Antonette D Bennett,
AST SCTST
Department:
MD-BIOCHEM / MOLECULAR BIOL
Business Phone:
(352) 294-8394
Business Email:
dendena@ufl.edu
Teaching Profile
Courses Taught
2021-2024
BCH6936 Biochemistry Seminar
2021
GMS6001 Fundamentals of Biomedical Sciences I
2022
BCH4024 Introduction to Biochemistry and Molecular Biology
2024
BCH6740 Physical Biochemistry/Structural Biology
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0003-4986-7505
Publications
2022
Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders
Science Advances.
8(38)
[DOI] 10.1126/sciadv.abn4704.
[PMID] 36129972.
2021
Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2.
Journal of structural biology.
213(4)
[DOI] 10.1016/j.jsb.2021.107795.
[PMID] 34509611.
2021
Effects of Altering HSPG Binding and Capsid Hydrophilicity on Retinal Transduction by AAV.
Journal of virology.
95(10)
[DOI] 10.1128/JVI.02440-20.
[PMID] 33658343.
2020
Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking.
Viruses.
12(6)
[DOI] 10.3390/v12060668.
[PMID] 32575696.
2020
Attenuation of Heparan Sulfate Proteoglycan Binding Enhances In Vivo Transduction of Human Primary Hepatocytes with AAV2.
Molecular therapy. Methods & clinical development.
17:1139-1154
[DOI] 10.1016/j.omtm.2020.05.004.
[PMID] 32490035.
2020
Geminivirus structure and assembly.
Advances in virus research.
108:1-32
[DOI] 10.1016/bs.aivir.2020.09.005.
[PMID] 33837714.
2020
Restoring the natural tropism of AAV2 vectors for human liver
Science Translational Medicine.
12(560)
[DOI] 10.1126/scitranslmed.aba3312.
2020
Structure comparison of the chimeric AAV2.7m8 vector with parental AAV2.
Journal of structural biology.
209(2)
[DOI] 10.1016/j.jsb.2019.107433.
[PMID] 31859208.
2019
Adeno-Associated Virus VP1u Exhibits Protease Activity.
Viruses.
11(5)
[DOI] 10.3390/v11050399.
[PMID] 31035643.
2019
Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue.
Molecular therapy : the journal of the American Society of Gene Therapy.
27(3):611-622
[DOI] 10.1016/j.ymthe.2019.01.015.
[PMID] 30772143.
2018
A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.
Brain : a journal of neurology.
141(7):2014-2031
[DOI] 10.1093/brain/awy126.
[PMID] 29788236.
2018
AAV6 K531 serves a dual function in selective receptor and antibody ADK6 recognition.
Virology.
518:369-376
[DOI] 10.1016/j.virol.2018.03.007.
[PMID] 29604478.
2018
Assembly and disassembly intermediates of maize streak geminivirus.
Virology.
525:224-236
[DOI] 10.1016/j.virol.2018.09.011.
[PMID] 30300759.
2018
Atomic structure of a rationally engineered gene delivery vector, AAV2.5.
Journal of structural biology.
203(3):236-241
[DOI] 10.1016/j.jsb.2018.05.004.
[PMID] 29775653.
2017
Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS.
Molecular therapy. Nucleic acids.
8:184-197
[DOI] 10.1016/j.omtn.2017.06.011.
[PMID] 28918020.
2017
Thermal Stability as a Determinant of AAV Serotype Identity.
Molecular therapy. Methods & clinical development.
6:171-182
[DOI] 10.1016/j.omtm.2017.07.003.
[PMID] 28828392.
2016
Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.
Journal of virology.
90(19):8542-51
[DOI] 10.1128/JVI.00575-16.
[PMID] 27440903.
2016
Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors.
Journal of virology.
90(8):4215-4231
[DOI] 10.1128/JVI.00200-16.
[PMID] 26865709.
2016
Microbatch Mixing: “Shaken Not Stirred”, a Method for Macromolecular Microcrystal Production for Serial Crystallography
Crystal Growth & Design.
16(11):6214-6221
[DOI] 10.1021/acs.cgd.6b00643.
2016
Mutants at the 2-Fold Interface of Adeno-associated Virus Type 2 (AAV2) Structural Proteins Suggest a Role in Viral Transcription for AAV Capsids.
Journal of virology.
90(16):7196-7204
[DOI] 10.1128/JVI.00493-16.
[PMID] 27252527.
2014
Defining the stoichiometry and cargo load of viral and bacterial nanoparticles by Orbitrap mass spectrometry.
Journal of the American Chemical Society.
136(20):7295-9
[DOI] 10.1021/ja502616y.
[PMID] 24787140.
2014
OneBac: platform for scalable and high-titer production of adeno-associated virus serotype 1-12 vectors for gene therapy.
Human gene therapy.
25(3):212-22
[DOI] 10.1089/hum.2013.184.
[PMID] 24299301.
2013
Capsid antibodies to different adeno-associated virus serotypes bind common regions.
Journal of virology.
87(16):9111-24
[DOI] 10.1128/JVI.00622-13.
[PMID] 23760240.
2013
Comparative analysis of adeno-associated virus capsid stability and dynamics.
Journal of virology.
87(24):13150-60
[DOI] 10.1128/JVI.01415-13.
[PMID] 24067976.
2013
Construction, expression, and purification of recombinant αVβ5 integrin.
Protein expression and purification.
89(2):225-31
[DOI] 10.1016/j.pep.2013.04.002.
[PMID] 23583935.
2013
Molecular cloning, overexpression, and an efficient one-step purification of α5β1 integrin.
Protein expression and purification.
92(1):21-8
[DOI] 10.1016/j.pep.2013.08.013.
[PMID] 23993979.
2013
Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking.
Journal of virology.
87(9):4974-84
[DOI] 10.1128/JVI.02524-12.
[PMID] 23427155.
2012
Evidence for pH-dependent protease activity in the adeno-associated virus capsid.
Journal of virology.
86(21):11877-85
[DOI] 10.1128/JVI.01717-12.
[PMID] 22915820.
2012
Structural insight into the unique properties of adeno-associated virus serotype 9.
Journal of virology.
86(12):6947-58
[DOI] 10.1128/JVI.07232-11.
[PMID] 22496238.
2012
The 3D Structure of Adeno-Associated Virus Serotype 9 and Its Unique Properties
Molecular Therapy.
20
2011
Novel properties of tyrosine-mutant AAV2 vectors in the mouse retina.
Molecular therapy : the journal of the American Society of Gene Therapy.
19(2):293-301
[DOI] 10.1038/mt.2010.234.
[PMID] 21045809.
2009
Production, purification and preliminary X-ray crystallographic studies of adeno-associated virus serotype 9.
Acta crystallographica. Section F, Structural biology and crystallization communications.
65(Pt 7):715-8
[DOI] 10.1107/S1744309109021460.
[PMID] 19574648.
2009
Towards Characterizing Vector-Host Interactions: Adeno-Associated Virus Capsids in Complex With Antibody Fragments
Molecular Therapy.
17
2008
A Comparative Analysis of the Structural Architecture of Ssdna Viruses
Computational and Mathematical Methods in Medicine.
9(34):183-196
[DOI] 10.1080/17486700802168247.
Grants
Dec 2021
– Jan 2022
Generation of AAV1 VP3-only DNA empty capsids
Role: Co-Investigator
Funding: THERMO FINNIGAN
Aug 2021
– Oct 2021
Generation of AAV1 VP3 only DNA empty capsids
Role: Co-Investigator
Funding: THERMO FINNIGAN
Jun 2020
– May 2022
Adverum Task Order #2 – Structure determination of AAV variants and 3D homology model building
Role: Co-Investigator
Funding: ADVERUM BIOTECHNOLOGIES INC
Apr 2020
– Mar 2023
Correlative structure and function studies of adeno-associated virus particles during viral genome release
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAID
Contact Details
Phones:
- Business:
- (352) 294-8394
Emails:
- Business:
- dendena@ufl.edu
Addresses:
- Business Mailing:
-
1600 SW ARCHER RD
GAINESVILLE FL 32610 - Business Street:
-
BRAIN INSTITUTE RM#LG171
ANTONETTE BENNETT
GAINESVILLE FL 32603