist Killer 1 (Bak1) Expression
Journal of Biological Chemistry. 285(28):21496-21507 [DOI] 10.1074/jbc.M109.083337. [PMID] 20460378.
2010
Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition
Oncogene. 29(35):4896-4904 [DOI] 10.1038/onc.2010.234. [PMID] 20562920.
2010
Warburg effect in chemosensitivity: targeting lactate dehydrogenase-A re-sensitizes taxol-resistant cancer cells to taxol.
Molecular cancer. 9 [DOI] 10.1186/1476-4598-9-33. [PMID] 20144215.
2008
Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors.
Proceedings of the National Academy of Sciences of the United States of America. 105(22):7821-6 [DOI] 10.1073/pnas.0711677105. [PMID] 18509053.
2007
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression
Proceedings of the National Academy of Sciences. 104(22):9381-9386 [DOI] 10.1073/pnas.0610279104. [PMID] 17517653.
2007
Histone Deacetylase 6 Regulates Growth Factor-Induced Actin Remodeling and Endocytosis
Molecular and Cellular Biology. 27(24):8637-8647 [DOI] 10.1128/mcb.00393-07.
2002
Control of Facial Muscle Development by MyoR and Capsulin
Science. 298(5602):2378-2381 [DOI] 10.1126/science.1078273.
2001
Association of COOH-terminal-binding Protein (CtBP) and MEF2-interacting Transcription Repressor (MITR) Contributes to Transcriptional Repression of the MEF2 Transcription Factor
Journal of Biological Chemistry. 276(1):35-39 [DOI] 10.1074/jbc.m007364200.
2000
Regulation of Skeletal Myogenesis by Association of the MEF2 Transcription Factor with Class II Histone Deacetylases
Molecular Cell. 6(2):233-244 [DOI] 10.1016/s1097-2765(00)00025-3.
2000
Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases
Proceedings of the National Academy of Sciences. 97(8):4070-4075 [DOI] 10.1073/pnas.080064097. [PMID] 10737771.
2000
Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation
Nature. 408(6808):106-111 [DOI] 10.1038/35040593. [PMID] 11081517.
2000
The basic helix-loop-helix transcription factor capsulin controls spleen organogenesis
Proceedings of the National Academy of Sciences. 97(17):9525-9530 [DOI] 10.1073/pnas.97.17.9525. [PMID] 10944221.
1999
FOG-2, a Heart- and Brain-Enriched Cofactor for GATA Transcription Factors
Molecular and Cellular Biology. 19(6):4495-4502 [DOI] 10.1128/mcb.19.6.4495. [PMID] 10330188.
1999
MyoR: A muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD
Proceedings of the National Academy of Sciences. 96(2):552-557 [DOI] 10.1073/pnas.96.2.552. [PMID] 9892671.
1998
A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy
Cell. 93(2):215-228 [DOI] 10.1016/s0092-8674(00)81573-1.
1998
Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs
Mechanisms of Development. 73(1):23-32 [DOI] 10.1016/s0925-4773(98)00030-6.
1998
Requirement of the MADS-box transcription factor MEF2C for vascular development.
Development (Cambridge, England). 125(22):4565-74 [PMID] 9778514.
1997
Specific Interaction of the PDZ Domain Protein PICK1 with the COOH Terminus of Protein Kinase C-α
Journal of Biological Chemistry. 272(51):32019-32024 [DOI] 10.1074/jbc.272.51.32019.
1997
The MEF2A 3′ untranslated region functions as a cis-acting translational repressor
Molecular and Cellular Biology. 17(5):2756-2763 [DOI] 10.1128/mcb.17.5.2756. [PMID] 9111346.
A New Folding Motif Formed with an Expanded Genetic Alphabet
. [DOI] 10.21203/rs.3.rs-1754248/v1.
FBXO11 deficiency in mice impairs lung development and aggravates cigarette smoke-induced airway fibrosis
. [DOI] 10.1101/2022.05.31.494154.

Grants

Aug 2020 ACTIVE
Signaling and Targeting of CRTC1-MAML2 Fusion Oncoprotein in Salivary Gland
Role: Faculty
Funding: NATL INST OF HLTH NIDCR
Jul 2020 – Dec 2021
Exploiting the metabolic weakness of EMT in breast cancer
Role: Principal Investigator
Funding: FL BREAST CANCER FOU
May 2020 ACTIVE
Molecular control of bone development and inflammation by FBXO11
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCR
Jul 2019 – Dec 2020
Exploring an EMT-specific vulnerability in breast cancer
Role: Principal Investigator
Funding: FL BREAST CANCER FOU
Feb 2019 ACTIVE
Aberrant CRTC activation as a unique vulnerability of lung cancer with LKB1 inactivation
Role: Faculty
Funding: NATL INST OF HLTH NCI
Jun 2016 – Feb 2019
Advanced cancers secrete GDF11 to induce cachexia
Role: Principal Investigator
Funding: UF DSR OPPORTUNITY FUND
Feb 2015 ACTIVE
UF Health Cancer Center Pilot Project Grants funded through the Florida Consortium of National Cancer Institute Centers Program
Role: Project Manager
Funding: UF HEALTH SHANDS HOSPITAL

Contact Details

Phones:
Business:
(352) 273-8200
Emails:
Business:
jrlu@ufl.edu
Addresses:
Business Mailing:
DEPT OF BIOCHEMISTRY AND MOLECULAR BIOLOGY
GAINESVILLE FL 326100001
Business Street:
2033 MOWRY RD
GAINESVILLE FL 32611